Vitamin D and cardiovascular diseases

J 2012

Vitamin D and cardiovascular diseases

MATĚJOVSKÁ KUBEŠOVÁ, Hana, Blanka VEPŘEKOVÁ, Pavel WEBER, Katarína BIELAKOVÁ, Tereza GREGOROVÁ et. al.

Základní údaje

Originální název

Vitamin D and cardiovascular diseases

Autoři

MATĚJOVSKÁ KUBEŠOVÁ, Hana (203 Česká republika, garant, domácí), Blanka VEPŘEKOVÁ (203 Česká republika, domácí), Pavel WEBER (203 Česká republika), Katarína BIELAKOVÁ (703 Slovensko) a Tereza GREGOROVÁ (203 Česká republika)

Vydání

Kuprevich Gerontological Journal, 2012, 1990-5327

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Rusko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/12:00062647

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

hypertension - arrythmias - cardiac failure - vitamin D receptors

Změněno: 22. 3. 2013 15:52, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Lot of attention is paid to vitamin D in last few years due to brighter spectrum of influence in human organs. As a main mechanism of action are proved nuclear vitamin D receptors (VDR). More and more evidence of negative influence of vitamin D deficit on cardiovascular system appears together with low vitamin D serum levels in current population mostly due to life style with little exposition of unprotected skin to sun beams. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. There is no evidence of any association of vitamin D and cholesterol levels, on the other hand normal level of vitamin D helps to keep the triglyceride serum concentration in normal range. Hypertension is influenced negatively by low level of vitamin D due to stimulation of renin-angiotensin-aldosteron system, parathormon secretion and lower antiiflammatory and vasculoprotective effect. Conclusion. The course of cardiovascular diseases can be positively modulated by keeping vitamin D level within normal range. The adequate exposition od unprotected skin to sun is to recommend for the supplementation as a nature and effective source of vitamin D.

Návaznosti

MUNI/A/0814/2011, interní kód MU

Název: Prevence syndromů stáří (Akronym: PRESYST)

Investor: Masarykova univerzita, Prevence syndromů stáří, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

MATĚJOVSKÁ KUBEŠOVÁ, Hana, Blanka VEPŘEKOVÁ, Pavel WEBER, Katarína BIELAKOVÁ a Tereza GREGOROVÁ. Vitamin D and cardiovascular diseases. Kuprevich Gerontological Journal. 2012, roč. 3/2012, 4-5, s. 11-17, 17 s. ISSN 1990-5327.

@article{1080752,
   author = {Matějovská Kubešová, Hana and Vepřeková, Blanka and Weber, Pavel and Bielaková, Katarína and Gregorová, Tereza},
   article_number = {4-5},
   keywords = {hypertension - arrythmias - cardiac failure - vitamin D receptors},
   language = {eng},
   issn = {1990-5327},
   journal = {Kuprevich Gerontological Journal},
   title = {Vitamin D and cardiovascular diseases},
   volume = {3/2012},
   year = {2012}
}

TY  - JOUR
ID  - 1080752
AU  - Matějovská Kubešová, Hana - Vepřeková, Blanka - Weber, Pavel - Bielaková, Katarína - Gregorová, Tereza
PY  - 2012
TI  - Vitamin D and cardiovascular diseases
JF  - Kuprevich Gerontological Journal
VL  - 3/2012
IS  - 4-5
SP  - 11-17
EP  - 11-17
SN  - 19905327
KW  - hypertension - arrythmias - cardiac failure - vitamin D receptors
N2  - Lot of attention is paid to vitamin D in last few years due to brighter spectrum of influence in human organs. As a main mechanism of action are proved nuclear vitamin D receptors (VDR). More and more evidence of negative influence of vitamin D deficit on cardiovascular system appears together with low vitamin D serum levels in current population mostly due to life style with little exposition of unprotected skin to sun beams. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. There is no evidence of any association of vitamin D and cholesterol levels, on the other hand normal level of vitamin D helps to keep the triglyceride serum concentration in normal range. Hypertension is influenced negatively by low level of vitamin D due to stimulation of renin-angiotensin-aldosteron system, parathormon secretion and lower antiiflammatory and vasculoprotective effect. Conclusion. The course of cardiovascular diseases can be positively modulated by keeping vitamin D level within normal range. The adequate exposition od unprotected skin to sun is to recommend for the supplementation as a nature and effective source of vitamin D.
ER  -

MATĚJOVSKÁ KUBEŠOVÁ, Hana, Blanka VEPŘEKOVÁ, Pavel WEBER, Katarína BIELAKOVÁ a Tereza GREGOROVÁ. Vitamin D and cardiovascular diseases. \textit{Kuprevich Gerontological Journal}. 2012, roč.~3/2012, 4-5, s.~11-17, 17 s. ISSN~1990-5327.

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