| VONDÁLOVÁ BLANÁŘOVÁ, Olga, Iva JELÍNKOVÁ, Arpad SZOEOR, Belma SKENDER, Karel SOUČEK, Viktor HORVÁTH, Alena VACULOVÁ, Ladislav ANDERA, Petr SOVA, Janos SZOELLOSI, Jiřina HOFMANOVÁ, Gyoergy VEREB a Alois KOZUBÍK. Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. Carcinogenesis. Oxford: Oxford University Press, 2011, roč. 32, č. 1, s. 42-51. ISSN 0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgq220. |
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@article{1079685,
author = {Vondálová Blanářová, Olga and Jelínková, Iva and Szoeor, Arpad and Skender, Belma and Souček, Karel and Horváth, Viktor and Vaculová, Alena and Andera, Ladislav and Sova, Petr and Szoellosi, Janos and Hofmanová, Jiřina and Vereb, Gyoergy and Kozubík, Alois},
article_location = {Oxford},
article_number = {1},
doi = {http://dx.doi.org/10.1093/carcin/bgq220},
keywords = {MEMBRANE-LIPID RAFTS; CHEMOTHERAPEUTIC-AGENTS; IN-VITRO; CASPASE-8 ACTIVATION; CARCINOMA CELLS; INHIBITORY PROTEIN; ANTITUMOR-ACTIVITY; DEATH RECEPTORS; LIGAND TRAIL; II CELLS},
language = {eng},
issn = {0143-3334},
journal = {Carcinogenesis},
title = {Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway},
volume = {32},
year = {2011}
}
TY - JOUR
ID - 1079685
AU - Vondálová Blanářová, Olga - Jelínková, Iva - Szoeor, Arpad - Skender, Belma - Souček, Karel - Horváth, Viktor - Vaculová, Alena - Andera, Ladislav - Sova, Petr - Szoellosi, Janos - Hofmanová, Jiřina - Vereb, Gyoergy - Kozubík, Alois
PY - 2011
TI - Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway
JF - Carcinogenesis
VL - 32
IS - 1
SP - 42-51
EP - 42-51
PB - Oxford University Press
SN - 01433334
KW - MEMBRANE-LIPID RAFTS
KW - CHEMOTHERAPEUTIC-AGENTS
KW - IN-VITRO
KW - CASPASE-8 ACTIVATION
KW - CARCINOMA CELLS
KW - INHIBITORY PROTEIN
KW - ANTITUMOR-ACTIVITY
KW - DEATH RECEPTORS
KW - LIGAND TRAIL
KW - II CELLS
N2 - TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can selectively trigger apoptosis in various cancer cell types. However, many cancer cells are resistant to death receptor-mediated apoptosis. Combination therapy with platinum complexes may affect TRAIL-induced signaling via modulation of various steps in apoptotic pathways. Here, we show that cisplatin or a more potent platinum(IV) complex LA-12 used in 20-fold lower concentration enhanced killing effects of TRAIL in human colon and prostate cancer cell lines via stimulation of caspase activity and overall apoptosis. Both platinum complexes increased DR5 surface expression in colon cancer cells. Small interfering RNA-mediated DR5 silencing rescued cells from sensitizing effects of platinum drugs on TRAIL-induced caspase-8 activation and apoptosis, showing the functional importance of DR5 in the effects observed. In addition, both cisplatin and LA-12 triggered the relocalization of DR4 and DR5 receptors to lipid rafts and accelerated internalization of TRAIL, which may also affect TRAIL signaling. Collectively, modulations of the initial steps of the extrinsic apoptotic pathway at the level of DR5 and plasma membrane are important for sensitization of colon and prostate cancer cells to TRAIL-induced apoptosis mediated by LA-12 and cisplatin.
ER -
VONDÁLOVÁ BLANÁŘOVÁ, Olga, Iva JELÍNKOVÁ, Arpad SZOEOR, Belma SKENDER, Karel SOUČEK, Viktor HORVÁTH, Alena VACULOVÁ, Ladislav ANDERA, Petr SOVA, Janos SZOELLOSI, Jiřina HOFMANOVÁ, Gyoergy VEREB a Alois KOZUBÍK. Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. \textit{Carcinogenesis}. Oxford: Oxford University Press, 2011, roč.~32, č.~1, s.~42-51. ISSN~0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgq220.
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