| ČERNÁ, Marie, M. ČEJKOVÁ, Petronela AMBROŠOVÁ, Pavel KUKLÍNEK, Hana MELUZÍNOVÁ, Vlasta POLCAROVÁ a Pavel WEBER. HLA alleles in autoimmune diabetes mellitus with onset after 35 year. In VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss". 2011. ISSN 1594-0667. |
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@proceedings{1085404,
author = {Černá, Marie and Čejková, M. and Ambrošová, Petronela and Kuklínek, Pavel and Meluzínová, Hana and Polcarová, Vlasta and Weber, Pavel},
booktitle = {VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss"},
keywords = {LADA - HLA system - appearence after 35 y.},
language = {eng},
title = {HLA alleles in autoimmune diabetes mellitus with onset after 35 year},
year = {2011}
}
TY - CONF
ID - 1085404
AU - Černá, Marie - Čejková, M. - Ambrošová, Petronela - Kuklínek, Pavel - Meluzínová, Hana - Polcarová, Vlasta - Weber, Pavel
PY - 2011
TI - HLA alleles in autoimmune diabetes mellitus with onset after 35 year
KW - LADA - HLA system - appearence after 35 y.
N2 - We summarize that in the Central Bohemian population of the Czech Republic, the INS –23HphI A allele appears to be associated with a decrease in pancreatic beta cell secretory activity. HLA genotyping points to at least a partial difference in mechanism, which leads to T1DM and LADA development as well as a more diverse genetic predisposition in juvenile- and adult-onset diabetes. The simultaneous effect of HLA and INS-VNTR alleles/ genotypes predispose individuals to an increased risk of diabetes development.
ER -
ČERNÁ, Marie, M. ČEJKOVÁ, Petronela AMBROŠOVÁ, Pavel KUKLÍNEK, Hana MELUZÍNOVÁ, Vlasta POLCAROVÁ a Pavel WEBER. HLA alleles in autoimmune diabetes mellitus with onset after 35 year. In \textit{VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss''}. 2011. ISSN~1594-0667.
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