PřF:IC061 Cyclodextrin derivatives

IC061 Cyclodextrin derivatives and enantioselective gas chromatography

Faculty of Science
Spring 2011

Extent and Intensity

1/0/0. 1 credit(s) (plus extra credits for completion). Recommended Type of Completion: z (credit). Other types of completion: zk (examination).

Teacher(s)

Prof. Jean-Philippe Bouillon (lecturer), prof. RNDr. Milan Potáček, CSc. (deputy)

Guaranteed by

Prerequisites

principle knowledge of organic and analytical chemistry

Course Enrolment Limitations

The course is offered to students of any study field.

Course objectives

Information about enantiomeric separation by gas chromatography

Syllabus

C061 Cyclodextrin derivatives and enantioselective gas chromatography The determination of enantiomeric purity of chiral drugs is essential nowadays and can be achieved conveniently by gas chromatography using chiral stationary phases based on modified cyclodextrins (CD). The reported synthetic strategy deals with the use of chemo and/or regioselective reactions from the native -cyclodextrin cyclodextrin including 3 main steps: protection of one hydroxyl group, transformation of the remaining ones and further functionalization. The last part of the presentation reports on the preparation of chiral GC columns and the evaluation of their enantioselectivity (terpens, amino acid derivatives, …).

Teaching methods

lecture with practical application

Language of instruction

English

Further comments (probably available only in Czech)

The course is taught: in blocks.