b5242 Clinical pathophysiology

Faculty of Sports Studies
spring 2026

The course is not taught in spring 2026

Extent and Intensity
1/0/0. 4 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
prof. PharmDr. Petr Babula, Ph.D. (lecturer)
MUDr. Kateřina Kapounková, Ph.D. (lecturer)
prof. MUDr. Julie Vašků, Ph.D. (lecturer)
Guaranteed by
prof. MUDr. Julie Vašků, Ph.D.
Department of Physical Activities and Health Sciences – Faculty of Sports Studies
Supplier department: Department of Physical Activities and Health Sciences – Faculty of Sports Studies
Prerequisites
BOZP_OK(bozp_po_stud) && BOZP_OK(bozp_po_stud_fsps)
b5005
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to understand the basic etiopathogenetic conditions of the organism and selected diseases with a focus on civilizational weakening within the current concept of genetic predisposition and epigenetic dynamics. The graduate of the subject will also be able to think creatively about the possible consequences of the influence of movement activities on the human organism, especially in the field of biological effects on individual systems.
Learning outcomes
A graduate of the course will be able to:
- explain the issue of hypokinesia in relation to possible systemic changes in the organism and their consequences on health;
- list and describe the changes that occur in the organism from the point of view of pathophysiology as a result of an inappropriate lifestyle;
- to recommend basic exercise and biochemical tests in relation to possible weakening resulting from hypokinesia.
Syllabus
  • 1. Reaction of the cell to damage, oxidative stress (apoptosis, necrosis), Tumor transformation of the cell.
  • 2. Epigenetic regulation of gene expression.
  • 3. General manifestations of the disease (fever, pain, inflammation).
  • 4. Factors causing the disease.
  • 5. Acute and chronic stress, functional changes of the pituitary axis.
  • 6. Disorders of growth, development. Aging process, death.
  • 7. Pathophysiology of control systems.
  • 8. Acid-base balance disorders, water and electrolyte imbalance.
  • 9. Disorders of metabolism.
  • 10. Pathophysiology of blood circulation and blood system.
  • 11. Pathophysiology of the respiratory system and kidneys.
  • 12. Consequences of hypokinesia. Some systemic manifestations of insufficient physical activity.
  • 13. Metabolic syndrome (definition, signs, causes).
Literature
  • STEJSKAL, Pavel. Autonomní nervový systém, metabolický syndrom a pohybová aktivita (Autonomic nervous system, metabolic syndrome and physical activity.). 2014. info
  • DOVRTĚLOVÁ, Lenka; Iva HRNČIŘÍKOVÁ; Michal KUMSTÁT and Ivan STRUHÁR. Metabolický syndrom-mezioborový problém (Metabolic syndrome-interdisciplinary problem). 2014. info
  • KOHLÍKOVÁ, Eva. Patofyziologie ve schématech. 2., nezměn. vyd. Praha: Karolinum, 2012, 190 s. ISBN 9788024621715. info
  • MATĚJOVSKÁ KUBEŠOVÁ, Hana; Pavel WEBER; Hana MELUZÍNOVÁ; Vlasta POLCAROVÁ and Jana HRUBANOVÁ. Co je stárnutí z hlediska patofyziologie (Ageing from patophysiological point of view). Medical Tribune. 2010, VI, No 25, p. 5-25, 20 pp. ISSN 1214-8911. info
  • SVAČINOVÁ, Hana. Metabolický syndrom a pohybová aktivita (Metabolic syndrome and physical activity). Současná Klinická Praxe. Praha: Medica Heallthworld a.s., 2007, 6/2007, No 2, p. 52-54. ISSN 1213-7790. info
  • SVAČINA, Štěpán. Metabolický syndrom. 3. rozš. a přeprac. vyd. Praha: Triton, 2006, 282 s. ISBN 8072547828. info
  • KOHLÍKOVÁ, Eva. Cytopatologie, patobiochemie a patofyziologie : všeobecná část. 1. vyd. Praha: Karolinum, 2003, 259 s. ISBN 8024607174. info
Teaching methods
lecture, presentation, discussion;
-interactive syllabus;
-activities within flipped learning and blended learning methods.
Assessment methods
The entire course ends with an oral exam, graded on a scale of A–F
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught every week.
  • Permalink: https://is.muni.cz/course/fsps/spring2026/b5242