MDR1 in Paroxetine-Induced Sexual Dysfunction

J 2013

MDR1 in Paroxetine-Induced Sexual Dysfunction

ŽOURKOVÁ, Alexandra; Ondřej SLANAŘ; Jiří JARKOVSKÝ; Ivana PALČÍKOVÁ; Eva PINDUROVÁ et al.

Základní údaje

Originální název

MDR1 in Paroxetine-Induced Sexual Dysfunction

Autoři

ŽOURKOVÁ, Alexandra; Ondřej SLANAŘ; Jiří JARKOVSKÝ ; Ivana PALČÍKOVÁ; Eva PINDUROVÁ a Michaela CVANOVÁ

Vydání

Journal of Sex and Marital Therapy, USA, Taylor and Francis Health Sciences, 2013, 0092-623X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.667

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00067710

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1080/0092623X.2012.668514

UT WoS

000311238400006

Klíčová slova anglicky

P-GLYCOPROTEIN; MDR1; Sexual Dysfunction

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 2. 2013 08:34, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).

Citovat

ŽOURKOVÁ, Alexandra; Ondřej SLANAŘ; Jiří JARKOVSKÝ; Ivana PALČÍKOVÁ; Eva PINDUROVÁ a Michaela CVANOVÁ. MDR1 in Paroxetine-Induced Sexual Dysfunction. Journal of Sex and Marital Therapy. USA: Taylor and Francis Health Sciences, 2013, roč. 39, č. 1, s. 71-78. ISSN 0092-623X. Dostupné z: https://doi.org/10.1080/0092623X.2012.668514.

@article{1084923,
   author = {Žourková, Alexandra and Slanař, Ondřej and Jarkovský, Jiří and Palčíková, Ivana and Pindurová, Eva and Cvanová, Michaela},
   article_location = {USA},
   article_number = {1},
   doi = {https://doi.org/10.1080/0092623X.2012.668514},
   keywords = {P-GLYCOPROTEIN; MDR1; Sexual Dysfunction},
   language = {eng},
   issn = {0092-623X},
   journal = {Journal of Sex and Marital Therapy},
   title = {MDR1 in Paroxetine-Induced Sexual Dysfunction},
   url = {http://www.tandfonline.com/doi/pdf/10.1080/0092623X.2012.668514},
   volume = {39},
   year = {2013}
}

TY  - JOUR
ID  - 1084923
AU  - Žourková, Alexandra - Slanař, Ondřej - Jarkovský, Jiří - Palčíková, Ivana - Pindurová, Eva - Cvanová, Michaela
PY  - 2013
TI  - MDR1 in Paroxetine-Induced Sexual Dysfunction
JF  - Journal of Sex and Marital Therapy
VL  - 39
IS  - 1
SP  - 71-78
EP  - 71-78
PB  - Taylor and Francis Health Sciences
SN  - 0092623X
KW  - P-GLYCOPROTEIN
KW  - MDR1
KW  - Sexual Dysfunction
UR  - http://www.tandfonline.com/doi/pdf/10.1080/0092623X.2012.668514
N2  - Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).
ER  -

ŽOURKOVÁ, Alexandra; Ondřej SLANAŘ; Jiří JARKOVSKÝ; Ivana PALČÍKOVÁ; Eva PINDUROVÁ a Michaela CVANOVÁ. MDR1 in Paroxetine-Induced Sexual Dysfunction. \textit{Journal of Sex and Marital Therapy}. USA: Taylor and Francis Health Sciences, 2013, roč.~39, č.~1, s.~71-78. ISSN~0092-623X. Dostupné z: https://doi.org/10.1080/0092623X.2012.668514.

Přehled o publikaci