Platelet glycoprotein GP VI 13254C allele is an independent
risk factor of premature myocardial infarction

J 2010

Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction

MOTOVSKA, Z.; J. KVASNICKA; P. WIDIMSKÝ; R. PETR; J. HAJKOVÁ et al.

Základní údaje

Originální název

Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction

Autoři

MOTOVSKA, Z.; J. KVASNICKA; P. WIDIMSKÝ; R. PETR; J. HAJKOVÁ; P. BOBCIKOVÁ; P. OSMANCIK; D. ODVODYOVA a Stanislav KATINA

Vydání

Thrombosis Research, Pergamon-Elsevier Science, 2010, 0049-3848

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10103 Statistics and probability

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.372

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/10:00061091

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1016/j.thromres.2009.09.002

UT WoS

000274937400028

Klíčová slova anglicky

myocardial infarction; risk factor; platelet glycoprotein

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 4. 2013 14:53, Ing. Andrea Mikešková

Anotace

V originále

Aim The purpose of this study was to asses the impact of haemostatic and platelet receptor gene polymorphisms as an inherited risk factor for premature onset of myocardial infarction (MI). Methods Polymorphisms of platelet receptors - GP Ia (807C>T, rs1126643), GP VI (13254T>C, rs1613662), GP IIIa (HPA-1, rs5918), PAR -1 (IVS -14A>T; rs168753), P2Y12 (34C>T, rs6785930 and H1/H2 haplotype, rs2046934), and genetic variations of the gene coding for cyclooxygenase-1 (COX-1) ( -842A>G, rs10306114 and 50C>T, rs3842787) were investigated. Mutations in the genes coding for coagulation factor V (Q506R (Leiden) mutation, rs6025) and factor II (prothrombin G20210A, rs1799963) were also determined. The prevalence of gene polymorphisms was investigated in 105 consecutive patients with premature MI. This was compared with the same gene polymorphism prevalence in a group of 132 patients in which coronary artery disease had been excluded. Genotyping was done using PCR, followed by melting curve analysis with specific fluorescent hybridization probes. Results A significant association between GP VI 13254C allele carriers and premature MI was found (p = 0.025). No other differences in prevalence of the investigated polymorphisms between the compared patient populations reached statistical significance. In a logistic regression, which took other cardiovascular risk factors into account, the significance of the GP VI 13254C allele and vascular risk was suggested (OR 1.888, 95% C.I. 1.029 to 3.464, p = 0.040). In a binary logistic regression the positive relationship between the GP VI genotype and female gender was observed (0R 3.676; 95% C.I. 1.159 to 11.628; p = 0.027). The frequencies of GP VI and GP Ia gene polymorphisms were independent of one another (p = 0.836). Conclusion The presence of the GP VI 13254C allele is an independent predictor of premature MI.

Návaznosti

CZ.1.07/2.2.00/15.0203, interní kód MU

Název: Univerzitní výuka matematiky v měnícím se světě (Akronym: Univerzitní výuka matematiky)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Univerzitní výuka matematiky v měnícím se světě, 2.2 Vysokoškolské vzdělávání

Citovat

MOTOVSKA, Z.; J. KVASNICKA; P. WIDIMSKÝ; R. PETR; J. HAJKOVÁ; P. BOBCIKOVÁ; P. OSMANCIK; D. ODVODYOVA a Stanislav KATINA. Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction. Thrombosis Research. Pergamon-Elsevier Science, 2010, roč. 125, č. 2, s. "E61"-"E64", 4 s. ISSN 0049-3848. Dostupné z: https://doi.org/10.1016/j.thromres.2009.09.002.

@article{1067003,
   author = {Motovska, Z. and Kvasnicka, J. and Widimský, P. and Petr, R. and Hajková, J. and Bobciková, P. and Osmancik, P. and Odvodyova, D. and Katina, Stanislav},
   article_number = {2},
   doi = {https://doi.org/10.1016/j.thromres.2009.09.002},
   keywords = {myocardial infarction; risk factor; platelet glycoprotein},
   language = {eng},
   issn = {0049-3848},
   journal = {Thrombosis Research},
   title = {Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction},
   url = {http://www.sciencedirect.com/science/article/pii/S0049384809003934},
   volume = {125},
   year = {2010}
}

TY  - JOUR
ID  - 1067003
AU  - Motovska, Z. - Kvasnicka, J. - Widimský, P. - Petr, R. - Hajková, J. - Bobciková, P. - Osmancik, P. - Odvodyova, D. - Katina, Stanislav
PY  - 2010
TI  - Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction
JF  - Thrombosis Research
VL  - 125
IS  - 2
SP  - "E61"-"E64"
EP  - "E61"-"E64"
PB  - Pergamon-Elsevier Science
SN  - 00493848
KW  - myocardial infarction
KW  - risk factor
KW  - platelet glycoprotein
UR  - http://www.sciencedirect.com/science/article/pii/S0049384809003934
N2  - Aim The purpose of this study was to asses the impact of haemostatic and platelet receptor gene polymorphisms as an inherited risk factor for premature onset of myocardial infarction (MI). Methods Polymorphisms of platelet receptors - GP Ia (807C>T, rs1126643), GP VI (13254T>C, rs1613662), GP IIIa (HPA-1, rs5918), PAR -1 (IVS -14A>T; rs168753), P2Y12 (34C>T, rs6785930 and H1/H2 haplotype, rs2046934), and genetic variations of the gene coding for cyclooxygenase-1 (COX-1) ( -842A>G, rs10306114 and 50C>T, rs3842787) were investigated. Mutations in the genes coding for coagulation factor V (Q506R (Leiden) mutation, rs6025) and factor II (prothrombin G20210A, rs1799963) were also determined. The prevalence of gene polymorphisms was investigated in 105 consecutive patients with premature MI. This was compared with the same gene polymorphism prevalence in a group of 132 patients in which coronary artery disease had been excluded. Genotyping was done using PCR, followed by melting curve analysis with specific fluorescent hybridization probes. Results A significant association between GP VI 13254C allele carriers and premature MI was found (p = 0.025). No other differences in prevalence of the investigated polymorphisms between the compared patient populations reached statistical significance. In a logistic regression, which took other cardiovascular risk factors into account, the significance of the GP VI 13254C allele and vascular risk was suggested (OR 1.888, 95% C.I. 1.029 to 3.464, p = 0.040). In a binary logistic regression the positive relationship between the GP VI genotype and female gender was observed (0R 3.676; 95% C.I. 1.159 to 11.628; p = 0.027). The frequencies of GP VI and GP Ia gene polymorphisms were independent of one another (p = 0.836). Conclusion The presence of the GP VI 13254C allele is an independent predictor of premature MI.
ER  -

MOTOVSKA, Z.; J. KVASNICKA; P. WIDIMSKÝ; R. PETR; J. HAJKOVÁ; P. BOBCIKOVÁ; P. OSMANCIK; D. ODVODYOVA a Stanislav KATINA. Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction. \textit{Thrombosis Research}. Pergamon-Elsevier Science, 2010, roč.~125, č.~2, s.~''E61''-''E64'', 4 s. ISSN~0049-3848. Dostupné z: https://doi.org/10.1016/j.thromres.2009.09.002.

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