A Prospective Study in Children With a Severe Form of Atopic
Dermatitis: Clinical Outcome in Relation to Cytokine Gene
Polymorphisms

J 2012

A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms

KAYSEROVA, J.; K. SISMOVA; I. ZENTSOVA-JARESOVA; Stanislav KATINA; E. VERNEROVA et al.

Základní údaje

Originální název

A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms

Autoři

KAYSEROVA, J.; K. SISMOVA; I. ZENTSOVA-JARESOVA; Stanislav KATINA; E. VERNEROVA; A. POLOUCKOVA; S. CAPKOVA; V. MALINOVA; I. STRIZ a A. SEDIVA

Vydání

Journal of Investigational Allergology and Clinical Immunology, Spain, INTERASMA, 2012, 1018-9068

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10103 Statistics and probability

Stát vydavatele

Španělsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.887

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/12:00061081

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000302663600003

Klíčová slova anglicky

Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2013 21:47, Ing. Andrea Mikešková

Anotace

V originále

Background and Objective: The course of atopic dermatitis (AD) in childhood is characterized by typical changes in phenotype, including a shift from skin involvement to respiratory allergy usually around the third year of age. We thus designed a prospective study to monitor the outcome of severe AD and to investigate the association between cytokine gene polymorphisms and clinical manifestations. Methods: Clinical and laboratory follow-up of 94 patients with severe AD and 103 healthy controls was performed using routine methodology. Allele, genotype, and haplotype frequencies of single nucleotide polymorphisms of 13 selected cytokine/receptor genes were analyzed using PCR with sequence-specific primers. Results: In our study, genotypes of 7 polymorphisms-IL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P<.05). A significant association was also found for TNF-alpha AA and IL-4 GC haplotypes and AD. We confirm the progressive clinical improvement of AD together with a decrease in the severity index SCORAD (SCORing atopic dermatitis) during childhood (P<.05). We found significant differences between IL-4Ralpha +1902 A/G and positivity of tree pollen-specific IgE (P<.05) in the AD group. Moreover, a weak association was also found between IL-10 -819C/T and IL-10 -590A/C and the appearance of allergic rhinitis (P<0.1). Conclusions: We confirmed a clinical shift in allergic phenotype in the first 3 years of life, and showed an association between IL-4, IL-6, and IL-10 polymorphisms and AD. Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD.

Návaznosti

CZ.1.07/2.2.00/15.0203, interní kód MU

Název: Univerzitní výuka matematiky v měnícím se světě (Akronym: Univerzitní výuka matematiky)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Univerzitní výuka matematiky v měnícím se světě, 2.2 Vysokoškolské vzdělávání

Citovat

KAYSEROVA, J.; K. SISMOVA; I. ZENTSOVA-JARESOVA; Stanislav KATINA; E. VERNEROVA; A. POLOUCKOVA; S. CAPKOVA; V. MALINOVA; I. STRIZ a A. SEDIVA. A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms. Journal of Investigational Allergology and Clinical Immunology. Spain: INTERASMA, 2012, roč. 22, č. 2, s. 92-101. ISSN 1018-9068.

@article{1066983,
   author = {Kayserova, J. and Sismova, K. and ZentsovaandJaresova, I. and Katina, Stanislav and Vernerova, E. and Polouckova, A. and Capkova, S. and Malinova, V. and Striz, I. and Sediva, A.},
   article_location = {Spain},
   article_number = {2},
   keywords = {Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.},
   language = {eng},
   issn = {1018-9068},
   journal = {Journal of Investigational Allergology and Clinical Immunology},
   title = {A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms},
   url = {http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm},
   volume = {22},
   year = {2012}
}

TY  - JOUR
ID  - 1066983
AU  - Kayserova, J. - Sismova, K. - Zentsova-Jaresova, I. - Katina, Stanislav - Vernerova, E. - Polouckova, A. - Capkova, S. - Malinova, V. - Striz, I. - Sediva, A.
PY  - 2012
TI  - A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms
JF  - Journal of Investigational Allergology and Clinical Immunology
VL  - 22
IS  - 2
SP  - 92-101
EP  - 92-101
PB  - INTERASMA
SN  - 10189068
KW  - Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.
UR  - http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm
L2  - http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm
N2  - Background and Objective: The course of atopic dermatitis (AD) in childhood is characterized by typical changes in phenotype, including a shift from skin involvement to respiratory allergy usually around the third year of age. We thus designed a prospective study to monitor the outcome of severe AD and to investigate the association between cytokine gene polymorphisms and clinical manifestations. Methods: Clinical and laboratory follow-up of 94 patients with severe AD and 103 healthy controls was performed using routine methodology. Allele, genotype, and haplotype frequencies of single nucleotide polymorphisms of 13 selected cytokine/receptor genes were analyzed using PCR with sequence-specific primers. Results: In our study, genotypes of 7 polymorphisms-IL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P<.05). A significant association was also found for TNF-alpha AA and IL-4 GC haplotypes and AD. We confirm the progressive clinical improvement of AD together with a decrease in the severity index SCORAD (SCORing atopic dermatitis) during childhood (P<.05). We found significant differences between IL-4Ralpha +1902 A/G and positivity of tree pollen-specific IgE (P<.05) in the AD group. Moreover, a weak association was also found between IL-10 -819C/T and IL-10 -590A/C and the appearance of allergic rhinitis (P<0.1). Conclusions: We confirmed a clinical shift in allergic phenotype in the first 3 years of life, and showed an association between IL-4, IL-6, and IL-10 polymorphisms and AD. Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD.
ER  -

KAYSEROVA, J.; K. SISMOVA; I. ZENTSOVA-JARESOVA; Stanislav KATINA; E. VERNEROVA; A. POLOUCKOVA; S. CAPKOVA; V. MALINOVA; I. STRIZ a A. SEDIVA. A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms. \textit{Journal of Investigational Allergology and Clinical Immunology}. Spain: INTERASMA, 2012, roč.~22, č.~2, s.~92-101. ISSN~1018-9068.

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