FAFT1_14 Pharmacology I

Farmaceutická fakulta
jaro 2025
Rozsah
3/3/0. 7 kr. Ukončení: z.
Vyučováno kontaktně
Vyučující
PharmDr. Tereza Kauerová, Ph.D. (přednášející)
doc. PharmDr. Peter Kollár, Ph.D. (přednášející)
PharmDr. Tereza Kauerová, Ph.D. (cvičící)
doc. PharmDr. Peter Kollár, Ph.D. (cvičící)
Garance
doc. PharmDr. Peter Kollár, Ph.D.
Ústav farmakologie a toxikologie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.

Předmět si smí zapsat nejvýše 24 stud.
Momentální stav registrace a zápisu: zapsáno: 0/24, pouze zareg.: 0/24
Mateřské obory/plány
Cíle předmětu
Pharmacology is a science that studies interactions of medical substances and organisms on various morphological and physiological levels. It focuses on mechanisms and time progress of medicines in organisms (pharmacokinetics), and on medicines impact mechanisms on an organism (pharmacodynamics). Certain toxicology sections (science on toxins) constitute a part of the pharmacology in the area of undesirable effects as well.

Course contents: The course is divided into general pharmacological principles and special pharmacology, i.e. into drug groups classified according to their influence on the functional systems of the organism (pharmacodynamic agents).
Výstupy z učení
After completing the course the student is able to clarify the basic general rules regarding the fate of the drug in the body and the mechanisms of the drug's effect on the human body. Student can also define and characterize the properties of specific drugs - mechanisms of action, pharmacological effects, pharmacokinetic properties, side effects and interactions. The student will be able to apply the acquired knowledge about the properties of drugs in a safe and effective pharmacotherapy.
Osnova
  • General pharmacology
    Pharmacokinetics
  • Types of drug transport (translocation) in organism
  • Absorption of drugs, influencing factors
  • Distribution of drugs in organism, influencing factors
  • Distribution - physiological barriers
  • Metabolism of drugs, influencing factors
  • Mechanisms of drugs excretion, influencing factors
  • Basic pharmacokinetic parameters, calculation, practical significance in pharmacotherapy
  • Factors influencing pharmacokinetics

    Pharmacodynamics
  • Mechanisms of drugs action
  • Quantitative (graded) and quantal (population) dose (concentration)- response relationships.
  • Therapeutic index
  • Drugs interactions
  • Adverse and toxic effects of drugs
  • Drug dependence, basic types
  • Preclinical testing of drugs
  • Clinical testing of drugs
  • Pharmacology and human genome (pharmacogenomics, gene therapy)

    Special Pharmacology
    Pharmacology of the peripheral nervous system
  • Autonomic nervous system - muscarinic agonists (parasympathomimetics). Inhibitors of cholinesterase
  • Autonomic nervous system - muscarinic antagonists (parasympatholytics)
  • Autonomic nervous system - adrenoceptor agonists (sympathomimetics)
  • Autonomic nervous system - adrenoceptor antagonists (sympatholytics)

    Pharmacology of cardiovascular system
  • Pharmacotherapy of chronic heart failure
  • Antidysrhythmic drugs
  • Pharmacotherapy of coronary heart disease: Therapy of angina pectoris. Overview of therapy of acute myocardial infarction
  • Vasoactive drugs
  • Inhibitors of angiotensin-converting enzyme. Antagonists of angiotensin receptors AT1
  • Pharmacotherapy of arterial hypertension
  • Pharmacology of the kidney
  • Diuretics
  • Atherosclerosis and lipoprotein metabolism
  • Pharmacotherapy of dyslipidaemias
  • Drugs acting on haemostasis and fibrinolysis
  • Drugs acting on the haemopoietic system: Treatment of anaemia by iron, folic acid and vitamin B12.
    Overview of haemopoietic growth factors
Literatura
    povinná literatura
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN, Emma S. J. ROBINSON a James FULLERTON. Rang & Dale's pharmacology / James M. Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEvan, Emma Robinson, James Fullerton. Tenth edition. London: Elsevier, 2024, xvii, 850. ISBN 9780323873963. info
  • Whalen K. Lippincott Illustrated Reviews: Pharmacology, 7th edition. Lippincott Williams & Wilkins, USA, 2018. ISBN 978-1496384133. info
    doporučená literatura
  • Trevor A, Katzung B, Masters S., Knuidering-Hall M. Katzung & Trevor's Pharmacology Examination and Board Review. McGraw-Hill Medical, 2012. ISBN 0071789235. info
  • Katzung BG. Basic and Clinical Pharmacology. McGraw-Hill Medical, 2011. ISBN 978-0071764018. info
Výukové metody
lectures, seminars
Metody hodnocení
The criterion for passing the course is to fulfill the attendance requirement at seminars and then to pass the credit test. The condition for passing the credit test is to achieve at least 55% of the maximum possible number of points.
Vyučovací jazyk
Angličtina
Informace učitele
Conditions for successful completion of the course and obtaining credits are as follows:
1. Complete all seminars (100% Attendance is necessary) (according to Article 9, Paragraph 6 of the MU Study and Examination Regulations). In the case of excused absence – compensation for the absence from seminars would be in the form of a seminar paper (range 2–3 pages of A4 format) on a topic identical to the topic of the seminar, which a student could not attend. In the case of a long-term serious absence, it will be dealt with individually. 2. To score at least 55% to pass the credit test.
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