The PI3K/AKT Signaling Pathway Controls the Quiescence of the
Low-Rhodamine123-Retention Cell Compartment Enriched for
Melanoma Stem Cell Activity

J 2013

The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity

TOUIL, Yasmine; Thomas ZULIANI; Isabelle WOLOWCZUK; Klaudia KURANDA; Jiřina MEDALOVÁ et al.

Základní údaje

Originální název

The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity

Autoři

Vydání

Stem Cells, 2013, 1066-5099

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.133

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/13:00067735

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1002/stem.1333

UT WoS

000316624300004

Klíčová slova anglicky

Melanoma stem cells; quiescence;Rhodamine123 exclusion ; LY294002; PI3K/AKT pathway ; phenotype switching

Štítky

AKR, rivok

Změněno: 14. 4. 2014 08:44, Ing. Andrea Mikešková

Anotace

V originále

Melanoma is one of the most aggressive and extremely resistant to conventional therapies neoplasms. Recently, cellular resistance was linked to the cancer stem cell phenotype, still controversial and not well defined. In this study, we utilized a Rhodamine 123 (Rh123) exclusion assay to functionally identify stem-like cells in metastatic human melanomas and melanoma cell lines. We demonstrate that a small subset of Rh123-low-retention (Rh123low) cells is enriched for stem cell-like activities, including the ability to self-renew and produce non-stem Rh123high progeny and to form melanospheres, recapitulating the phenotypic profile of the parental tumor.

Citovat

TOUIL, Yasmine; Thomas ZULIANI; Isabelle WOLOWCZUK; Klaudia KURANDA; Jiřina MEDALOVÁ; Joris ANDRIEUX; Helene LE ROY; Laurent MORTIER; Jerome VANDOMME; Nathalie JOUY; Bernadette MASSELOT; Pascaline SEGARD; Bruno QUESNEL; Pierre FORMSTECHER a Renata POLAKOWSKA. The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity. Stem Cells. 2013, roč. 31, č. 4, s. 641-651. ISSN 1066-5099. Dostupné z: https://doi.org/10.1002/stem.1333.

@article{1085862,
   author = {Touil, Yasmine and Zuliani, Thomas and Wolowczuk, Isabelle and Kuranda, Klaudia and Medalová, Jiřina and Andrieux, Joris and Le Roy, Helene and Mortier, Laurent and Vandomme, Jerome and Jouy, Nathalie and Masselot, Bernadette and Segard, Pascaline and Quesnel, Bruno and Formstecher, Pierre and Polakowska, Renata},
   article_number = {4},
   doi = {https://doi.org/10.1002/stem.1333},
   keywords = {Melanoma stem cells; quiescence;Rhodamine123 exclusion ; LY294002; PI3K/AKT pathway ; phenotype switching},
   language = {eng},
   issn = {1066-5099},
   journal = {Stem Cells},
   title = {The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/stem.1333/abstract;jsessionid=47911ED53003824F3EA04EBCBD5A08C7.d02t04},
   volume = {31},
   year = {2013}
}

TY  - JOUR
ID  - 1085862
AU  - Touil, Yasmine - Zuliani, Thomas - Wolowczuk, Isabelle - Kuranda, Klaudia - Medalová, Jiřina - Andrieux, Joris - Le Roy, Helene - Mortier, Laurent - Vandomme, Jerome - Jouy, Nathalie - Masselot, Bernadette - Segard, Pascaline - Quesnel, Bruno - Formstecher, Pierre - Polakowska, Renata
PY  - 2013
TI  - The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity
JF  - Stem Cells
VL  - 31
IS  - 4
SP  - 641-651
EP  - 641-651
SN  - 10665099
KW  - Melanoma stem cells
KW  - quiescence;Rhodamine123 exclusion
KW  - LY294002
KW  - PI3K/AKT pathway
KW  - phenotype switching
UR  - http://onlinelibrary.wiley.com/doi/10.1002/stem.1333/abstract;jsessionid=47911ED53003824F3EA04EBCBD5A08C7.d02t04
L2  - http://onlinelibrary.wiley.com/doi/10.1002/stem.1333/abstract;jsessionid=47911ED53003824F3EA04EBCBD5A08C7.d02t04
N2  - Melanoma is one of the most aggressive and extremely resistant to conventional therapies neoplasms. Recently, cellular resistance was linked to the cancer stem cell phenotype, still controversial and not well defined. In this study, we utilized a Rhodamine 123 (Rh123) exclusion assay to functionally identify stem-like cells in metastatic human melanomas and melanoma cell lines. We demonstrate that a small subset of Rh123-low-retention (Rh123low) cells is enriched for stem cell-like activities, including the ability to self-renew and produce non-stem Rh123high progeny and to form melanospheres, recapitulating the phenotypic profile of the parental tumor.
ER  -

TOUIL, Yasmine; Thomas ZULIANI; Isabelle WOLOWCZUK; Klaudia KURANDA; Jiřina MEDALOVÁ; Joris ANDRIEUX; Helene LE ROY; Laurent MORTIER; Jerome VANDOMME; Nathalie JOUY; Bernadette MASSELOT; Pascaline SEGARD; Bruno QUESNEL; Pierre FORMSTECHER a Renata POLAKOWSKA. The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity. \textit{Stem Cells}. 2013, roč.~31, č.~4, s.~641-651. ISSN~1066-5099. Dostupné z: https://doi.org/10.1002/stem.1333.

Přehled o publikaci