| AGATHANGELIDIS, A., Nikos DARZENTAS, A. HADZIDIMITRIOU, X. BROCHET, F. MURRAY, X. YAN, Z. DAVIS, E. VAN GASTEL-MOL, C. TRESOLDI, Ch. CHU, N. CAHILL, V. GIUDICELLI, Boris TICHÝ, L. PEDERSEN, L. FORONI, L. BONELLO, A. JANUS, K. SMEDBY, A. ANAGNOSTOPOULOS, H. MERLE-BERAL, N. LAOUTARIS, G. JULIUSSON, P. DI CELLE, Šárka POSPÍŠILOVÁ, J. JURLANDER, Ch. GEISLER, A. TSAFTARIS, M. LEFRANC, A. LANGERAK, D. OSCIER, N. CHIORAZZI, Ch. BELESSI, F. DAVI, R. ROSENQUIST, P. GHIA a K. STAMATOPOULOS. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood. Washington, DC: American Society of Hematology, 2012, roč. 119, č. 19, s. 4467-4475. ISSN 0006-4971. Dostupné z: https://dx.doi.org/10.1182/blood-2011-11-393694. |
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@article{1082989,
author = {Agathangelidis, A. and Darzentas, Nikos and Hadzidimitriou, A. and Brochet, X. and Murray, F. and Yan, X. and Davis, Z. and van GastelandMol, E. and Tresoldi, C. and Chu, Ch. and Cahill, N. and Giudicelli, V. and Tichý, Boris and Pedersen, L. and Foroni, L. and Bonello, L. and Janus, A. and Smedby, K. and Anagnostopoulos, A. and MerleandBeral, H. and Laoutaris, N. and Juliusson, G. and di Celle, P. and Pospíšilová, Šárka and Jurlander, J. and Geisler, Ch. and Tsaftaris, A. and Lefranc, M. and Langerak, A. and Oscier, D. and Chiorazzi, N. and Belessi, Ch. and Davi, F. and Rosenquist, R. and Ghia, P. and Stamatopoulos, K.},
article_location = {Washington, DC},
article_number = {19},
doi = {http://dx.doi.org/10.1182/blood-2011-11-393694},
keywords = {HEAVY-CHAIN IIA; ANTIGEN RECEPTORS; APOPTOTIC CELLS; IMMUNOGLOBULIN; ANTIBODIES; IG; GENES; REPERTOIRE; SELECTION; SEQUENCE},
language = {eng},
issn = {0006-4971},
journal = {Blood},
title = {Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies},
volume = {119},
year = {2012}
}
TY - JOUR
ID - 1082989
AU - Agathangelidis, A. - Darzentas, Nikos - Hadzidimitriou, A. - Brochet, X. - Murray, F. - Yan, X. - Davis, Z. - van Gastel-Mol, E. - Tresoldi, C. - Chu, Ch. - Cahill, N. - Giudicelli, V. - Tichý, Boris - Pedersen, L. - Foroni, L. - Bonello, L. - Janus, A. - Smedby, K. - Anagnostopoulos, A. - Merle-Beral, H. - Laoutaris, N. - Juliusson, G. - di Celle, P. - Pospíšilová, Šárka - Jurlander, J. - Geisler, Ch. - Tsaftaris, A. - Lefranc, M. - Langerak, A. - Oscier, D. - Chiorazzi, N. - Belessi, Ch. - Davi, F. - Rosenquist, R. - Ghia, P. - Stamatopoulos, K.
PY - 2012
TI - Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
JF - Blood
VL - 119
IS - 19
SP - 4467-4475
EP - 4467-4475
PB - American Society of Hematology
SN - 00064971
KW - HEAVY-CHAIN IIA
KW - ANTIGEN RECEPTORS
KW - APOPTOTIC CELLS
KW - IMMUNOGLOBULIN
KW - ANTIBODIES
KW - IG
KW - GENES
KW - REPERTOIRE
KW - SELECTION
KW - SEQUENCE
N2 - Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However, several issues need revisiting, including the criteria for identification of BCR stereotypy and its actual frequency as well as the identification of "CLL-biased" features in BCR Ig stereotypes. To this end, we examined 7596 Ig VH (IGHV-IGHD-IGHJ) sequences from 7424 CLL patients, 3 times the size of the largest published series, with an updated version of our purpose-built clustering algorithm. We document that CLL may be subdivided into 2 distinct categories: one with stereotyped and the other with nonstereotyped BCRs, at an approximate ratio of 1:2, and provide evidence suggesting a different ontogeny for these 2 categories. We also show that subset-defining sequence patterns in CLL differ from those underlying BCR stereotypy in other B-cell malignancies. Notably, 19 major subsets contained from 20 to 213 sequences each, collectively accounting for 943 sequences or one-eighth of the cohort. Hence, this compartmentalized examination of VH sequences may pave the way toward a molecular classification of CLL with implications for targeted therapeutic interventions, applicable to a significant number of patients assigned to the same subset.
ER -
AGATHANGELIDIS, A., Nikos DARZENTAS, A. HADZIDIMITRIOU, X. BROCHET, F. MURRAY, X. YAN, Z. DAVIS, E. VAN GASTEL-MOL, C. TRESOLDI, Ch. CHU, N. CAHILL, V. GIUDICELLI, Boris TICHÝ, L. PEDERSEN, L. FORONI, L. BONELLO, A. JANUS, K. SMEDBY, A. ANAGNOSTOPOULOS, H. MERLE-BERAL, N. LAOUTARIS, G. JULIUSSON, P. DI CELLE, Šárka POSPÍŠILOVÁ, J. JURLANDER, Ch. GEISLER, A. TSAFTARIS, M. LEFRANC, A. LANGERAK, D. OSCIER, N. CHIORAZZI, Ch. BELESSI, F. DAVI, R. ROSENQUIST, P. GHIA a K. STAMATOPOULOS. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. \textit{Blood}. Washington, DC: American Society of Hematology, 2012, roč.~119, č.~19, s.~4467-4475. ISSN~0006-4971. Dostupné z: https://dx.doi.org/10.1182/blood-2011-11-393694.
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