F1FG2_12 Pharmacognosy II

Faculty of Pharmacy
Spring 2023
Extent and Intensity
2/5/0. 10 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Renata Kubínová, Ph.D. (lecturer)
prof. RNDr. Václav Suchý, DrSc., dr. h.c. (lecturer)
prof. PharmDr. Karel Šmejkal, Ph.D. (lecturer)
PharmDr. Ivana Daňková, Ph.D. (seminar tutor)
PharmDr. Margita Dvorská, Ph.D. (seminar tutor)
PharmDr. Mária Gáborová, Ph.D. (seminar tutor)
PharmDr. Dagmar Jankovská, Ph.D. (seminar tutor)
doc. PharmDr. Renata Kubínová, Ph.D. (seminar tutor)
PharmDr. Alice Sychrová, Ph.D. (seminar tutor)
prof. PharmDr. Karel Šmejkal, Ph.D. (seminar tutor)
Mgr. Ing. Jiří Václavík, Ph.D. (seminar tutor)
Mgr. Petra Herczogová (seminar tutor)
PharmDr. Sabína Jusková, Ph.D. (seminar tutor)
PharmDr. Milan Malaník, Ph.D. (seminar tutor)
PharmDr. Lenka Molčanová, Ph.D. (seminar tutor)
Mgr. Polina Shpet (assistant)
Guaranteed by
prof. PharmDr. Karel Šmejkal, Ph.D.
Department of Natural Drugs – Departments – Faculty of Pharmacy
Contact Person: Mgr. Polina Shpet
Supplier department: Department of Natural Drugs – Departments – Faculty of Pharmacy
Timetable
Wed 8:30–10:10 44-056
  • Timetable of Seminar Groups:
F1FG2_12/01: Mon 7:15–11:25 45-229, I. Daňková
F1FG2_12/02: Mon 11:30–15:40 45-229, P. Herczogová, D. Jankovská
F1FG2_12/03: Mon 15:45–19:55 45-229, S. Jusková, R. Kubínová, J. Václavík
F1FG2_12/04: Tue 7:30–11:40 45-229, P. Shpet, K. Šmejkal
F1FG2_12/05: Tue 12:00–16:10 45-229, M. Gáborová, L. Molčanová
Prerequisites
F1FG1_12 Pharmacognosy I
The students should have passed basic subject touching organic chemistry, analytical chemistry, biology, botany, and physiology.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 165 student(s).
Current registration and enrolment status: enrolled: 103/165, only registered: 0/165, only registered with preference (fields directly associated with the programme): 0/165
fields of study / plans the course is directly associated with
Course objectives
Objectives of Pharmacognosy are to impart knowledges of those drugs of biological origin and their constituents that are of value for their therapeutic, profylactic and diagnostic use in the human and veterinary medicine.
Its scope includes the study of the physical, chemical, biochemical and biological properties of drugs, drug substances, or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources. Research problems in pharmacognosy include studies in the areas of phytochemistry, microbial chemistry, biosynthesis, biotransformation, chemotaxonomy, and other biological and chemical sciences.
Pharmacognosy represents a highly interdisciplinary science which is one of five major areas of pharmaceutical education.

Learning outcomes
The student must be able to microscopically and macroscopically identify selected drugs, know their main content substances, use, basic biosynthetic reactions, basal classes of secondary metabolites. Know the main plants used in the pharmacy. Chemical characteristics of secondary metabolites, basic knowledge of structure-activity relationships, basic knowledge of adverse effects and interactions.
