Bi4025en Molecular Biology

Faculty of Science
Spring 2021

The course is not taught in Spring 2021

Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jan Šmarda, CSc. (lecturer)
Guaranteed by
prof. RNDr. Jan Šmarda, CSc.
Department of Experimental Biology - Biology Section - Faculty of Science
Contact Person: prof. RNDr. Jan Šmarda, CSc.
Supplier department: Department of Experimental Biology - Biology Section - Faculty of Science
Prerequisites
(! Bi4020 Molecular biology ) && (! Bi4010 Essential molecular biology ) && ! NOWANY ( Bi4010 Essential molecular biology , Bi4020 Molecular biology )
Basic knowledge of genetics, physiology, organic chemistry and biochemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to familiarize students with structure of genomes of various organisms, to describe the way how genetic information is stored in them, how this information is stored and expressed. In addition, the course aims to provide information how the genetic information can be changed and what this implies for phenotype of the organism.
Learning outcomes
Students will be able to understand and explain basic principles of molecular biology and genetics on molecular level and their basic phenomena - the structure, replication, expression and changes of genes.
Syllabus
  • 1. Definition and brief history o molecular biology. 2. Nucleic acids: primary, secondary and tertiary structure of nucleic acids, conformation of DNA and RNA, different conformations of DNA and their significance for biological systems, genetic information and genetic code 3. Molecular structure and replication of procaryotic and eukaryotic genomes 4. Transcription of prokaryotic and eukaryotic genomes, posttranscriptional modifications and processing of RNA, mechanisms of RNA splicing and self-splicing 5. Translation of prokaryotic and eukaryotic mRNAs 6. Posttranslational processing od proteins 7. Regulation of gene expression in prokaryotes and eukaryotes 8. Molecular mechanisms of mutagenesis and recombination 9. Molecular basis of cancerogenesis (oncogenes, antioncogenes. 10. DNA Repair mechanisms 11 Mobile genetic elements, transposons and retrotransposons. 12. Basic principles of genetic engineering
Literature
    recommended literature
  • ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014. xxxiv, 134. ISBN 9780815344322. info
Teaching methods
Oral lectures illustrated by schemes and tables based on power-point presentations that are available to course participants on IS MUNI.
Assessment methods
Attending the lectures is not obligatory. The exam is based on a written test. Students are supposed to answer 50 questions covering main topics of the lectures. To pass the exam the students have to answer at least 60% of the questions correctly.
Language of instruction
English
Further Comments
The course is taught annually.
The course is taught: every week.

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