Behavioural and neurochemical changes induced by stress-related
conditions are counteracted by the neurokinin-2 receptor
antagonist saredutant

J 2012

Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant

TAMBURELLA, Alessandra; Gian Marco LEGGIO; Vincenzo MICALE; Andrea NAVARRIA; Claudio BUCOLO et al.

Základní údaje

Originální název

Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant

Autoři

TAMBURELLA, Alessandra; Gian Marco LEGGIO; Vincenzo MICALE; Andrea NAVARRIA; Claudio BUCOLO; Valentina CICIRATA; Filippo DRAGO a Salvatore SALOMONE

Vydání

International Journal of Neuropsychopharmacology, 2012

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Švédsko

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

DOI

https://doi.org/10.1017/S1461145712000612

Klíčová slova anglicky

Brain-derived neurotrophic factor, corticosterone, forced swim test, NK2 receptor antagonist, restraint stress

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 10. 2012 13:04, Olga Křížová

Anotace

V originále

These experiments were undertaken to assess the mechanisms underlying the antidepressant-like effects of the neurokinin-2 (NK2) receptor antagonist saredutant (SR48968) in rats tested in the forced swim test (FST), by analysing hippocampal brain-derived neurotrophic factor (BDNF) and plasma corticosterone [as index of hypothalamic-pituitary-adrenal (HPA) axis activity]. Male Wistar rats received three intraperitoneal injections over 24 h of vehicle, saredutant (5 mg/kg), citalopram (15 mg/kg), clomipramine (50 mg/kg). Rats were subjected to restraint stress (4 h) 24 h prior to the FST procedure. This stress procedure increased immobility and decreased swimming behaviour in the FST; furthermore, it lowered hippocampal BDNF protein expression and increased plasma corticosterone levels. Saredutant and clomipramine or citalopram, used here as positive controls, reduced the immobility time in the FST both under basal conditions and after stress exposure. This effect was not attributable to changes in locomotion, because locomotor activity was unchanged when assessed in the open field test. Pretreatment with paracholorophenylalanine (150 mg/kg, 72 h and 48 h prior to FST) abolished the effect of citalopram and saredutant on immobility time. At neurochemical level, saredutant attenuated activation of HPA axis in stressed animals more than clomipramine or citalopram. The behavioural effects of saredutant support the hypothesis that NK2 receptor activity is involved in stress-related disorders. These effects of saredutant may be related to normalization of the HPA axis. Moreover, saredutant increases BDNF expression in the hippocampus, confirming the role of NK2 receptor blockade in BDNF activation following stressor application.

Citovat

TAMBURELLA, Alessandra; Gian Marco LEGGIO; Vincenzo MICALE; Andrea NAVARRIA; Claudio BUCOLO; Valentina CICIRATA; Filippo DRAGO a Salvatore SALOMONE. Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant. International Journal of Neuropsychopharmacology. 2012, s. "nestránkováno", 11 s. Dostupné z: https://doi.org/10.1017/S1461145712000612.

@article{1068155,
   author = {Tamburella, Alessandra and Leggio, Gian Marco and Micale, Vincenzo and Navarria, Andrea and Bucolo, Claudio and Cicirata, Valentina and Drago, Filippo and Salomone, Salvatore},
   doi = {https://doi.org/10.1017/S1461145712000612},
   keywords = {Brain-derived neurotrophic factor, corticosterone, forced swim test, NK2 receptor antagonist, restraint stress},
   language = {eng},
   journal = {International Journal of Neuropsychopharmacology},
   title = {Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant},
   year = {2012}
}

TY  - JOUR
ID  - 1068155
AU  - Tamburella, Alessandra - Leggio, Gian Marco - Micale, Vincenzo - Navarria, Andrea - Bucolo, Claudio - Cicirata, Valentina - Drago, Filippo - Salomone, Salvatore
PY  - 2012
TI  - Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant
JF  - International Journal of Neuropsychopharmacology
SP  - "nestránkováno"
EP  - "nestránkováno"
KW  - Brain-derived neurotrophic factor, corticosterone, forced swim test, NK2 receptor antagonist, restraint stress
N2  - These experiments were undertaken to assess the mechanisms underlying the antidepressant-like effects of the neurokinin-2 (NK2) receptor antagonist saredutant (SR48968) in rats tested in the forced swim test (FST), by analysing hippocampal brain-derived neurotrophic factor (BDNF) and plasma corticosterone [as index of hypothalamic-pituitary-adrenal (HPA) axis activity]. Male Wistar rats received three intraperitoneal injections over 24 h of vehicle, saredutant (5 mg/kg), citalopram (15 mg/kg), clomipramine (50 mg/kg). Rats were subjected to restraint stress (4 h) 24 h prior to the FST procedure. This stress procedure increased immobility and decreased swimming behaviour in the FST; furthermore, it lowered hippocampal BDNF protein expression and increased plasma corticosterone levels. Saredutant and clomipramine or citalopram, used here as positive controls, reduced the immobility time in the FST both under basal conditions and after stress exposure. This effect was not attributable to changes in locomotion, because locomotor activity was unchanged when assessed in the open field test. Pretreatment with paracholorophenylalanine (150 mg/kg, 72 h and 48 h prior to FST) abolished the effect of citalopram and saredutant on immobility time. At neurochemical level, saredutant attenuated activation of HPA axis in stressed animals more than clomipramine or citalopram. The behavioural effects of saredutant support the hypothesis that NK2 receptor activity is involved in stress-related disorders. These effects of saredutant may be related to normalization of the HPA axis. Moreover, saredutant increases BDNF expression in the hippocampus, confirming the role of NK2 receptor blockade in BDNF activation following stressor application.
ER  -

TAMBURELLA, Alessandra; Gian Marco LEGGIO; Vincenzo MICALE; Andrea NAVARRIA; Claudio BUCOLO; Valentina CICIRATA; Filippo DRAGO a Salvatore SALOMONE. Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant. \textit{International Journal of Neuropsychopharmacology}. 2012, s.~''nestránkováno'', 11 s. Dostupné z: https://doi.org/10.1017/S1461145712000612.

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