aZLFA0722c Pharmacology II - practice

Faculty of Medicine
autumn 2020
Extent and Intensity
0/2/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
Mgr. Jana Merhautová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
doc. PharmDr. Jana Rudá, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
aZLFA0621c Pharmacology I - pract. && aZLPA0622c Pathology II - practice && aZLPF0622c Pathophysiol. II - practice && aZLOR0641c Orthodontics I -pract. && aZLPD0631c Periodontology I - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students will know pharmacological characteristics of analgesics, anti-inflammatory drugs, anticancer drugs, local and general anesthetics, psychotropics and antihypertensive agents, anticoagulants and thrombolytics, antibacterial, antiviral and antifungal agents. Students will be able to prescribe ready made preparations.
Learning outcomes
Students will know the principles of drug prescription. They will be familiar with pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to drugs used in dentistry.
Syllabus
  • Day 1
  • 1/ OPIOID ANALGESICS.
  • Analgesics of morphine type. Pharmacotherapy of pain.
  • Prescription of narcotic and psychotropic agents - revision. Special prescription and practical use of analgesic preparations.
  • 2/ NON-OPIOID ANALGESICS, NON-STEROIDAL ANTIINFLAMMATORY DRUGS.
  • Classification, modes of action, topically applied antiinflammatory drugs. Special prescription of antiinflammatory drugs and antipyretics.
  • Getting ready for the next lesson: Revision of patophysiology of cancer diseases.
  • Day 2
  • 3/ ANTICANCER DRUGS
  • Overview, classification and mechanisms of action of anticancer drugs.
  • 4/ LOCAL AND GENERAL ANAESTHETICS.
  • Overview, classification and mechanisms of action, side effects.
  • Special prescription of local anaesthetics.
  • Getting ready for the next lesson: Basic psychic functions, receptors of CNS. Physiology of blood pressure regulation. Revision of PNS pharmacology-α1 sympatholytics, α2 sympathomimetics, β sympatholytics. Revision of physiology of Renin – Angiotensin – Aldosterone System.
  • Day 3
  • 5/ PSYCHOTROPIC DRUGS.
  • Classification and terminology of psychotropics. Review of their mechanisms of action.Pharmacology of anxiolytics and hypnosedatives. Mechanism of action of benzodiazepines. Drugs used for premedication and to sedate a patient before surgery.
  • Special prescription of hypnosedatives and psychostimulants, samples of herbal drugs.
  • Video-programme: Benzodiazepines.
  • 6/ANTIHYPERTENSIVE AGENTS.
  • Introduction, classification, diuretics, beta blockers, ACE inhibitors, Ca 2+ blockers, and other hypertensives.
  • Getting ready for the next lesson: Classification of antimicrobial agents, mechanisms of resistance, mechanisms of effects of antibacterial agents.
  • Day 4
  • 7/ DRUGS USED IN DISORDERS OF BLOOD CLOTTING-ANTICOAGULANTS AND THROMBOLYTICSPSYCHOTROPIC DRUGS.
  • Classification of drugs affecting haemostasis, mechanisms of action, side effects, overview of drugs.
  • Prescription of individually prepared and ready made preparations – practice.
  • 8/ ANTIBACTERIAL AGENTS.
  • Basic classification, mechanisms of action.
  • ANTIBACTERIAL, ANTIVIRAL AND ANTIFUNGAL AGENTS – focusing on the treatment of diseases of the oral cavity.
  • Special prescription of individually prepared and ready made preparations – antibiotics.
  • Getting ready for the next lesson: Revision of praescription of selected groups of drugs (lessons 1 – 8 + + semester I). Revision of taught topics (lessons 1 – 8).
  • Day 5
  • 9/ FINAL PRESCRIPTION TEST
  • REVIEW OF DRUGS WITH LOCAL ACTION USED IN DENTISTRY (repetition from the spring semester) + SELECTED CASE REPORTS ON DRUGS FROM PREVIOUS LESSONS
  • Working on PC: Solving case reports.
  • Prescription of individually prepared and ready made preparations used in dentistry.
  • 10/ FINAL (CREDIT) TEST OF SPECIAL PHARMACOLOGY (groups of drugs from lessons 1 – 8)
  • SELECTED CASE REPORTS ON DRUGS FROM PREVIOUS LESSONS
  • Working on PC: Solving case reports.
  • CREDITS.
Literature
    required literature
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
    recommended literature
  • Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    not specified
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
Bookmarks
https://is.muni.cz/ln/tag/LF:aZLFA0722c!
Teaching methods
Drug classes specifics from the Syllabus are read firstly by the teacher and presented in video-programmes if available followed by discussion and training of drug prescription with the use of drug compendia. Approaches to "pharmacotherapeutical decisions" are practiced using the special PC programmes. Reports of students on a specific pharmacological topic followed by discussion are also included.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 2 written tests: a) test on special drug presription (assessed individually by the teacher), b) multiple-choice test on knowledge of topics taught, which usually consists of 15 questions. Each question offers one or more correct options. Criterion for successful passing the test is defined as more than half correctly answered questions.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
Information for students:

