aFAFT2_13 Pharmaceutical Technology II

Farmaceutická fakulta
podzim 2025

Předmět se v období podzim 2025 nevypisuje.

Rozsah
3/2/4. 42p+28s+56c. 7 kr. Ukončení: z.
Vyučující
doc. PharmDr. Aleš Franc, Ph.D. (přednášející)
doc. PharmDr. Jan Gajdziok, Ph.D. (přednášející)
doc. PharmDr. Kateřina Kubová, Ph.D. (přednášející)
doc. PharmDr. Ruta Masteiková, CSc. (přednášející)
PharmDr. Kateřina Brückner, Ph.D. (cvičící)
PharmDr. Hana Hořavová (cvičící)
PharmDr. Miroslava Pavelková, Ph.D. (cvičící)
PharmDr. Jakub Vysloužil, Ph.D. (cvičící)
PharmDr. Jiří Zeman, Ph.D. (cvičící)
Garance
doc. PharmDr. Kateřina Kubová, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Pharmaceutical technology is a fundamental discipline within the pharmaceutical field. The course aims to introduce students to compounding, industrial production, and quality control of medications, including excipients, technological procedures, equipment, and appropriate analytical devices. Additionally, it covers the impact of the drug's application form on its bioavailability within the organism.
Výstupy z učení
Upon successful completion of the course, students will be able to:
- theoretically know the classification, requirements, excipients, technological procedure of preparation and production of liquid dosage forms and their evaluation (solutions, emulsions, suspensions)
- theoretically know the classification, requirements, excipients, and technological procedure for the preparation and manufacture of ophthalmic, nasal, and ear preparations and their evaluation
- theoretically know the classification, requirements, excipients, and technological procedure for the preparation and manufacture of parenteral preparations and their evaluation
- theoretically know the classification, requirements, excipients, and technological procedure for the preparation and manufacture of semi-solid dosage forms and their evaluation (ointments, pastes, creams, gels)
- to determine the basic aspects of dosage forms in relation to the bioavailability of the drug
- to perform essential calculations (concentrations, doses, mixing equations, ratios, etc.)
- to check the doses of a drug in a medicinal product according to the prescription of the product according to Pharmacopoeia
- to prepare both pharmacopoeial and non-pharmacopoeial solutions, syrups, aromatic waters, suspensions, emulsions, eye drops, nasal drops, and ear drops skillfully
- to detect fundamental incompatibilities in the composition of individually formulated medicinal products
- to determine the shelf life of individually formulated medicinal products
- to select suitable packaging options for individually formulated medicinal products
- to estimate the optimal storage conditions required for individually formulated medicinal products
Osnova
SYLLABUS OF LECTURES
1. Introduction into Medical Forms and Biopharmacy. Solutions: basic methods of preparation, quality evaluation.
2. Public holiday
3. Sterilization techniques. Requirements for the preparation of sterile medications.br>4. Ophthalmic preparations - definition, classification, preparation, quality evaluation, the bioavailability of drugs from ophthalmic products.
5. Preparations intended for nasal and ear application.
6. Pharmaceutical emulsions - definition, classification, preparation, quality evaluation. Physical aspects of emulsions.
7.Pharmaceutical suspensions - definition, classification, preparation, quality evaluation.
8. Incompatibilities in liquid dosage forms.
9.Excipients for preparation of liquid dosage forms (solutions). Water for pharmaceutical purposes.
10. Herbal drug preparations - definition, classification, preparation and production, quality assessment.
11. Parenteral dosage forms.
12. Topical semisolid preparations: definition, classification, properties, excipients.
13. Topical semisolid preparations: preparation and quality evaluation.

SEMINARS, PRACTICAL TRAINING
1. Introduction to the practical training. Pharmaceutical calculations.
2. Medicinal solutions: preparation at room and higher temperature, evaluation.
3. Medicinal solutions: preparation by solubilization and chemical reaction, evaluation. Test - Pharmaceutical calculations.
4. Aromatic waters and spirits. Syrups. Infusions and decoctions. Mucilagines. Preparation and evaluation.
5. Eye drops. Preparation and evaluation.
6. Nasal and ear drops. Preparation and evaluation.
7. Consultation exercise on liquid dosage forms.
8.Emulsions. Preparation and evaluation. Test - calculations for eye and nasal medicinal products.
9. Suspensions. Preparation and evaluation. Test - emulsifiers.
10. Preparation of liquid dosage forms according to prescriptions.
11. Alternative training.
12. Credit test and testing of laboratory skills.
13. Awarding credits.
Literatura
    doporučená literatura
  • EUROPEAN PHARMACOPOEIA https://pheur.edqm.eu/home
  • Fundamentals of drug delivery. Edited by Heather A. E. Benson - Michael S. Roberts - Adrian C. Williams - Xiaow. First published. Hoboken, NJ: John Wiley & Sons, 2022, xxii, 554. ISBN 9781119769606. info
  • Advances and challenges in pharmaceutical technology : materials, process development and drug delivery strategies. Edited by Amit Kumar Nayak - Kunal Pal - Indranil Banerjee - Samarendra Maji - U. London: Academic Press, 2021, 1 online. ISBN 9780128203002. URL info
  • Drug delivery : principles and applications. Edited by Binghe Wang - Longqin Hu - Teruna Siahaan. Second edition. Hoboken, New Jersey: Wiley, 2016, 1 online. ISBN 9781118833230. URL info
Výukové metody
Lectures
Lab training
Homework
Metody hodnocení
Intermediate tests in laboratory classes (3 tests, two retakes are possible)
Systematic observation of the student during laboratory classes, preparation of reports following the teacher's instructions
Credit test (credit test has two parts, part 1 - pharmaceutical calculations (limit for passing 75%), part 2 - test - closed and open questions (especially opened) from knowledge from lectures and laboratory classes (limit for passing - 60%).
Practical testing is conducted to evaluate students' skills as part of the credit assessment. (preparation of the medicinal product - detection of incompatibilities, control of dosage, selection of the correct procedure, selection of appropriate packaging, correct labelling of the product - shelf life, storage conditions).
Vyučovací jazyk
Angličtina
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