A Prospective Study in Children With a Severe Form of Atopic
Dermatitis: Clinical Outcome in Relation to Cytokine Gene
Polymorphisms

J 2012

A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms

KAYSEROVA, J., K. SISMOVA, I. ZENTSOVA-JARESOVA, Stanislav KATINA, E. VERNEROVA et. al.

Základní údaje

Originální název

A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms

Autoři

KAYSEROVA, J. (203 Česká republika), K. SISMOVA (203 Česká republika), I. ZENTSOVA-JARESOVA (203 Česká republika), Stanislav KATINA (203 Česká republika, garant, domácí), E. VERNEROVA (203 Česká republika), A. POLOUCKOVA (203 Česká republika), S. CAPKOVA (203 Česká republika), V. MALINOVA (203 Česká republika), I. STRIZ (203 Česká republika) a A. SEDIVA (203 Česká republika)

Vydání

Journal of Investigational Allergology and Clinical Immunology, Spain, INTERASMA, 2012, 1018-9068

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10103 Statistics and probability

Stát vydavatele

Španělsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.887

Kód RIV

RIV/00216224:14310/12:00061081

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000302663600003

Klíčová slova anglicky

Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2013 21:47, Ing. Andrea Mikešková

Anotace

V originále

Background and Objective: The course of atopic dermatitis (AD) in childhood is characterized by typical changes in phenotype, including a shift from skin involvement to respiratory allergy usually around the third year of age. We thus designed a prospective study to monitor the outcome of severe AD and to investigate the association between cytokine gene polymorphisms and clinical manifestations. Methods: Clinical and laboratory follow-up of 94 patients with severe AD and 103 healthy controls was performed using routine methodology. Allele, genotype, and haplotype frequencies of single nucleotide polymorphisms of 13 selected cytokine/receptor genes were analyzed using PCR with sequence-specific primers. Results: In our study, genotypes of 7 polymorphisms-IL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P<.05). A significant association was also found for TNF-alpha AA and IL-4 GC haplotypes and AD. We confirm the progressive clinical improvement of AD together with a decrease in the severity index SCORAD (SCORing atopic dermatitis) during childhood (P<.05). We found significant differences between IL-4Ralpha +1902 A/G and positivity of tree pollen-specific IgE (P<.05) in the AD group. Moreover, a weak association was also found between IL-10 -819C/T and IL-10 -590A/C and the appearance of allergic rhinitis (P<0.1). Conclusions: We confirmed a clinical shift in allergic phenotype in the first 3 years of life, and showed an association between IL-4, IL-6, and IL-10 polymorphisms and AD. Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD.

Návaznosti

CZ.1.07/2.2.00/15.0203, interní kód MU

Název: Univerzitní výuka matematiky v měnícím se světě (Akronym: Univerzitní výuka matematiky)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Univerzitní výuka matematiky v měnícím se světě, 2.2 Vysokoškolské vzdělávání

Citovat

KAYSEROVA, J., K. SISMOVA, I. ZENTSOVA-JARESOVA, Stanislav KATINA, E. VERNEROVA, A. POLOUCKOVA, S. CAPKOVA, V. MALINOVA, I. STRIZ a A. SEDIVA. A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms. Journal of Investigational Allergology and Clinical Immunology. Spain: INTERASMA, 2012, roč. 22, č. 2, s. 92-101. ISSN 1018-9068.

@article{1066983,
   author = {Kayserova, J. and Sismova, K. and ZentsovaandJaresova, I. and Katina, Stanislav and Vernerova, E. and Polouckova, A. and Capkova, S. and Malinova, V. and Striz, I. and Sediva, A.},
   article_location = {Spain},
   article_number = {2},
   keywords = {Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.},
   language = {eng},
   issn = {1018-9068},
   journal = {Journal of Investigational Allergology and Clinical Immunology},
   title = {A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms},
   url = {http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm},
   volume = {22},
   year = {2012}
}

TY  - JOUR
ID  - 1066983
AU  - Kayserova, J. - Sismova, K. - Zentsova-Jaresova, I. - Katina, Stanislav - Vernerova, E. - Polouckova, A. - Capkova, S. - Malinova, V. - Striz, I. - Sediva, A.
PY  - 2012
TI  - A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms
JF  - Journal of Investigational Allergology and Clinical Immunology
VL  - 22
IS  - 2
SP  - 92-101
EP  - 92-101
PB  - INTERASMA
SN  - 10189068
KW  - Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.
UR  - http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm
L2  - http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm
N2  - Background and Objective: The course of atopic dermatitis (AD) in childhood is characterized by typical changes in phenotype, including a shift from skin involvement to respiratory allergy usually around the third year of age. We thus designed a prospective study to monitor the outcome of severe AD and to investigate the association between cytokine gene polymorphisms and clinical manifestations. Methods: Clinical and laboratory follow-up of 94 patients with severe AD and 103 healthy controls was performed using routine methodology. Allele, genotype, and haplotype frequencies of single nucleotide polymorphisms of 13 selected cytokine/receptor genes were analyzed using PCR with sequence-specific primers. Results: In our study, genotypes of 7 polymorphisms-IL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P<.05). A significant association was also found for TNF-alpha AA and IL-4 GC haplotypes and AD. We confirm the progressive clinical improvement of AD together with a decrease in the severity index SCORAD (SCORing atopic dermatitis) during childhood (P<.05). We found significant differences between IL-4Ralpha +1902 A/G and positivity of tree pollen-specific IgE (P<.05) in the AD group. Moreover, a weak association was also found between IL-10 -819C/T and IL-10 -590A/C and the appearance of allergic rhinitis (P<0.1). Conclusions: We confirmed a clinical shift in allergic phenotype in the first 3 years of life, and showed an association between IL-4, IL-6, and IL-10 polymorphisms and AD. Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD.
ER  -

KAYSEROVA, J., K. SISMOVA, I. ZENTSOVA-JARESOVA, Stanislav KATINA, E. VERNEROVA, A. POLOUCKOVA, S. CAPKOVA, V. MALINOVA, I. STRIZ a A. SEDIVA. A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms. \textit{Journal of Investigational Allergology and Clinical Immunology}. Spain: INTERASMA, 2012, roč.~22, č.~2, s.~92-101. ISSN~1018-9068.

Podrobný výpis o publikaci