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@inproceedings{1086020,
author = {Ohlídalová, Dana and Pásek, Michal and Šimurda, Jiří and Christé, Georges},
booktitle = {Analysis of Biomedical Signals and Images},
keywords = {cardiac cell; transverse-axial tubular system; quantitative model},
isbn = {978-80-214-4105-7},
title = {Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte},
year = {2010}
}
TY - JOUR
ID - 1086020
AU - Ohlídalová, Dana - Pásek, Michal - Šimurda, Jiří - Christé, Georges
PY - 2010
TI - Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte
SN - 9788021441057
KW - cardiac cell
KW - transverse-axial tubular system
KW - quantitative model
N2 - A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.
ER -
OHLÍDALOVÁ, Dana, Michal PÁSEK, Jiří ŠIMURDA a Georges CHRISTÉ. Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte. Online. In \textit{Analysis of Biomedical Signals and Images}. 2010. ISBN~978-80-214-4105-7. [citováno 2024-04-23]
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