Bi8099 Fundamentals of antimicrobial therapy

Faculty of Science
Spring 2023
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
Mgr. Lucie Pokludová, Ph.D. (lecturer), doc. RNDr. Ivo Rudolf, Ph.D. (deputy)
doc. RNDr. Ivo Rudolf, Ph.D. (lecturer)
Guaranteed by
doc. RNDr. Ivo Rudolf, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: Ing. Jiřina Kučerová, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Thu 8:00–9:50 E25/209
Prerequisites
Bi7170 Medical microbiology
medical microbiology to be successfully completed
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to explain of the principles of antimicrobial policy and trends in assessments of quality, safety and efficacy of medicinal products containing antimicrobial substances, to summarize the history of chemotherapy and the use of antimicrobials, to interpret the human medicine and veterinary medicine aspects, to explain both from the European and world point of view. Students should be able to understand and explain mechanisms of action, mechanisms of resistance and genetical aspects of resistance to antimicrobial substances, to work with information on the methods of susceptibility and resistance tests in routine microbiological laboratories together with the performance of the test for specific phenotypes and markers of resistance, to understand and explain the survey of antimicrobial substances according to the pharmacological classes with detail description of chemical, microbiological and therapeutic characteristics, treatments of infection diseases with medicinal product containing antimicrobials.
Learning outcomes
Output is to gain knowledge about antimicrobial active substances used both in human and veterinary medicine, knowledges on resistance to antimicrobials, overview of the susceptibility and resistance testing methods as well as news in the area of antimicrobials.
Syllabus
  • The history of the chemotherapy and use of antibiotics The mechanisms of efficacy of antimicrobial substances The resistance to antimicrobials mechanisms The resistance to antimicrobials genetics and resistance transfers The resistance from the aspect of therapy in human medicine communities and hospitals The resistance from the aspect of therapy in veterinary medicine The laboratory checking of the antimicrobial therapy Specifics of laboratory checking regarding to the species of microorganisms The survey of antimicrobials according to pharmacologic groups and aspects of use of antimicrobial products in human and veterinary medicine The principles of antimicrobial therapy, specific of pregnant women and children use of antibiotics The human antibiotic health care policy in the Czech Republic The veterinary health care strategy in the Czech Republic Adverse reactions in use of antimicrobial drugs The development of new antimicrobials, marketing authorization of medicinal products for human and veterinary use Aspects of checking of veterinary antimicrobials
Literature
  • 6. White, D.G., Alekshun, M.N., McDermott, P.F. (2005): Frontiers in Antimicrobial resistance, ASM Press, Washington, D.C., 570 s.
  • Antimicrobial Resistance in Bacteria from Livestock and Companion Animals (ASM Books) 1st Edition by Frank M. Aarestrup Stefan Schwarz (Editor), Lina Maria Cavaco (Editor), Jianzhong Shen (Editor), 2018, ISBN - 13: 978-1555819798
  • 1. Aarestrup, F.M. (ed.), (2006) Antimicrobial resistance in bacteria of animal origin. , ASM Press, Washington, D.C., 442 s.
  • 5. Šimůnek, J., Smola, J. (2007): Antimikrobiální léčiva ve veterinární medicíně, Prion, 251s
  • ŠTEFAN, Marek. Antibiotika v klinické praxi. První vydání. Praha: Galén, 2019, 312 stran. ISBN 9788074923975. info
  • BENEŠ, Jiří. Antibiotika : systematika, vlastnosti, použití. 1. vydání. Praha: Grada Publishing, 2018, 598 stran. ISBN 9788027106363. info
Teaching methods
Lectures
Assessment methods
Oral or written examination
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2023, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2023/Bi8099