aFAFT1_13 Pharmaceutical Technology I

Farmaceutická fakulta
jaro 2026

Předmět se v období jaro 2026 nevypisuje.

Rozsah
2/0/0. 28p. 3 kr. Ukončení: zk.
Vyučující
PharmDr. Jan Elbl, Ph.D. (přednášející)
doc. PharmDr. Jan Gajdziok, Ph.D. (přednášející)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (přednášející)
PharmDr. Jan Elbl, Ph.D. (cvičící)
doc. Mgr. Jan Muselík, Ph.D. (cvičící)
Mgr. Sylvie Pavloková, Ph.D. (cvičící)
PharmDr. Jiří Zeman, Ph.D. (cvičící)
Garance
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to acquaint students with the basics and principles of drug formulation, methods and processes used in the design and development of dosage forms and stability studies.
Výstupy z učení
After completing the course, the student will be able to:
– identify and classify the dosage form into one of the three generations according to the nature of the drug release;
– describe procedures leading to increased bioavailability of drugs;
– describe the production and evaluation of mucoadhesive systems, ion exchangers and biological dosage forms;
– describe the principles of 3D printing for the preparation of dosage forms;
– describe in vitro – in vivo models in drug development.
Osnova
  • Introduction to the field of pharmaceutical technology. Drug (active substance), dosage forms, medicine. The importance of biopharmacy and pharmacokinetics in the formulation and development of pharmaceuticals. Generation of dosage forms. Dosage forms of the first generation.
  • Dosage forms of the second and the third generation.
  • Physico-chemical factors influencing the effect of the drug.
  • Biological factors influencing the effect of the drug.
  • Preformulation studies, drug formulation, drug validation.
  • Increasing bioavailability of poorly water soluble drugs by their modification.
  • Increasing bioavailability of poorly water soluble drugs by technological methods facilitating drug dissolution.
  • Lipophilic formulations for increasing bioavailability of poorly water-soluble drugs.
  • Liquid-solid systems and their application in pharmacy. Dosage forms based on these systems.
  • Mucoadhesive systems and their application in pharmacy. Dosage forms based on these systems.
  • 3D printing and its application in pharmacy. Dosage forms based on this technology.
  • Ion exchangers and their application in pharmacy. Dosage forms based on ion exchangers. Production of biological dosage forms.
  • In vitro – in vivo models in drug development.
Literatura
    doporučená literatura
  • 3D & 4D printing methods for pharmaceutical manufacturing and personalised drug delivery : opportunities and challenges. Edited by Dimitrios Lamprou. Cham: Springer, 2023, xiii, 321. ISBN 9783031341182. info
  • Drug delivery : principles and applications. Edited by Binghe Wang - Longqin Hu - Teruna Siahaan. Second edition. Hoboken, New Jersey: Wiley, 2016, 1 online. ISBN 9781118833230. URL info
  • Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Edited by Patrick J. Sinko - Yashveer Singh. Sixth edition. Philadelphia: Wolters Kluwer, 2011, viii, 659. ISBN 9781609134020. info
Výukové metody
lectures
Metody hodnocení
oral exam
Vyučovací jazyk
Angličtina
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