| PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří PAŘENICA, Jiří JARKOVSKÝ, Petr KALA, Martin POLOCZEK, Jan MAŇOUŠEK, Krystyna KLUZ, Lenka KUBKOVÁ, Simona LITTNEROVÁ, Martin TESÁK, Ondřej TOMAN, Nikolas PÁVEK, Zdeňka ČERMÁKOVÁ, Josef TOMANDL, Anna VAŠKŮ a Jindřich ŠPINAR. The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention. Genetic Testing and Molecular Biomarkers. 2012, roč. 16, č. 10, s. 1172-1178. ISSN 1945-0265. Dostupné z: https://dx.doi.org/10.1089/gtmb.2012.0120. |
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@article{1069216,
author = {Pávková Goldbergová, Monika and Pařenica, Jiří and Jarkovský, Jiří and Kala, Petr and Poloczek, Martin and Maňoušek, Jan and Kluz, Krystyna and Kubková, Lenka and Littnerová, Simona and Tesák, Martin and Toman, Ondřej and Pávek, Nikolas and Čermáková, Zdeňka and Tomandl, Josef and Vašků, Anna and Špinar, Jindřich},
article_number = {10},
doi = {http://dx.doi.org/10.1089/gtmb.2012.0120},
keywords = {PROGNOSIS},
language = {eng},
issn = {1945-0265},
journal = {Genetic Testing and Molecular Biomarkers},
title = {The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention},
volume = {16},
year = {2012}
}
TY - JOUR
ID - 1069216
AU - Pávková Goldbergová, Monika - Pařenica, Jiří - Jarkovský, Jiří - Kala, Petr - Poloczek, Martin - Maňoušek, Jan - Kluz, Krystyna - Kubková, Lenka - Littnerová, Simona - Tesák, Martin - Toman, Ondřej - Pávek, Nikolas - Čermáková, Zdeňka - Tomandl, Josef - Vašků, Anna - Špinar, Jindřich
PY - 2012
TI - The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention
JF - Genetic Testing and Molecular Biomarkers
VL - 16
IS - 10
SP - 1172-1178
EP - 1172-1178
SN - 19450265
KW - PROGNOSIS
N2 - Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. Methods: In total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. Results: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented. Conclusion: These results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.
ER -
PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří PAŘENICA, Jiří JARKOVSKÝ, Petr KALA, Martin POLOCZEK, Jan MAŇOUŠEK, Krystyna KLUZ, Lenka KUBKOVÁ, Simona LITTNEROVÁ, Martin TESÁK, Ondřej TOMAN, Nikolas PÁVEK, Zdeňka ČERMÁKOVÁ, Josef TOMANDL, Anna VAŠKŮ a Jindřich ŠPINAR. The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention. \textit{Genetic Testing and Molecular Biomarkers}. 2012, roč.~16, č.~10, s.~1172-1178. ISSN~1945-0265. Dostupné z: https://dx.doi.org/10.1089/gtmb.2012.0120.
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