Bilateral ultrastaging of sentinel lymph node in cervical
cancer: Lowering the false-negative rate and improving the
detection of micrometastasis

J 2012

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

CIBULA, David, Nadeem R. ABU-RUSTUM, Ladislav DUŠEK, Jiří SLÁMA, Michal ZIKÁN et. al.

Základní údaje

Originální název

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

Autoři

CIBULA, David (203 Česká republika, garant), Nadeem R. ABU-RUSTUM (840 Spojené státy), Ladislav DUŠEK (203 Česká republika, domácí), Jiří SLÁMA (203 Česká republika), Michal ZIKÁN (203 Česká republika), Afra ZAAL (528 Nizozemské království), Libor ŠEVČÍK (203 Česká republika), Gemma KENTER (528 Nizozemské království), Denis QUERLEU (250 Francie), Robert JACH (616 Polsko), Anne-Sophie BATS (250 Francie), Grzegorz DYDUCH (616 Polsko), Peter GRAF (203 Česká republika), Jaroslav KLAT (203 Česká republika), Chris J.L.M. MEIJER (528 Nizozemské království), Eliane MERY (250 Francie), Rene VERHEIJEN (528 Nizozemské království) a Ronald P. ZWEEMER (528 Nizozemské království)

Vydání

Gynecologic Oncology, 2012, 0090-8258

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.929

Kód RIV

RIV/00216224:14110/12:00062393

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ygyno.2012.08.035

UT WoS

000311528500005

Klíčová slova anglicky

Cervical cancer; Sentinel lymph node; Staging

Změněno: 23. 4. 2013 00:19, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objective. To evaluate the sensitivity of sentinel node (SN) ultrastaging and to define parameters that may reduce the overall false-negative rate in women with early-stage cervical cancer. Methods. We analyzed data from a large retrospective multicenter cohort group with FIGO stages IA–IIB cervical cancer in whom at least one SN was identified and systematic pelvic lymphadenectomy was uniformly performed. All who were SN negative by initial evaluation were subjected to ultrastaging. Results. In all, 645 patients were evaluable. SN were detected bilaterally in 72% of cases and unilaterally in 28%. Patients with optimal bilateral SN detection were significantly more likely to have any metastasis detected (33.3% vs. 19.2%; Pb0.001) as well as micrometastasis detected in their SN (39.6% vs. 11.4%). SN ultrastaging resulted in a low overall false-negative rate of 2.8% (whole group) and an even lower false-negative rate of 1.3% for patients with optimal bilateral mapping. Patients with false-negative SN after ultrastaging had a higher prevalence of LVSI and more frequent unilateral SN detection. Sensitivity of SN ultrastaging was 91% (95% CI: 86%–95%) for the whole group and 97% (95% CI: 91%–99%) in the subgroup with bilateral SN detection. Conclusion. These data confirm previous observations that optimal bilateral SN detection substantially decreases the false negative rate of SN ultrastaging and increases detection of micrometastasis. In patients with bilateral SN detection, the sensitivity of SN ultrastaging is not reduced in more advanced stages of the disease. SN mapping and ultrastaging should become standard practice in the surgical management of early-stage cervical cancer.

Citovat

CIBULA, David, Nadeem R. ABU-RUSTUM, Ladislav DUŠEK, Jiří SLÁMA, Michal ZIKÁN, Afra ZAAL, Libor ŠEVČÍK, Gemma KENTER, Denis QUERLEU, Robert JACH, Anne-Sophie BATS, Grzegorz DYDUCH, Peter GRAF, Jaroslav KLAT, Chris J.L.M. MEIJER, Eliane MERY, Rene VERHEIJEN a Ronald P. ZWEEMER. Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis. Gynecologic Oncology. 2012, roč. 127, č. 3, s. 462-466. ISSN 0090-8258. Dostupné z: https://dx.doi.org/10.1016/j.ygyno.2012.08.035.

