TOUIL, Yasmine, Thomas ZULIANI, Isabelle WOLOWCZUK, Klaudia KURANDA, Jiřina MEDALOVÁ, Joris ANDRIEUX, Helene LE ROY, Laurent MORTIER, Jerome VANDOMME, Nathalie JOUY, Bernadette MASSELOT, Pascaline SEGARD, Bruno QUESNEL, Pierre FORMSTECHER a Renata POLAKOWSKA. The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity. Stem Cells. 2013, roč. 31, č. 4, s. 641-651. ISSN 1066-5099. Dostupné z: https://dx.doi.org/10.1002/stem.1333. |
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@article{1085862, author = {Touil, Yasmine and Zuliani, Thomas and Wolowczuk, Isabelle and Kuranda, Klaudia and Medalová, Jiřina and Andrieux, Joris and Le Roy, Helene and Mortier, Laurent and Vandomme, Jerome and Jouy, Nathalie and Masselot, Bernadette and Segard, Pascaline and Quesnel, Bruno and Formstecher, Pierre and Polakowska, Renata}, article_number = {4}, doi = {http://dx.doi.org/10.1002/stem.1333}, keywords = {Melanoma stem cells; quiescence;Rhodamine123 exclusion ; LY294002; PI3K/AKT pathway ; phenotype switching}, language = {eng}, issn = {1066-5099}, journal = {Stem Cells}, title = {The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity}, url = {http://onlinelibrary.wiley.com/doi/10.1002/stem.1333/abstract;jsessionid=47911ED53003824F3EA04EBCBD5A08C7.d02t04}, volume = {31}, year = {2013} }
TY - JOUR ID - 1085862 AU - Touil, Yasmine - Zuliani, Thomas - Wolowczuk, Isabelle - Kuranda, Klaudia - Medalová, Jiřina - Andrieux, Joris - Le Roy, Helene - Mortier, Laurent - Vandomme, Jerome - Jouy, Nathalie - Masselot, Bernadette - Segard, Pascaline - Quesnel, Bruno - Formstecher, Pierre - Polakowska, Renata PY - 2013 TI - The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity JF - Stem Cells VL - 31 IS - 4 SP - 641-651 EP - 641-651 SN - 10665099 KW - Melanoma stem cells KW - quiescence;Rhodamine123 exclusion KW - LY294002 KW - PI3K/AKT pathway KW - phenotype switching UR - http://onlinelibrary.wiley.com/doi/10.1002/stem.1333/abstract;jsessionid=47911ED53003824F3EA04EBCBD5A08C7.d02t04 L2 - http://onlinelibrary.wiley.com/doi/10.1002/stem.1333/abstract;jsessionid=47911ED53003824F3EA04EBCBD5A08C7.d02t04 N2 - Melanoma is one of the most aggressive and extremely resistant to conventional therapies neoplasms. Recently, cellular resistance was linked to the cancer stem cell phenotype, still controversial and not well defined. In this study, we utilized a Rhodamine 123 (Rh123) exclusion assay to functionally identify stem-like cells in metastatic human melanomas and melanoma cell lines. We demonstrate that a small subset of Rh123-low-retention (Rh123low) cells is enriched for stem cell-like activities, including the ability to self-renew and produce non-stem Rh123high progeny and to form melanospheres, recapitulating the phenotypic profile of the parental tumor. ER -
TOUIL, Yasmine, Thomas ZULIANI, Isabelle WOLOWCZUK, Klaudia KURANDA, Jiřina MEDALOVÁ, Joris ANDRIEUX, Helene LE ROY, Laurent MORTIER, Jerome VANDOMME, Nathalie JOUY, Bernadette MASSELOT, Pascaline SEGARD, Bruno QUESNEL, Pierre FORMSTECHER a Renata POLAKOWSKA. The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity. \textit{Stem Cells}. 2013, roč.~31, č.~4, s.~641-651. ISSN~1066-5099. Dostupné z: https://dx.doi.org/10.1002/stem.1333.
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