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@article{1067493,
author = {Babula, Petr and Vančo, Jan and Krejčová, Ludmila and Hynek, David and Sochor, Jiří and Adam, Vojtěch and Trnková, Libuše and Hubálek, Jaromír and Kizek, René},
article_number = {8},
keywords = {Medicinal Chemistry; Nucleic Acid Interaction; Electrochemistry; Cyclic Voltammetry; Differential Pulse Voltammetry; Copper; Lawsone},
language = {eng},
issn = {1452-3981},
journal = {International Journal of Electrochemical Science},
title = {Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA},
volume = {7},
year = {2012}
}
TY - JOUR
ID - 1067493
AU - Babula, Petr - Vančo, Jan - Krejčová, Ludmila - Hynek, David - Sochor, Jiří - Adam, Vojtěch - Trnková, Libuše - Hubálek, Jaromír - Kizek, René
PY - 2012
TI - Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA
JF - International Journal of Electrochemical Science
VL - 7
IS - 8
SP - 7349-7366
EP - 7349-7366
SN - 14523981
KW - Medicinal Chemistry
KW - Nucleic Acid Interaction
KW - Electrochemistry
KW - Cyclic Voltammetry
KW - Differential Pulse Voltammetry
KW - Copper
KW - Lawsone
N2 - Metal complexes of fungal and plant secondary metabolites are in the centre of interest, especially due to their biological properties including cytotoxicity. In our work, we focused on electrochemical behaviour of seven newly prepared ternary copper(II) complexes of lawsone with additional O-donor (water) and N-donor ligands (pyridine, 2-, 3-, and 4-aminopyridine, 3-hydroxypyridine, and 3,5-dimethylpyrazole) using the methods of cyclic voltammetry and differential pulse voltammetry. In addition, we tested ability of these complexes to interact with DNA. Our results indicate that the most simple complex of lawsone - Cu(lawsone)(2)(H2O)(2)center dot 0.5H(2)O proved significant prooxidant properties, which may contribute to its cytotoxicity that has been demonstrated in recent literature. In addition, all complexes evidenced ability to interact with dsDNA. In article, possible mechanisms of these interactions are discussed.
ER -
BABULA, Petr, Jan VANČO, Ludmila KREJČOVÁ, David HYNEK, Jiří SOCHOR, Vojtěch ADAM, Libuše TRNKOVÁ, Jaromír HUBÁLEK a René KIZEK. Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA. \textit{International Journal of Electrochemical Science}. 2012, roč.~7, č.~8, s.~7349-7366. ISSN~1452-3981.
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