PřF:C3901 Mechanisms of cell ageing - Course Information
C3901 Molecular mechanisms of cell ageing
Faculty of ScienceSpring 2025
- Extent and Intensity
- 2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
- Teacher(s)
- doc. Mgr. Petra Procházková Schrumpfová, Ph.D. (lecturer)
Mgr. Eva Dvořák Tomaštíková, Ph.D. (lecturer), doc. Mgr. Petra Procházková Schrumpfová, Ph.D. (deputy) - Guaranteed by
- doc. Mgr. Petra Procházková Schrumpfová, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science - Prerequisites
- Students should have elementary knowledge of molecular or cellular biology.
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- there are 40 fields of study the course is directly associated with, display
- Course objectives
- This course is focused on the hallmarks of ageing in different organisms, with special emphasis on the molecular and cellular bases such as: deficiencies in DNA repair mechanisms in aged cells, mitochondrial dysfunction, telomere shortening, cellular senescence, alterations in epigenetic marks, loss of proteostasis, microbiome alterations, beneficial effects of dietary restriction in longevity etc. At the end we will discuss anti-ageing medicine.
- Learning outcomes
- Students will be able to explain hallmarks of ageing especially in human cells and also understand molecular mechanism of ageing in various model organisms. Each chapter starts with a short overview of the discussed issue (e.g. repair mechanisms of DNA lesions, mitochondrial or telomere functions, what is epigenetics and DNA / histone epigenetic modifications) followed by a closer description of the interconnection between the discussed topic and cellular ageing. At the end students will be able to understand the mutual interconnection of discussed chapters.
- Syllabus
- ageing in human population
- ageing in different organisms
- ageing and cancer
- theories of ageing
- stochastic nature of the ageing process
- programmed theories of ageing
- damage-based theories of ageing
- progeroid syndromes
- protein oxidation in ageing
- nuclear architecture in ageing
- telomere attrition
- mitochondrial dysfunction
- cellular senescence
- epigenetic alterations v loss of proteostasis v caloric restriction
- stem cell exhaustion
- altered intercellular communication
- the influence of the microbiome to ageing
- anti-ageing medicine
- Literature
- recommended literature
- PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra, Ivona VYCHODILOVÁ, Martina DVOŘÁČKOVÁ, Jana MAJERSKÁ, Ladislav DOKLÁDAL, Šárka SCHOŘOVÁ and Jiří FAJKUS. Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase. The Plant Journal. Hoboken (USA): Blackwell Science, 2014, vol. 77, No 5, p. 770-781. ISSN 0960-7412. Available from: https://dx.doi.org/10.1111/tpj.12428. URL info
- PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra, Miloslava FOJTOVÁ, Petr MOKROŠ, Klaus D. GRASSER and Jiří FAJKUS. Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana. CURRENT PROTEIN & PEPTIDE SCIENCE. BENTHAM SCIENCE PUBL LTD, 2011, vol. 12, No 2, p. 105-111. ISSN 1389-2037. info
- PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra, Miloslava FOJTOVÁ, Petr MOKROŠ, Klaus D. GRASSER and Jiří FAJKUS. Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana. CURRENT PROTEIN & PEPTIDE SCIENCE. BENTHAM SCIENCE PUBL LTD, 2011, vol. 12, No 2, p. 105-111. ISSN 1389-2037. info
- PEŠKA, Vratislav, Petra PROCHÁZKOVÁ SCHRUMPFOVÁ and Jiří FAJKUS. Using the Telobox to Search for Plant Telomere Binding Proteins. CURRENT PROTEIN & PEPTIDE SCIENCE. BENTHAM SCIENCE PUBL LTD, 2011, vol. 12, No 2, p. 75-83. ISSN 1389-2037. info
- MOZGOVÁ, Iva, Petra PROCHÁZKOVÁ SCHRUMPFOVÁ, Ctirad HOFR and Jiří FAJKUS. Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana. Phytochemistry. England: Pergamon-Elsevier Science Ltd, 2008, vol. 69, No 9, p. 1814-1819. ISSN 0031-9422. info
- Teaching methods
- lectures, class discussion, presentations by professionals in the ageing field
- Assessment methods
- for passing the colloquium the written test on 5-issues is needed, for passing the examination the written test is needed, the test consists of 20 questions, 50% of correct answers is needed to pass
- Language of instruction
- English
- Further comments (probably available only in Czech)
- The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: in blocks. - Teacher's information
- If fewer than ten students will be registered in the course Molecular Mechanisms of Cell Ageing, the lectures will be merged with the course C3900 and will be given in English every Wednesday in building C02, room 211, from 15:00 to 16:45.
- Enrolment Statistics (Spring 2025, recent)
- Permalink: https://is.muni.cz/course/sci/spring2025/C3901