In the Final Exam students are asked to pass the ROPOT test. In the oral part of the exam students are asked to answer three randomly chosen questions dealing with the topics listed in synopses: Pharmacology I Lectures, Pharmacology I Practicals, Pharmacology II Lectures, Pharmacology II Practicals.

EXAMPLES OF QUESTIONS DEALING WITH DRUG PRESCRIPTION:

Prescribe:

Narrow-spectrum penicillin (ready-made)

Prescribe:

Aminoglycoside preparation (ready-made)

Prescribe:

Oral analgesic preparation containing paracetamol (ready-made)

Prescribe:

Spasmolytic drug (ready-made)

Prescribe:

Non-barbiturate hypnotic drug (ready-made)

Prescribe:

Drug for treatment of hypertension (ready-made)

Prescribe:

Antirheumatic agent (ready-made)

Prescribe:

Antiemetic drug (ready-made)

Prescribe: Antitussive agent (ready-made)

Prescribe:

Ointment with corticosteroid (ready-made)

Prescribe:

Chemotherapeutic preparation against urinary infections (ready-made)

Prescribe:

Ointment with corticosteroid (ready-made)

Anti-inflammatory oral preparation (ready-made)

Prescribe:

Proton pump inhibitor for treatment of peptic ulcer disease(ready-made)

Prescribe: Non-salicylate antipyretic preparation (ready-made)

Prescribe:

Short-acting benzodiazepine hypnotic (ready-made)

Prescribe:

Antibiotic ointment (ready-made)

Prescribe:

Cardiac glycoside in injections (ready-made)

EXAMPLES OF QUESTIONS ON GENERAL PHARMACOLOGICAL PRINCIPLES:

Routes of administration - overview, characteristics

Basic pharmacokinetic parameters and processes (overview)

Drug absorption, "first pass" effect

Biovailability of drugs

Drug distribution, volume of distribution

Drug elimination

Drug biotransformation, phases of biotransformation

Effect of environment pH and pKa of drugs on the drug transfer across biological membranes

Enzyme inhibition and induction

Drug excretion

Pharmacokinetics of single, repeated and continous drug administration

Pharmacokinetics of drug oral and parenteral administration

Drug dosage forms - overview and influence on pharmacokinetics

Therapeutic drug monitoring

Dose and effect, types of doses

Pharmacogenetics, pharmacogenetic polymorphism

Mechanisms of drug action - overview, non specific mechanisms of drug action

Specific mechanisms of drug action - the target structures, on which the drug act

Adverse drug reactions (types, categories)

Drug receptors theory - types of receptors

Tolerance, tachyphylaxis

Drug addiction

Therapeutic index, therapeutic range

Influence of concomitant diseases on drug effect, polypragmasia

Drug allergy (hypersensitivity), idiosyncrasy

Drug interactions- overview, pharmacokinetic interactions

Drug interactions- overview, pharmacodynamic interactions

Factors influencing the drug effect (related to drug, related to organism)

Pharmacoterapy in pregnancy, drug teratogenicity

Pharmacotherapy in breastfeeding women, in pediatric population

Pharmacoterapy in elderly

Pharmacology, sub-branches, origin of drugs, drug names

Pharmacopoeia

Rational pharmacotherapy, drug anamnesis, compliance

Development of a new drug (Drug life cycle)

Preclinical and clinical evaluation of drugs

Pharmacovigilance

General principles of drug poisoning therapy, specific antidotes and their mechanisms of action

Principles of biological therapy - technology, requirements on the quality, registration, biosimilars

EXAMPLES OF QUESTIONS ON "DRUG CLASSES":

Antimycotics

Antivirotics

Drugs with the topic action used in stomatology - overview

Antiinfective drugs used in stomatology

Disinfectants and antiseptics

Drugs with the topic action - dermatologics, drugs used in ORL

Principles of antibiotic therapy - overview, mechanisms of action, resistance

Antibiotics for topic use

Penicillines

Cephalosporins and other beta-lactams

Aminoglycosides

Macrolides

Sulphonamides

Tetracyclines

Quinolones and nitroimidazoles

Non-steroidal antiinflammatory drugs + Analgesics - antipyretics

Drugs used in gout

General anaesthetics

Premedications and supplement general anaesthesia, analgosedation, neuroleptanalgesia

