Transfer of humoral and cell-mediated immunity via colostrum in
pigs

J 2011

Transfer of humoral and cell-mediated immunity via colostrum in pigs

NECHVATALOVA, Katerina; Hana KUDLACKOVA; Lenka LEVÁ; Karolina BABÍČKOVÁ; Martin FALDYNA et al.

Základní údaje

Originální název

Transfer of humoral and cell-mediated immunity via colostrum in pigs

Autoři

NECHVATALOVA, Katerina; Hana KUDLACKOVA; Lenka LEVÁ; Karolina BABÍČKOVÁ a Martin FALDYNA

Vydání

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2011, 0165-2427

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.076

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.vetimm.2011.03.022

UT WoS

000292486400011

Klíčová slova anglicky

Colostrum; KLH; Piglets; Passive immunity; Sows

Změněno: 29. 11. 2012 11:41, Mgr. Karolina Hlavová, Ph.D.

Anotace

V originále

The first aim of our study was to obtain information on the transmission of antigen-specific antibodies from colostrum to respiratory tract mucosa in piglets. The second aim was to confirm the biological relevance of the presence of lymphocytes in colostrum and the already described fact that these cells can penetrate the intestinal barrier and “colonize” peripheral blood and lymphatic tissues of piglets. Therefore, we performed an experiment in which sows were immunized with a model antigen Keyhole Limpet Hemocyanin and their piglets were euthanized at different intervals after birth and colostrum intake. Colostrum, bronchoalveolar lavage fluid and blood samples were collected for serological detection of antigen-specific antibodies. Lymphocytes isolated from peripheral blood and lymphatic tissues (mesenteric and tracheobronchial lymph nodes and spleen) of piglets were in vitro activated with the antigen. We found that colostrum-derived antibodies can cross into the respiratory tract mucosa. Furthermore, we found that antigen-specific lymphocytes were detectable in mesenteric lymph nodes and peripheral blood, but very rarely in spleen and tracheobronchial lymph nodes.

Citovat

NECHVATALOVA, Katerina; Hana KUDLACKOVA; Lenka LEVÁ; Karolina BABÍČKOVÁ a Martin FALDYNA. Transfer of humoral and cell-mediated immunity via colostrum in pigs. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 2011, roč. 142, 1–2, s. 95-100. ISSN 0165-2427. Dostupné z: https://doi.org/10.1016/j.vetimm.2011.03.022.

@article{1075281,
   author = {Nechvatalova, Katerina and Kudlackova, Hana and Levá, Lenka and Babíčková, Karolina and Faldyna, Martin},
   article_number = {1–2},
   doi = {https://doi.org/10.1016/j.vetimm.2011.03.022},
   keywords = {Colostrum; KLH; Piglets; Passive immunity; Sows},
   issn = {0165-2427},
   journal = {VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY},
   title = {Transfer of humoral and cell-mediated immunity via colostrum in pigs},
   url = {http://www.sciencedirect.com/science/article/pii/S0165242711001164},
   volume = {142},
   year = {2011}
}

TY  - JOUR
ID  - 1075281
AU  - Nechvatalova, Katerina - Kudlackova, Hana - Levá, Lenka - Babíčková, Karolina - Faldyna, Martin
PY  - 2011
TI  - Transfer of humoral and cell-mediated immunity via colostrum in pigs
JF  - VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
VL  - 142
IS  - 1–2
SP  - 95-100
EP  - 95-100
SN  - 01652427
KW  - Colostrum
KW  - KLH
KW  - Piglets
KW  - Passive immunity
KW  - Sows
UR  - http://www.sciencedirect.com/science/article/pii/S0165242711001164
N2  - The first aim of our study was to obtain information on the transmission of antigen-specific antibodies from colostrum to respiratory tract mucosa in piglets. The second aim was to confirm the biological relevance of the presence of lymphocytes in colostrum and the already described fact that these cells can penetrate the intestinal barrier and “colonize” peripheral blood and lymphatic tissues of piglets. Therefore, we performed an experiment in which sows were immunized with a model antigen Keyhole Limpet Hemocyanin and their piglets were euthanized at different intervals after birth and colostrum intake. Colostrum, bronchoalveolar lavage fluid and blood samples were collected for serological detection of antigen-specific antibodies. Lymphocytes isolated from peripheral blood and lymphatic tissues (mesenteric and tracheobronchial lymph nodes and spleen) of piglets were in vitro activated with the antigen. We found that colostrum-derived antibodies can cross into the respiratory tract mucosa. Furthermore, we found that antigen-specific lymphocytes were detectable in mesenteric lymph nodes and peripheral blood, but very rarely in spleen and tracheobronchial lymph nodes.
ER  -

NECHVATALOVA, Katerina; Hana KUDLACKOVA; Lenka LEVÁ; Karolina BABÍČKOVÁ a Martin FALDYNA. Transfer of humoral and cell-mediated immunity via colostrum in pigs. \textit{VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY}. 2011, roč.~142, 1–2, s.~95-100. ISSN~0165-2427. Dostupné z: https://doi.org/10.1016/j.vetimm.2011.03.022.

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