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@article{1078919, author = {Poprach, Alexandr and Bortlíček, Zbyněk and Büchler, Tomáš and Melichar, Bohuslav and Lakomý, Radek and Vyzula, Rostislav and Brabec, Petr and Svoboda, Marek and Dušek, Ladislav and Gregor, Jakub}, article_number = {5}, doi = {http://dx.doi.org/10.1007/s12032-012-0286-9}, keywords = {kidney cancer; renal carcinoma; epidemiology; incidence}, language = {eng}, issn = {1357-0560}, journal = {Medical Oncology}, title = {Patients with advanced and metastatic renal cell carcinoma treated with targeted therapy in the Czech Republic: twenty cancer centres, six agents, one database}, volume = {29}, year = {2012} }
TY - JOUR ID - 1078919 AU - Poprach, Alexandr - Bortlíček, Zbyněk - Büchler, Tomáš - Melichar, Bohuslav - Lakomý, Radek - Vyzula, Rostislav - Brabec, Petr - Svoboda, Marek - Dušek, Ladislav - Gregor, Jakub PY - 2012 TI - Patients with advanced and metastatic renal cell carcinoma treated with targeted therapy in the Czech Republic: twenty cancer centres, six agents, one database JF - Medical Oncology VL - 29 IS - 5 SP - 3314-3320 EP - 3314-3320 SN - 13570560 KW - kidney cancer KW - renal carcinoma KW - epidemiology KW - incidence N2 - The incidence and mortality of renal cell carcinoma (RCC) in the Czech Republic are among the highest in the world. Several targeted agents have been recently approved for the treatment of advanced/metastatic RCC. Objective: Presentation of a national clinical database for monitoring and assessment of patients with advanced/metastatic RCC treated with targeted therapy. The RenIS (RENal Information System, http://renis.registry.cz) registry is a noninterventional post-registration database of epidemiological and clinical data of patients with RCC treated with targeted therapies in the Czech Republic. Twenty cancer centres eligible for targeted therapy administration participate in the project. As of November 2011, six agents were approved and reimbursed from public health insurance, including bevacizumab, everolimus, pazopanib, sorafenib, sunitinib, and temsirolimus. As of 10 October 2011, 1,541 patients with valid recordswere entered into the database.Comparison with population-based data from the Czech National Cancer Registry revealed that RCC patients treated with targeted therapy are significantly younger (median age at diagnosis 59 vs. 66 years). Most RenIS registry patients were treated with sorafenib and sunitinib, many patients sequentially with both agents. Over 10 % of patients were also treated with everolimus in the second or third line. Progression-free survival times achieved were comparable to phase III clinical trials. The RenIS registry has become an important tool and source of information for the management of cancer care and clinical practice, providing comprehensive data onmonitoring and assessment of RCC targeted therapy on a national level. ER -
POPRACH, Alexandr, Zbyněk BORTLÍČEK, Tomáš BÜCHLER, Bohuslav MELICHAR, Radek LAKOMÝ, Rostislav VYZULA, Petr BRABEC, Marek SVOBODA, Ladislav DUŠEK a Jakub GREGOR. Patients with advanced and metastatic renal cell carcinoma treated with targeted therapy in the Czech Republic: twenty cancer centres, six agents, one database. \textit{Medical Oncology}. roč.~29, č.~5, s.~3314-3320. ISSN~1357-0560. doi:10.1007/s12032-012-0286-9. 2012.
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