| STUDNIČKA, Jan, Eva RENCOVÁ, Pavel ROZSÍVAL, Jaroslava DUŠOVÁ, Zora DUBSKÁ, Oldřich CHRAPEK, Petr KOLÁŘ, Vít KANDRNAL, Šárka PITROVÁ a Jiří ŘEHÁK. Effects of treatment change in patients with neovascular age-related macular degeneration; Results from the Czech National Registry. Biomedical Papers. Olomouc, 2012, roč. 156, č. 4, s. 359-364. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2012.100. |
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@article{1079967,
author = {Studnička, Jan and Rencová, Eva and Rozsíval, Pavel and Dušová, Jaroslava and Dubská, Zora and Chrapek, Oldřich and Kolář, Petr and Kandrnal, Vít and Pitrová, Šárka and Řehák, Jiří},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2012.100},
keywords = {age-related macular degeneration; choroidal neovascular membrane; visual acuity; ranibizumab; pegaptanib; photodynamic therapy with verteporfin},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {Effects of treatment change in patients with neovascular age-related macular degeneration; Results from the Czech National Registry},
volume = {156},
year = {2012}
}
TY - JOUR
ID - 1079967
AU - Studnička, Jan - Rencová, Eva - Rozsíval, Pavel - Dušová, Jaroslava - Dubská, Zora - Chrapek, Oldřich - Kolář, Petr - Kandrnal, Vít - Pitrová, Šárka - Řehák, Jiří
PY - 2012
TI - Effects of treatment change in patients with neovascular age-related macular degeneration; Results from the Czech National Registry
JF - Biomedical Papers
VL - 156
IS - 4
SP - 359-364
EP - 359-364
SN - 12138118
KW - age-related macular degeneration
KW - choroidal neovascular membrane
KW - visual acuity
KW - ranibizumab
KW - pegaptanib
KW - photodynamic therapy with verteporfin
N2 - Aims. To determine the effectiveness of second line treatments in patients with neovascular AMD who did not respond adequately to primary treatment. Methods. Retrospective, multicentre assessment. The frequency of primary treatment failure and outcomes of subsequent secondary treatment were assessed according to the type of primary treatment, type of CNV and change in BCVA over a 12 month period. Results. At the time of assessment 750 entries (750 treated eyes, 725 treated patients) had follow-up longer than 12 months. A treatment change required 7.7% subjects treated with ranibizumab, 20.5% with pegaptanib and 22% with PDT and verteporfin. Average BCVA of all patients at the beginning of primary treatment was 50.7 +/- 3 letters and 43 +/- 3.5 letters in 12th month (P<0.001). The mean decrease in BCVA was 7.7 +/- 0.6 letters during the first 6 months of observation. During the next 6 months, no significant change occurred. The change of primary therapy was required on average after 6.5 +/- 2.1 months. Conclusion. BCVA loss was the most significantly decelerated in patients who received ranibizumab as a secondary therapy following unsuccessful treatment with pegaptanib sodium.
ER -
STUDNIČKA, Jan, Eva RENCOVÁ, Pavel ROZSÍVAL, Jaroslava DUŠOVÁ, Zora DUBSKÁ, Oldřich CHRAPEK, Petr KOLÁŘ, Vít KANDRNAL, Šárka PITROVÁ a Jiří ŘEHÁK. Effects of treatment change in patients with neovascular age-related macular degeneration; Results from the Czech National Registry. \textit{Biomedical Papers}. Olomouc, 2012, roč.~156, č.~4, s.~359-364. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2012.100.
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