aF1FT3_13 Pharmaceutical Technology

Faculty of Pharmacy
Spring 2026

The course is not taught in Spring 2026

Extent and Intensity
3/2/4. 8 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. PharmDr. Aleš Franc, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
doc. PharmDr. Ruta Masteiková, CSc. (lecturer)
PharmDr. Miroslava Pavelková, Ph.D. (lecturer)
PharmDr. Jakub Vysloužil, Ph.D. (lecturer)
PharmDr. Kateřina Brückner, Ph.D. (seminar tutor)
doc. PharmDr. Aleš Franc, Ph.D. (seminar tutor)
doc. PharmDr. Jan Gajdziok, Ph.D. (seminar tutor)
PharmDr. Hana Hořavová (seminar tutor)
doc. PharmDr. Kateřina Kubová, Ph.D. (seminar tutor)
PharmDr. Miroslava Pavelková, Ph.D. (seminar tutor)
PharmDr. Jakub Vysloužil, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Guaranteed by
doc. PharmDr. Kateřina Kubová, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Prerequisites (in Czech)
aF1FT2_13 Pharmceutical Technology II
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.
Learning outcomes
Upon completion of the course, the student will:
-describe the classification, requirements, excipients, and technological procedures for the preparation and production of solid dosage forms including their evaluation;
-theoretically describe the classification, requirements, excipients, and technological procedures of preparation/production, and evaluation of controlled release dosage forms including their evaluation;
- identify the basic aspects of solid dosage forms relating to drug bioavailability;
- prepare practically semi-solid and solid dosage forms under pharmacy conditions;
- identifies basic incompatibilities in the preparation of liquid and semi-solid dosage forms;
- explain the basic principles of GMP
Key topics
SYLLABUS OF LECTURES
1. Rectal dosage forms - definition, classification, properties. Suppositories, excipients, preparation, quality evaluation.
2. Vaginal dosage forms - definition, classification, properties, excipients, quality evaluation.
3. Granules, basic granulation techniques and equipment. Quality evaluation of powders and granules.
4. Powders, classification, particle size and effect on drug bioavailability; preparation, use and quality evaluation. 5. Incompatibilities in semisolid and solid dosage forms.
6. Tablets - classification, basic compression techniques. Excipients for tablets. Quality evaluation and use.
7. Coated products - classification, basic coating techniques, quality evaluation and use.
8. Pharmaceutical packaging.
9. Drug microforms. Definition, classification, characteristics, production technology, quality assessment
10. Transdermal preparations. Basic types of transdermal therapeutic systems. Excipients for transdermal preparations. Quality evaluation and use.
11. Aerodispersions - definition, classification, properties. Basic types of inhalation systems. Excipients for aerodispersions. Quality evaluation and use.
12. Capsules - classification, production, excipients, quality evaluation and use.
13. Controlled-release oral dosage forms
14.The principles of good manufacturing practice.

SEMINARS AND PRACTICAL TRAINING
1. Ointments. Preparation and evaluation.
2. Creams. Preparation and evaluation.
3. Pastes and gels. Preparation and evaluation.
4. Rectal suppositories. Determination of calibration coefficient, preparation of suppositories with known base replacement coefficient.
5. Rectal suppositories. Preparation of suppositories with unknown base replacement coefficient. Preparation of vaginal globules.
6. Non-divided and divided powders. Preparation and evaluation. Suppositories ans vaginal globules - test.
7. Technological procedures in preparation of complicated prescriptions of semisolid dosage forms, powders and suppositories.
8. Solving of incompatibilities in prescriptions on semisolid and solid dosage forms, powders and suppositories, preparations according to prescriptions.
9. Alternative training.
10. Production of tablets by direct compression/Granulation techniques.
11. Granulation techniques/Production of tablets by direct compression.
12. Fluid bed granulation technique/Evaluation of solid dosage forms.
13. Evaluation of solid dosage forms/Fluid bed granulation technique.
14. Test. Prastical skills testing.
Study resources and literature
    required literature
  • Český lékopis - platné vydání a doplňky
  • Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7. info
    recommended literature
  • Evropský lékopis - platné vydání a doplňky
  • Advances and challenges in pharmaceutical technology : materials, process development and drug delivery strategies. Edited by Amit Kumar Nayak - Kunal Pal - Indranil Banerjee - Samarendra Maji - U. London: Academic Press, 2021, 1 online. ISBN 9780128203002. URL info
  • Aqueous polymeric coatings for pharmaceutical dosage forms. Edited by Linda A. Felton. Fourth edition. Boca Raton, FL: CRC Press, 2017, 1 online. ISBN 9781315369938. URL info
  • Drug delivery : principles and applications. Edited by Binghe Wang - Longqin Hu - Teruna Siahaan. Second edition. Hoboken, New Jersey: Wiley, 2016, 1 online. ISBN 9781118833230. URL info
  • RABIŠKOVÁ, Miloslava. Moderní lékové formy pro orální a peroální aplikaci. Bratislava: Univerzita Komenského, 2009, 175 s. ISBN 9788022327596. info
Approaches, practices, and methods used in teaching
1.Lectures.
2.Lab training
3.Homework
Method of verifying learning outcomes and course completion requirements
Continusous written tests, oral examination
Language of instruction
Czech
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