FAAI1_15 Analytical Chemistry I

Farmaceutická fakulta
podzim 2023
Rozsah
2/3/0. 4 kr. Ukončení: z.
Vyučující
doc. RNDr. Bc. Jiří Pazourek, Ph.D. (přednášející)
doc. RNDr. Bc. Jiří Pazourek, Ph.D. (cvičící)
Ing. Klára Odehnalová, Ph.D. (cvičící)
Tomáš Crha (cvičící), Mgr. Tomáš Crha (zástupce)
Bc. Gabriela Jelínková (pomocník)
Garance
doc. RNDr. Bc. Jiří Pazourek, Ph.D.
Ústav chemických léčiv – Ústavy – Farmaceutická fakulta
Rozvrh
Čt 10:20–12:00 44-247
  • Rozvrh seminárních/paralelních skupin:
FAAI1_15/01: každý lichý čtvrtek 13:00–18:00 44-339, J. Pazourek
Předpoklady
FAKULTA(FaF) || OBOR(MUSFaF)
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Objective of the course - aims of the course unit: To provide theoretical and practical knowledge for qualified chemical and instrumental analysis of inorganic and organic substances, including drugs, emphasizing the importance of methods in drug analysis and studying structural and physicochemical properties of substances related to their biological effect. Emphasis is placed on the formation of logical thought processes of the pharmacist important for his future professional application. In practical exercises, mastering work habits and independent approach of students to solving analytical problems is consistently required.
Výstupy z učení
After completing the course, the student will be able to: - understand the meaning and principles of classical and modern analytical chemistry - have an overview of methods of qualitative analytical chemistry - practically perform basic laboratory tests of qualitative analytical chemistry
Osnova
  • Content of the lectures 1.-3. Analytical chemistry: The goal and basic terms of the science, methods. Analytical reactions: protolytic, redox, precipitation and complexation reactions. Importance of pH. Qualitative analysis of inorganic compounds. Group reactions of cations. Group reactions of anions. Selective and specific reactions of selected pharmaceutically important ions. 1st CREDIT TEST (20 minutes) 4.-5. Qualitative analysis of organic compounds. Classical proofs and identification. Preliminary test. Classes of solubility. Elemental analysis. Identification of organic compounds: Proofs of functional groups. Determination of basic physical constants, precise measurement of pH. 2nd CREDIT TEST (20 minutes) 6.-9. Qualitative analysis of organic compounds. Instrumental methods of structure analysis UV-VIS, IR, examples 10.-12. Qualitative analysis of organic compounds. Instrumental methods of structure analysis NMR, MS, examples 3rd CREDIT TEST (20 minutes) Content of the laboratory exercises 1.+2. Organization of the exercises. Safety rules in the chemical laboratory. Group and selective reactions of cations: group reagents HCl, NaOH, NH3. Analysis of an unknown sample. 3.+4. Group and selective reactions of anions, group reagents: BaCl2, AgNO3. Analysis of an unknown sample. 5.+6. Elemental analysis, confirmation of important functional groups: alcohol, aldehydes, carboxylic acids, amines. Preliminary test, determination of the solubility class. Analysis of unknown samples. 7.+8. Refractive index measurement, determination of melting point. pH measurement - determination of a weak acid 9.+10. UV-VIS qualitative analysis of organic compounds. Analysis of an unknown sample from a UV-VIS spectrum. Spectrum of an acid-base indicator in acidic and basic pH. 11.+12. IR qualitative analysis of organic compounds. Transmission and reflection modes (ATR). Analysis of an unknown sample.
Literatura
    povinná literatura
  • Skoog, West. Fundamentals of Analytical Chemistry. URL URL info
    doporučená literatura
  • European Pharmacopoeia. URL URL info
Výukové metody
Monologic (reading, lessons, demonstration) Laboratory work
Metody hodnocení
To get credits a student must: -take part in all the laboratory exercises -submit protols from all the laboratory exercises -successful complete all three parts of the credit test (analysis of cations and anions, organic analysis, interpretation of spectra (IR, NMR, MS). 51% of correct answers is needed to pass
Vyučovací jazyk
Angličtina
Informace učitele
https://moodlinka.ics.muni.cz/course/view.php?id=3510
Další komentáře
Předmět je dovoleno ukončit i mimo zkouškové období.
Nachází se v prerekvizitách jiných předmětů
Předmět je zařazen také v obdobích podzim 2020, podzim 2021, podzim 2022, podzim 2024.