@article{1078917,
   author = {Cibula, David and AbuandRustum, Nadeem R. and Dušek, Ladislav and Sláma, Jiří and Zikán, Michal and Zaal, Afra and Ševčík, Libor and Kenter, Gemma and Querleu, Denis and Jach, Robert and Bats, AnneandSophie and Dyduch, Grzegorz and Graf, Peter and Klat, Jaroslav and Meijer, Chris J.L.M. and Mery, Eliane and Verheijen, Rene and Zweemer, Ronald P.},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.ygyno.2012.08.035},
   keywords = {Cervical cancer; Sentinel lymph node; Staging},
   language = {eng},
   issn = {0090-8258},
   journal = {Gynecologic Oncology},
   title = {Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis},
   url = {http://www.sciencedirect.com/science/article/pii/S0090825812007287},
   volume = {127},
   year = {2012}
}

TY  - JOUR
ID  - 1078917
AU  - Cibula, David - Abu-Rustum, Nadeem R. - Dušek, Ladislav - Sláma, Jiří - Zikán, Michal - Zaal, Afra - Ševčík, Libor - Kenter, Gemma - Querleu, Denis - Jach, Robert - Bats, Anne-Sophie - Dyduch, Grzegorz - Graf, Peter - Klat, Jaroslav - Meijer, Chris J.L.M. - Mery, Eliane - Verheijen, Rene - Zweemer, Ronald P.
PY  - 2012
TI  - Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis
JF  - Gynecologic Oncology
VL  - 127
IS  - 3
SP  - 462-466
EP  - 462-466
SN  - 00908258
KW  - Cervical cancer
KW  - Sentinel lymph node
KW  - Staging
UR  - http://www.sciencedirect.com/science/article/pii/S0090825812007287
L2  - http://www.sciencedirect.com/science/article/pii/S0090825812007287
N2  - Objective. To evaluate the sensitivity of sentinel node (SN) ultrastaging and to define parameters that may reduce the overall false-negative rate in women with early-stage cervical cancer. Methods. We analyzed data from a large retrospective multicenter cohort group with FIGO stages IA–IIB cervical cancer in whom at least one SN was identified and systematic pelvic lymphadenectomy was uniformly performed. All who were SN negative by initial evaluation were subjected to ultrastaging. Results. In all, 645 patients were evaluable. SN were detected bilaterally in 72% of cases and unilaterally in 28%. Patients with optimal bilateral SN detection were significantly more likely to have any metastasis detected (33.3% vs. 19.2%; Pb0.001) as well as micrometastasis detected in their SN (39.6% vs. 11.4%). SN ultrastaging resulted in a low overall false-negative rate of 2.8% (whole group) and an even lower false-negative rate of 1.3% for patients with optimal bilateral mapping. Patients with false-negative SN after ultrastaging had a higher prevalence of LVSI and more frequent unilateral SN detection. Sensitivity of SN ultrastaging was 91% (95% CI: 86%–95%) for the whole group and 97% (95% CI: 91%–99%) in the subgroup with bilateral SN detection. Conclusion. These data confirm previous observations that optimal bilateral SN detection substantially decreases the false negative rate of SN ultrastaging and increases detection of micrometastasis. In patients with bilateral SN detection, the sensitivity of SN ultrastaging is not reduced in more advanced stages of the disease. SN mapping and ultrastaging should become standard practice in the surgical management of early-stage cervical cancer.
ER  -

CIBULA, David, Nadeem R. ABU-RUSTUM, Ladislav DUŠEK, Jiří SLÁMA, Michal ZIKÁN, Afra ZAAL, Libor ŠEVČÍK, Gemma KENTER, Denis QUERLEU, Robert JACH, Anne-Sophie BATS, Grzegorz DYDUCH, Peter GRAF, Jaroslav KLAT, Chris J.L.M. MEIJER, Eliane MERY, Rene VERHEIJEN a Ronald P. ZWEEMER. Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis. \textit{Gynecologic Oncology}. 2012, roč.~127, č.~3, s.~462-466. ISSN~0090-8258. Dostupné z: https://dx.doi.org/10.1016/j.ygyno.2012.08.035.

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