2012
Response To Stimulation Of Noradrenergic System Is Distinct In Mice With Differential Coping Behaviour To Social Stress
MÁCHALOVÁ, Alena; Karel ŠLAIS a Alexandra ŠULCOVÁZákladní údaje
Originální název
Response To Stimulation Of Noradrenergic System Is Distinct In Mice With Differential Coping Behaviour To Social Stress
Autoři
Vydání
2012
Další údaje
Jazyk
angličtina
Typ výsledku
Konferenční abstrakt
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Označené pro přenos do RIV
Ne
Změněno: 15. 1. 2013 09:59, MUDr. Alena Máchalová, Ph.D.
Anotace
V originále
Case studies showed that stimulation of aggressive behaviour or hypomania can be induced by atomoxetine (TMX) stimulating selectively noradrenaline transmitter system by reuptake inhibition. The aim of present study was to clarify TMX influence on affectivity in mouse model of social behaviour.In agreement with clinical observations, induced aggressive behaviour was recorded in timid mice after acute dose of TMX. In aggressive mice, however, TMX dose-dependently decreased aggression, what has not been described yet. Although TMX is considered safe and effective treatment for children and adolescent with ADHD, caution should be used as its influence on agonistic behaviour is not elucidated sufficiently.
Návaznosti
| ED1.1.00/02.0068, projekt VaV |
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