F1FK1_14 Pharmacokinetics

Faculty of Pharmacy
Spring 2020
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Peter Kollár, Ph.D. (lecturer)
PharmDr. Bc. Hana Kotolová, Ph.D. (lecturer)
doc. PharmDr. Peter Kollár, Ph.D. (seminar tutor)
PharmDr. Bc. Hana Kotolová, Ph.D. (seminar tutor)
Guaranteed by
doc. PharmDr. Peter Kollár, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Aims: Pharmacokinetics course deals with the fundamental principles of absorption, distribution, metabolism, and the elimination of drugs by the human body in time as well as clinical application, including case studies of commonly dosed drugs. Basic aim of education in Pharmacokinetics for students of pharmacy is getting deep knowledge in processes, which take place in relation to time course of drug after administration.
Understanding of pharmacokinetics patterns is important for insight into rational drug dosage in clinical practise. Application of the pharmacokinetic theory to clinical problems involved in optimizing and monitoring drug use in patients is important part of pharmacists work.
Syllabus
  • Introduction to pharmacokinetics (Pharmacokinetic processes,
    Basic pharmacokinetic principles)
    Description of the pharmacokinetic processes (absorption, distribution, metabolism, and the elimination of drugs)
    Pharmacokinetic parameters (description of pharmacokinetic parameters and their clinical importance)
    Factors of non-genetic origin affecting the drug kinetics
    Factors of genetic origin affecting the drug kinetics
    Toxicokinetics
    TDM -Therapeutic Drug Monitoring I. (Description and general principles)
    TDM -Therapeutic Drug Monitoring II. (Methodic and
    procedures of TDM in clinical practice)
    Bioequivalence. Pharmacokinetics in the clinical trials
    Pharmacokinetic interactions - description

    Pharmacokinetic interactions - casuistics solution
    Special kinetics: Cytostatics
    Special kinetics: Antibiotics
    FINAL TEST
Literature
    required literature
  • Dostálek M a kolektiv. Farmakokinetika. Grada Publishing, 2006. info
  • Kollár Peter. Farmakokinetika pro farmaceuty. URL info
  • Švihovec Jan a kolektiv. Farmakologie. Grada, Praha, 2018. ISBN 978-80-247-5558-8. URL info
  • Martínková Jiřina a kolektiv. Farmakologie pro studenty zdravotnických oborů. Grada, Praha, 2018. ISBN 978-80-247-4157-4. URL info
  • Lüllmann H., Mohr K., Hein L. Barevný atlas farmakologie. Grada, Praha, 2012. ISBN 978-80-247-3908-3. URL info
    recommended literature
  • Whalen K. Lippincott Illustrated Reviews: Pharmacology, 7th edition. Lippincott Williams & Wilkins, USA, 2018. ISBN 978-1496384133. info
  • Humphrey P. Rang, Maureen M. Dale, James M. Ritter and Rod J. Fl. Rang & Dale's Pharmacology, 8th Edition. 2016. ISBN 978-0702053627. info
  • Trevor A, Katzung B, Masters S., Knuidering-Hall M. Katzung & Trevor's Pharmacology Examination and Board Review. McGraw-Hill Medical, 2012. ISBN 0071789235. info
  • Katzung BG. Basic and Clinical Pharmacology. McGraw-Hill Medical, 2011. ISBN 978-0071764018. info
  • Lincová Dagmar, Farghali, Hassan a kol. Základní a aplikovaná farmakologie. Galén, Praha, 2007. ISBN 9788072623730. info
  • Květina J. a kol. Farmakologie pro farmaceuty 2. díl. VFU Brno, 2003. info
  • Květina J. aa kol. Farmakologie pro farmaceuty 3. díl. VFU Brno, 2000. info
  • Květina J. a kol. Farmakologie pro farmaceuty 1. díl. VFU Brno, 1999. info
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
  • Enrolment Statistics (recent)
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