C2135 Bioinformatics for practice

Faculty of Science
Spring 2026
Extent and Intensity
0/2/0. 2 credit(s) (plus extra credits for completion). Type of Completion: k (colloquium).
In-person direct teaching
Teacher(s)
Mgr. Lenka Malinovská, Ph.D. (lecturer)
Mgr. Josef Houser, Ph.D. (seminar tutor)
Guaranteed by
Mgr. Lenka Malinovská, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable of Seminar Groups
C2135/01: Mon 16. 2. to Fri 22. 5. Wed 14:00–15:50 B09/316
C2135/02: Mon 16. 2. to Fri 22. 5. Wed 16:00–17:50 B09/316
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
At the end of the course students should be able to: search for information and work with biological databases; perform independent bioinformatic analyses of data; prepare experimental project focused on protein cloning
Learning outcomes
At the end of the course students should: 1) Obtain basic knowledge of bioinformatics. Students should be able to: 1) Process bioinformational data. 2) Predict basic properties of biomacromolecules. 3) Utilize bioinformational tools for solving of biological problems.
Key topics
  • Information search. General search, biological databases. Criminality associated with scientific literature. 
  • Sequence alignment. Parameters (gaps, matrix). Nucleotide vs. amino acid alignments. Repetitions. Alignment as a tool for sequencing data analyses.
  • Gene prediction, prediction of proteins and their functions. Protein structure prediction.
  • Primer design. Their importance, basic characteristics, secondary structure prediction, false priming, design of specific primers.
  • Cloning and restriction endonucleases digestion.
  • Protein properties prediction. Possibilities, comparison of demands and reliability of calculation and experiment.
  • Individual project: identification of putative genes in the genome of an unknown organism, which are important for pro virulence. Function prediction of encoded proteins.
  • Demonstration of practical exercise: Polymerase chain reaction and agarose electrophoresis.
Study resources and literature
Approaches, practices, and methods used in teaching
Practical exercises in silico, individual project
Method of verifying learning outcomes and course completion requirements
Finished individual project, group discussion about projects
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/spring2026/C2135