Long-term vagus nerve stimulation in children with focal
epilepsy

J 2013

Long-term vagus nerve stimulation in children with focal epilepsy

RYZÍ, Michal; Milan BRÁZDIL; Zdeněk NOVÁK; Jan CHRASTINA; Hana OŠLEJŠKOVÁ et al.

Základní údaje

Originální název

Long-term vagus nerve stimulation in children with focal epilepsy

Autoři

RYZÍ, Michal; Milan BRÁZDIL; Zdeněk NOVÁK; Jan CHRASTINA; Hana OŠLEJŠKOVÁ; Ivan REKTOR a Robert KUBA

Vydání

ACTA NEUROLOGICA SCANDINAVICA, MALDEN, USA, WILEY-BLACKWELL, 2013, 0001-6314

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.437

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00067788

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1111/ane.12009

UT WoS

000317859900006

Klíčová slova anglicky

child neurology; epilepsy; quality of life; seizures; treatment

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 5. 2013 16:52, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objectives – The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods – We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 +/- 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results – The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 +/- 0.6 per year preoperatively and 0.3 +/- 0.5 per year post-operatively. The mean number of days of urgent hospitalization per patient was 9.3 +/- 6.1 per year preoperatively and 1.3 +/- 1.8 per year postoperatively. Conclusions – Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.

Přiložené soubory

ans_vagal_child_pubmed.pdf

Požádat o autorskou verzi souboru

Citovat

RYZÍ, Michal; Milan BRÁZDIL; Zdeněk NOVÁK; Jan CHRASTINA; Hana OŠLEJŠKOVÁ; Ivan REKTOR a Robert KUBA. Long-term vagus nerve stimulation in children with focal epilepsy. ACTA NEUROLOGICA SCANDINAVICA. MALDEN, USA: WILEY-BLACKWELL, 2013, roč. 127, č. 5, s. 316-322. ISSN 0001-6314. Dostupné z: https://doi.org/10.1111/ane.12009.

@article{1087789,
   author = {Ryzí, Michal and Brázdil, Milan and Novák, Zdeněk and Chrastina, Jan and Ošlejšková, Hana and Rektor, Ivan and Kuba, Robert},
   article_location = {MALDEN, USA},
   article_number = {5},
   doi = {https://doi.org/10.1111/ane.12009},
   keywords = {child neurology; epilepsy; quality of life; seizures; treatment},
   language = {eng},
   issn = {0001-6314},
   journal = {ACTA NEUROLOGICA SCANDINAVICA},
   title = {Long-term vagus nerve stimulation in children with focal epilepsy},
   volume = {127},
   year = {2013}
}

TY  - JOUR
ID  - 1087789
AU  - Ryzí, Michal - Brázdil, Milan - Novák, Zdeněk - Chrastina, Jan - Ošlejšková, Hana - Rektor, Ivan - Kuba, Robert
PY  - 2013
TI  - Long-term vagus nerve stimulation in children with focal epilepsy
JF  - ACTA NEUROLOGICA SCANDINAVICA
VL  - 127
IS  - 5
SP  - 316-322
EP  - 316-322
PB  - WILEY-BLACKWELL
SN  - 00016314
KW  - child neurology
KW  - epilepsy
KW  - quality of life
KW  - seizures
KW  - treatment
N2  - Objectives – The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods – We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 +/- 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results – The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 +/- 0.6 per year preoperatively and 0.3 +/- 0.5 per year post-operatively. The mean number of days of urgent hospitalization per patient was 9.3 +/- 6.1 per year preoperatively and 1.3 +/- 1.8 per year postoperatively. Conclusions – Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.
ER  -

RYZÍ, Michal; Milan BRÁZDIL; Zdeněk NOVÁK; Jan CHRASTINA; Hana OŠLEJŠKOVÁ; Ivan REKTOR a Robert KUBA. Long-term vagus nerve stimulation in children with focal epilepsy. \textit{ACTA NEUROLOGICA SCANDINAVICA}. MALDEN, USA: WILEY-BLACKWELL, 2013, roč.~127, č.~5, s.~316-322. ISSN~0001-6314. Dostupné z: https://doi.org/10.1111/ane.12009.

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