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@article{1084655,
author = {Bulik, Martin and Jančálek, Radim and Vaníček, Jiří and Škoch, Antonín and Mechl, Marek},
article_location = {Amsterdam},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.clineuro.2012.11.002},
keywords = {Magnetic resonance spectroscopy; Metabolites; Glioma; Grade},
language = {eng},
issn = {0303-8467},
journal = {Clinical Neurology and Neurosurgery},
title = {Potential of MR spectroscopy for assessment of glioma grading},
volume = {115},
year = {2013}
}
TY - JOUR
ID - 1084655
AU - Bulik, Martin - Jančálek, Radim - Vaníček, Jiří - Škoch, Antonín - Mechl, Marek
PY - 2013
TI - Potential of MR spectroscopy for assessment of glioma grading
JF - Clinical Neurology and Neurosurgery
VL - 115
IS - 2
SP - 146-153
EP - 146-153
PB - Elsevier
SN - 03038467
KW - Magnetic resonance spectroscopy
KW - Metabolites
KW - Glioma
KW - Grade
N2 - Magnetic resonance spectroscopy (MRS) is an imaging diagnostic method based that allows non-invasive measurement of metabolites in tissues. There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids. Results: Low-grade gliomas are generally characterized by a relatively high concentration of Nacetylaspartate, low level of choline and absence of lactate and lipids. The increase in creatine concentration indicates low-grade gliomas with earlier progression and malignant transformation. Progression in grade of a glioma is reflected in the progressive decrease in the N-acetylaspartate and myo-inositol levels on the one hand and elevation in choline level up to grade III on the other. Malignant transformation of the glial tumors is also accompanied by the presence of lactate and lipids in MR spectra of grade III but mainly grade IV gliomas. It follows that MRS is a helpful method for detection of glioma regions with aggressive growth or upgrading due to favorable correlation of the choline and N-acetylaspartate levels with histopathological proliferation index Ki-67. Thus, magnetic resonance spectroscopy is also a suitable method for the targeting of brain biopsies. Conclusions: Gliomas of each grade have some specific MRS features that can be used for improvement of the diagnostic value of conventional magnetic resonance imaging in non-invasive assessment of glioma grade.
ER -
BULIK, Martin, Radim JANČÁLEK, Jiří VANÍČEK, Antonín ŠKOCH a Marek MECHL. Potential of MR spectroscopy for assessment of glioma grading. \textit{Clinical Neurology and Neurosurgery}. Amsterdam: Elsevier, 2013, roč.~115, č.~2, s.~146-153. ISSN~0303-8467. Dostupné z: https://dx.doi.org/10.1016/j.clineuro.2012.11.002.
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