LF:aVLFA0721p Pharmacology I - lecture

aVLFA0721p Pharmacology I - lecture

Faculty of Medicine
autumn 2020

Extent and Intensity

2/0/0. 2 credit(s). Type of Completion: k (colloquium).

Teacher(s)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Timetable

Tue 6. 10. 14:00–15:40 B11/234, Tue 13. 10. 14:00–15:40 B22/116 aula, Tue 20. 10. 14:00–15:40 B22/116 aula, Tue 27. 10. 14:00–15:40 B22/116 aula, Tue 3. 11. 14:00–15:40 B22/116 aula, Tue 10. 11. 14:00–15:40 B22/116 aula, Tue 24. 11. 14:00–15:40 B22/116 aula, Tue 1. 12. 14:00–15:40 B11/234, Tue 8. 12. 14:00–15:40 B22/116 aula, Tue 15. 12. 14:00–15:40 B22/116 aula, Tue 5. 1. 14:00–15:40 B22/116 aula, Tue 12. 1. 14:00–15:40 B22/116 aula, Tue 19. 1. 14:00–15:40 B22/116 aula, Tue 26. 1. 14:00–15:40 B11/234

Prerequisites (in Czech)

aVLPF0622c Pathological Phys. II - prac. && aVLPA0622c Pathology II - practice

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (programme LF, M-GM)
General Medicine (eng.) (programme LF, M-VL)

Course objectives

The aims of the course are:
to explain the basic pharmacodynamic and pharmacokinetic processes and principles
to explain the basic principles of therapy of intoxications
to describe the factors that influence the drug effect

Learning outcomes

Student after the course:
knows basic pharmacodynamic principles
knowns basic pharmacokinetic principles
knows basic factors that influence the effect of drugs
is able to suggest therapeutic measures in case of drug intoxication

Syllabus

aVLFA0721p - Pharmacology I - Lectures

General medicine

Autumn semester 2020
1. PHARMACOLOGY AND ITS SUB-BRANCHES (6. 10. 2020)
Definition of pharmacology and its sub-branches of pharmacology. Drug, medical product – basic pharmacological terminology. Sources of research and development of new drugs. Principles of correct drug use – types of pharmacotherapy and rational pharmacotherapy.
2. OVERVIEW OF DRUG DOSAGE FORMS, ROUTES OF DRUG ADMINISTRATION (13. 10. 2020)
Classification and overview of drug dosage forms for ready-made production and individual preparation. Drug dosage forms with controlled release. Classification of routes of administration. Overview of innovative drug administration routes.
3. DRUG DEVELOPMENT LIFE CYCLE (20. 10. 2020)
Drug discovery. Preclinical and clinical drug testing. Marketing authorisation.
4. PHARMACOKINETICS I (27. 10. 2020)
General principles of drug's fate in the organism. Overview of the basic pharmacokinetic processes and parameters.
5. PHARMACOKINETICS II (3. 11. 2020)
Single, continual and repeated drug administration. Principles of therapeutic drug monitoring. Compartment models. Fundamentals of population pharmacokinetics.
6. PHARMACODYNAMICS (10. 11. 2020)
Mechanisms of drugs effects – classification, examples. Receptor theory – types of ligands and receptors. Change in drug effect after repeated administration.
7. FACTORS AFFECTING DRUG'S EFFECTS (17. 11. 2020 - NOTE: PUBLIC HOLIDAY, THE TOPIC WILL BE COVERED WITH THE PREVIOUS LECTURE))
Classification, overview and examples of factors affecting drug effects. Fundamentals of pharmacogenetics.
8. PHARMACOVIGILANCE AND DRUG'S SAFETY (24. 11. 2020)
Adverse effects of drugs - classification and characteristics. Pharmacovigilance in clinical research and practice. Therapeutic index, therapeutic range. Drug anamnesis, polypharmacy and introduction to drug interactions.
9. PHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM (1. 12. 2020)
Overview of pharmacology of sympathetic and parasympathetic nervous system – neurotransmission, receptors. Basic indications of substances affecting ANS.
10. BASIC PRINCIPLES OF BIOLOGICAL THERAPY, SPASMOLYTIC DRUGS (8. 12. 2020)
Definition of terms, advantages and disadvantages of biological treatment in comparison to conventional therapy. Fundamental principles of technologies used in production of biological medical products, their classification and examples of clinical use.
11. GENERAL AND LOCAL ANAESTHETIC AGENTS (15. 12. 2020)
Classification and pharmacological characteristics of general and local anaesthetic drugs.
12. ANALGESIC DRUGS (5. 1. 2021)
Classification of analgesic drugs. Basic pharmacological characteristics and examples of use of opioid analgesics, non-steroidal anti-inflammatory drugs and analgesic-antipyretic drugs.
13. PHARMACOTHERAPY OF DIABETES MELLITUS (12. 1. 2020)
Insulins and anti-diabetic drugs – classification and basic pharmacological characteristics.
14. PHARMACOLOGY OF SEX HORMONES (19. 1. 2020)
Analogues and antagonists FSH, LH. Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens basic pharmacological characteristics (classification, basic substances, therapeutic indications/contraindications, adverse effects).
15. GLUCOCORTICOIDS. IMMUNOPHARMACOLOGY - IMMUNOSUPRESSIVES AND IMMUNOMODULATORS, BIOLOGICS (26. 1. 2020)
Overview of glucocorticoids for both local and systemic administration, therapeutic use. Overview of drugs affecting immune system - classification, therapeutic use, basic pharmacological characteristics.

Literature

required literature

Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info

recommended literature

Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info

not specified

Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012, xii, 612. ISBN 9781451113143. info

Bookmarks

https://is.muni.cz/ln/tag/LF:aVLFA0721p!

Teaching methods

Lectures will provide theoretical background and will be available as online presentations provided as a synchronous lecture at the scheduled time (with the possibility of chat or teacher´s questions) or a will be provided ahead in the form of Power Point presentations with a subsequent discussion and consultation with the teacher at the time of the lecture according to the schedule.

Classes take place periodically in the afternoon. The lectures are followed by practical exercises. The lectures discuss the basic issues of the subject. This knowledge is further deepened via specific practical tasks in exercises. According to the syllabi, materials for self-study and preparation will be available in the study materials for each topic, including references to the relevant chapters in the textbook.

Assessment methods

Colloquium - ROPOT test - 40 multiple-choice questions with 3 - 5 answer options. The number of correct answers is given.

Student gets 2 points for each completely correct answer, i.e. maximum 80 points for the whole multiple-choice test. Time limit: 45 min. The MCQ test can be repeated only twice.

To pass the colloquium successfully the student has to obtain at least 40 points.

Language of instruction

English

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.

Listed among pre-requisites of other courses

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2021, autumn 2022, autumn 2023, autumn 2024.

Enrolment Statistics (autumn 2020, recent)
Permalink: https://is.muni.cz/course/med/autumn2020/aVLFA0721p

LF:aVLFA0721p Pharmacology I - lecture - Course Information

aVLFA0721p Pharmacology I - lecture

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