Syllabus
  • Syllabus of lectures
    " Drugs affecting the central and peripheral nervous system
    " Drugs affecting vegetative nervous system
    " Drugs affecting the cardiovascular system
    " Drugs affecting hemocoagulation, fibrinolysis and used as the substitution of blood plasma
    " Drugs affecting water balance of the organism
    " Drugs affecting the respiratory system
    " Drugs affecting the digestive system
    " Uterotonics, antiuratics, antiphlogistics
    " Dietetics, roborants, geriatrics, sources of vitamins, supporting therapy of diabetes mellitus
    " Hormones, enzymes
    " Anti-infectious and anti-invasive drugs
    " Drugs used for their local anesthetic activity
    " Biogenic additives
    " Natural substances inspirational for synthesis
    SYLABUS OF PRACTICAL CLASSES FROM PHARMACOGNOSY II
    1. Drugs containing carbohydrates
    Identification assays
    Purity assays
    2. Drugs containing polysaccharides and mucilages
    Identification assays
    Determination of number of swelling
    3. Drugs containing phenolics glycosides
    Identification assays
    Chromatographic proof of hydroquinones and arbutin
    Determination of arbutin content by titration
    4. Drugs containing cardioglycosides (test no. 1)
    Identification assays
    Chromatographic proof
    Colorimetric determination
    5. Drugs containing the anthracene derivatives
    Identification assays
    Chromatographic proof of anthraquinone derivatives
    Quantification of hypericin
    6. Drugs containing flavonoid glycosides
    Identification assays
    Colorimetric quantification of flavonoids
    Chromatographic proof
    7. Drugs containing saponins (test no. 2)
    Identification assays
    Determination of hemolytic activity using blood agar
    Determination of foaming power according to Kofler
    Quantification of glycyrrhizinic acid
    8. Drugs containing tannins
    Identification assays color, precipitation
    Chromatographic proof
    Quantification of tannins in drug quantification of total phenolics
    9. Drugs containing essential oils
    Identification assays
    Chromatographic proof
    Quantification of essential oils
    10. Drugs containing alkaloids I. (test no. 3)
    Precipitation and color reaction of alkaloids
    Quantification of tropane alkaloids using titration
    11. Drugs containing alkaloids II.
    Precipitation and color reaction of alkaloids
    Gravimetric quantification of purine alkaloids
    Thin layer chromatography of opium alkaloids
    12. Drugs containing bitter substances
    Identification assays
    Determination of number of bitterness
    13. Drugs containing thioglycosides of Brassicaceae
    Identification assays and purity
    14. Drugs containing coumarins, anthocyanins ( test no. 4)
    Chromatographic proof
Literature
    required literature
  • Šmejkal, K., Kubínová, R., Suchý, V. Farmakognozie část obecná. 2016. ISBN 978-80-7305-785-5. info
  • Kubínová R., Jankovská D. Obrazový atlas farmaceuticky významných drog. Brno, 2013. ISBN 978-80-7305-667-4. info
  • Suchý V. a kol. Praktická cvičení z farmakognosie. Brno, 2013. ISBN 978-80-7305-659-9. info
  • Tomko, J. a kol. Farmakognózia. Osveta, 1999. info
  • Suchý, V. Farmakognosie, část všeobecná, část speciální I. UK Bratislava, 1994. info
    recommended literature
  • Český lékopis 2017. 2017. ISBN 859-404-924-045-6. info
  • Nagy, M., Mučaji, P., Grančai, D. Farmakognózia. 2017. ISBN 9788089631643. info
  • Samuelsson G., Bohlin L. Drugs of Natural Origin. A Treatise of Pharmacognosy. 7th revised edition. 2015. info
  • Grančai, D., Nagy, M., Mučaji, P. Farmakognózia - Biogenéza prírodných látok. 2015. ISBN 978-80-8063-368-4. info
  • Suchý V. Fytofarmaka. In Kuchař M. ed. Farmaceutický encyklopedický slovník. Praha, 2014. info
  • Wichtl M. Herbal Drugs and Phytopharmaceuticals. 2002. info
  • Dewick P.M. Medicinal Natural Products. 2002. info
  • Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 1999. info
  • Bučková, A. a kol. Praktické cvičenia z farmakognózie, chemická časť. UK Bratislava, 1993. info
  • Mika, K. Fytoterapia. Osveta, 1988. info
  • Kindl, H., Vöber, B. Biochemie rostlin. Academia Praha, 1981. info
Teaching methods
Lectures Practical excersises Discussion with teachers and brainstorming
Assessment methods
Completion of practical exercises, succesfull passing the test (min. 60%, 1 regular and 2 amendatory attempts) Practical exam - knowledge of selected drugs, knowledge of ingredients and uses Oral examination (knowledge of Phytochemistry, Pharmacognosy I a II). The number of terms is final.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
100% participation in practical exercises At least 60% success in all tests (1 standard + 2 correction attempts) Before the exam, passing a practical exam related to the recognition of 10 macroscopic and 3 microscopic preparations, description of drugs, ingredients, use and common identity tests. Knowledge of Pharmacognosy within the scope of the syllabus. The number of dates listed before the exam period is terminal, you need to plan.
The course is also listed under the following terms Spring 2020, Spring 2021, Spring 2022, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2023/F1FG2_12