KREJČÍ, Lumír, Veronika ALTMANNOVÁ, Mário ŠPÍREK a Xiaolan ZHAO. Homologous recombination and its regulation. Nucleic Acids Research. Oxford, UK: Oxford Press, 2012, roč. 40, č. 13, s. 5795-5818. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gks270. |
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@article{1077886, author = {Krejčí, Lumír and Altmannová, Veronika and Špírek, Mário and Zhao, Xiaolan}, article_location = {Oxford, UK}, article_number = {13}, doi = {http://dx.doi.org/10.1093/nar/gks270}, keywords = {DOUBLE-STRAND-BREAK; REPLICATION PROTEIN-A; DNA-DAMAGE RESPONSE; RAD51 NUCLEOPROTEIN FILAMENTS; SACCHAROMYCES-CEREVISIAE SRS2; CANCER SUSCEPTIBILITY GENE; BLOOMS-SYNDROME HELICASE; JOINT MOLECULE FORMATION; ESCHERICHIA-COLI RECA; HUMAN BRCA2 PROTEIN}, language = {eng}, issn = {0305-1048}, journal = {Nucleic Acids Research}, title = {Homologous recombination and its regulation}, volume = {40}, year = {2012} }
TY - JOUR ID - 1077886 AU - Krejčí, Lumír - Altmannová, Veronika - Špírek, Mário - Zhao, Xiaolan PY - 2012 TI - Homologous recombination and its regulation JF - Nucleic Acids Research VL - 40 IS - 13 SP - 5795-5818 EP - 5795-5818 PB - Oxford Press SN - 03051048 KW - DOUBLE-STRAND-BREAK KW - REPLICATION PROTEIN-A KW - DNA-DAMAGE RESPONSE KW - RAD51 NUCLEOPROTEIN FILAMENTS KW - SACCHAROMYCES-CEREVISIAE SRS2 KW - CANCER SUSCEPTIBILITY GENE KW - BLOOMS-SYNDROME HELICASE KW - JOINT MOLECULE FORMATION KW - ESCHERICHIA-COLI RECA KW - HUMAN BRCA2 PROTEIN N2 - Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on the control of Rad51 nucleofilaments that play a central role in HR. Some factors promote the formation of these structures while others lead to their disassembly or the use of alternative repair pathways. In this article, we review these mechanisms in both mitotic and meiotic environments and in different eukaryotic taxa, with an emphasis on yeast and mammal systems. Since mutations in several proteins that regulate Rad51 nucleofilaments are associated with cancer and cancer-prone syndromes, we discuss how understanding their functions can lead to the development of better tools for cancer diagnosis and therapy. ER -
KREJČÍ, Lumír, Veronika ALTMANNOVÁ, Mário ŠPÍREK a Xiaolan ZHAO. Homologous recombination and its regulation. \textit{Nucleic Acids Research}. Oxford, UK: Oxford Press, 2012, roč.~40, č.~13, s.~5795-5818. ISSN~0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gks270.
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