Stereotactic Body Radiation Therapy for Colorectal Cancer Liver
Metastases; Early Results

J 2012

Stereotactic Body Radiation Therapy for Colorectal Cancer Liver Metastases; Early Results

BURKOŇ, Petr, Pavel ŠLAMPA, Tomáš KAZDA, Marek SLÁVIK, T. PROCHÁZKA et. al.

Basic information

Original name

Stereotactic Body Radiation Therapy for Colorectal Cancer Liver Metastases; Early Results

Name in Czech

Stereotaktická radioterapie jaterních metastáz kolorektálního karcinomu; časné výsledky

Authors

BURKOŇ, Petr (203 Czech Republic, guarantor, belonging to the institution), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution), Tomáš KAZDA (203 Czech Republic, belonging to the institution), Marek SLÁVIK (703 Slovakia, belonging to the institution), T. PROCHÁZKA (203 Czech Republic) and M. VRZAL (203 Czech Republic)

Edition

Klinická onkologie, Praha, Česká lékařská společnost J.E.Purkyně, 2012, 0862-495X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/12:00063928

Organization unit

Faculty of Medicine

Keywords (in Czech)

kolorektální karcinom – metastázy – játra – radioterapie – extrakraniální stereotaktická terapie

Keywords in English

colorectal neoplasms – neoplasm metastasis – liver – radiation therapy – stereotactic body radiotherapy

Abstract

V originále

for treatment of colorectal cancer liver metastases. Materials and Methods: From September 2009 to December 2011, 11 patients with 15 inoperable liver metastases of colorectal cancer were treated by SBRT using Varian Clinac iX linear accelerator. We treated 6 men and 5 women of age from 51 to 81 years (median 68). SBRT doses ranged from 40 to 56 Gy (median 54 Gy) and were administered in 3 to 8 fractions. Results: Local control rates at 2, 4, 6, 9 and 12 months after completion of SBRT were 100%, 91%, 91%, 67% and 50%, respectively. Disease progression-free survival rates at 2, 4, 6, 9 and 12 months were 82%, 82%, 64%, 50% and 50%, respectively. Median follow-up was 15 months. No severe side effects were attributed to the therapy. Conclusion: Our study assessed the feasibility of SBRT in selected group of patients with 1 to 3 colorectal cancer liver metastases with no other treatment option. We achieved excellent local control and very moderate acute and late side effects. Distant metastases were the most common recurrence form after SBRT. SBRT demonstrated excellent local control and resulted in occasional long-term survivors without any serious side effects of therapy.

Citovat

BURKOŇ, Petr, Pavel ŠLAMPA, Tomáš KAZDA, Marek SLÁVIK, T. PROCHÁZKA and M. VRZAL. Stereotactic Body Radiation Therapy for Colorectal Cancer Liver Metastases; Early Results. Klinická onkologie. Praha: Česká lékařská společnost J.E.Purkyně, 2012, vol. 25, SUPPL. 2, p. 2S93-2S97, 5 pp. ISSN 0862-495X.

@article{1088089,
   author = {Burkoň, Petr and Šlampa, Pavel and Kazda, Tomáš and Slávik, Marek and Procházka, T. and Vrzal, M.},
   article_location = {Praha},
   article_number = {SUPPL. 2},
   keywords = {colorectal neoplasms – neoplasm metastasis – liver – radiation therapy – stereotactic body radiotherapy},
   language = {eng},
   issn = {0862-495X},
   journal = {Klinická onkologie},
   title = {Stereotactic Body Radiation Therapy for Colorectal Cancer Liver Metastases; Early Results},
   url = {http://www.linkos.cz/files/klinicka-onkologie/174.pdf},
   volume = {25},
   year = {2012}
}

TY  - JOUR
ID  - 1088089
AU  - Burkoň, Petr - Šlampa, Pavel - Kazda, Tomáš - Slávik, Marek - Procházka, T. - Vrzal, M.
PY  - 2012
TI  - Stereotactic Body Radiation Therapy for Colorectal Cancer Liver Metastases; Early Results
JF  - Klinická onkologie
VL  - 25
IS  - SUPPL. 2
SP  - 2S93-2S97
EP  - 2S93-2S97
PB  - Česká lékařská společnost J.E.Purkyně
SN  - 0862495X
KW  - colorectal neoplasms – neoplasm metastasis – liver – radiation therapy – stereotactic body radiotherapy
UR  - http://www.linkos.cz/files/klinicka-onkologie/174.pdf
N2  - for treatment of colorectal cancer liver metastases. Materials and Methods: From September 2009 to December 2011, 11 patients with 15 inoperable liver metastases of colorectal cancer were treated by SBRT using Varian Clinac iX linear accelerator. We treated 6 men and 5 women of age from 51 to 81 years (median 68). SBRT doses ranged from 40 to 56 Gy (median 54 Gy) and were administered in 3 to 8 fractions. Results: Local control rates at 2, 4, 6, 9 and 12 months after completion of SBRT were 100%, 91%, 91%, 67% and 50%, respectively. Disease progression-free survival rates at 2, 4, 6, 9 and 12 months were 82%, 82%, 64%, 50% and 50%, respectively. Median follow-up was 15 months. No severe side effects were attributed to the therapy. Conclusion: Our study assessed the feasibility of SBRT in selected group of patients with 1 to 3 colorectal cancer liver metastases with no other treatment option. We achieved excellent local control and very moderate acute and late side effects. Distant metastases were the most common recurrence form after SBRT. SBRT demonstrated excellent local control and resulted in occasional long-term survivors without any serious side effects of therapy.
ER  -

BURKOŇ, Petr, Pavel ŠLAMPA, Tomáš KAZDA, Marek SLÁVIK, T. PROCHÁZKA and M. VRZAL. Stereotactic Body Radiation Therapy for Colorectal Cancer Liver Metastases; Early Results. \textit{Klinická onkologie}. Praha: Česká lékařská společnost J.E.Purkyně, 2012, vol.~25, SUPPL. 2, p.~2S93-2S97, 5 pp. ISSN~0862-495X.

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