Central and peripheral myorelaxants

Ester-type local anaesthetics

Amide-type local anaesthetics

Types and techniques of local anaesthesia

Pharmacoterapy of anaphylactic shock

Antitussives, expectorants

Hypolipidemics, lipid-lowering drugs

Drugs used in heart failure

Histamine H1-blockers

Antiasthmatics

Antihypertensives - overview + ACE inhibitors, sartans, renine antagonists

Antihypertensives - overview + diuretics, alpha1-lytics

Antihypertensives - overview + beta-blockers, central antihypertensives

Antiulcer drugs

Laxatives, antidiarrhoics

Antiemetics, prokinetics

Spasmolytics, digestives

Vitamins AEDK

Hydrophilic vitamins

Psychopharmacs - overview, classification

Hypnosedatives

Antiepileptic drugs

Antipsychotics

Anxiolytics

Antidepressants

Nootropics, drugs affecting cognitive functions

Psychostimulants, hallucinogenic and delirogenic drugs

Antidysrhytmics

Cardiotonics, inotropic drugs

Alkylating cytostatics and other impacts of DNA

Antimetabolites + hormonal therapy in oncology

Bilogical treatment in oncology

Glucocorticoids

Thyroid + anti-thyroid drugs

Drugs used in osteoporosis

Sex hormones - HRT, contraceptives

Uterotonics, tocolytics

Insulins

Antidiabetics for the treatment of type 2 DM

Anticoagulants, antiplatelet drugs

Antithrombotics, trombolytics

Opioid analgesics

Drugs causing addiction and pharmacological possibilities of addiction treatment

Drugs affecting ANS - neurotransmission, receptors of ANS, basic overview

Sympathomimetic agents - basic effects and classification - direct sympathomimetics

Sympathomimetic agents - basic effects and classification - indirect sympathomimetics

Sympatholytic agents - basic effects and classification - direct sympatholytics

Sympatholytic agents - basic effects and classification - indirect sympatholytics

Cholinomimetic agents - basic effects and classification - direct cholinomimetics

Cholinomimetic agents - basic effects and classification - indirect cholinomimetics

Cholinolytic agents - basic effects and classification - direct cholinolytics (parasympatholytics, ganglioplegics)

LIST OF GENERIC NAMES –„ESSENTIAL DRUGS“:

pantoprazole

famotidine

atropine

butylscopolamine

fenpiverine, pitofenone

metoclopramide

ondansetron

lactulose

insulin lispro

metformin

glibenclamide

warfarin

enoxaparin

acetylsalicylic acid

digoxin

propafenone

amiodarone

epinephrine

norepinephrine

dopamine

ephedrine, pseudoephedrine

nitroglycerin

methyldopa

clonidine

urapidil

hydrochlorothiazide

furosemide

metoprolol

labetalol

nifedipine

verapamil

enalapril

losartan

atorvastatin

ezetimibe

nystatin

ketoconazole

methylergometrine

hexoprenaline

alfuzosin

oxytocin

dexamethasone

prednisone

doxycycline, chloramphenicol

amoxicillin

phenoxymethylpenicillin

oxacillin

piperacillin, co-piperacillin

cefuroxime

cotrimoxazole

clarithromycin

gentamicin

ciprofloxacin

fluconazole

aciclovir

zidovudine

cyclophosphamide

methotrexate

6-mercaptopurine

5-fluorouracil

paclitaxel

doxorubicin

cisplatin

trastuzumab

tamoxifen

interferon alpha

ibuprofen

diclofenac

indomethacin

nimesulide

suxamethonium

allopurinol

alendronic acid

lidocaine

procaine

trimecaine

articaine

sevoflurane

thiopental

propofol

dihydrocodeine

sufentanil

piritramide

tramadol

paracetamol (acetaminophen)

metamizole

sumatriptan

valproic acid

gabapentin

haloperidol

risperidone

olanzapine

lithium

diazepam

alprazolam

zolpidem

midazolam

escitalopram

amitriptyline

bupropion

methylphenidate

donepezil

physostigmine

methadone

buprenorphine

betahistine

oxymetazoline, xylometazoline

phenylephrine

salbutamol

fenoterol

ipratropium bromide

nedocromil

acetylcysteine

bromhexine

codeine

butamirate

bisulepine

cetirizine

desloratadine

pilocarpine

timolol

tropicamide

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019.
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