Hepatitis B virus infection and risk of lymphoma: results of a
serological analysis within the European case-control study
Epilymph

J 2012

Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph

BECKER, Nikolaus; Paul SCHNITZLER; Paolo BOFFETTA; Paul BRENNAN; Lenka FORETOVÁ et al.

Základní údaje

Originální název

Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph

Autoři

BECKER, Nikolaus; Paul SCHNITZLER; Paolo BOFFETTA; Paul BRENNAN; Lenka FORETOVÁ; Marc MAYNADIE; Alexandra NIETERS; Anthony STAINES; Yolanda BENAVENTE; Pierluigi COCCO a Silvia DE SANJOSE

Vydání

Journal of cancer research and clinical oncology, Germany, Springer-Verlag, 2012, 0171-5216

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.914

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1007/s00432-012-1279-y

UT WoS

000310813200003

Klíčová slova anglicky

Chronic lymphocytic leukaemia; Diffuse large B-cell lymphoma; Follicular lymphoma; Multiple myeloma; NHL; B-NHL; T-cell lymphoma

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2014 14:15, Soňa Böhmová

Anotace

V originále

Background We have recently reported from Epilymph, a multicentre case-control study of lymphoma conducted in six European countries, a significant association between NHL and self-reported history of past or present HBV infection based on questionnaire data from face-to-face interviews. Methods To corroborate this observation, we used the data and blood specimen from Epilymph to investigate the associations between serological indicators of HBV infection with risk of Hodgkin lymphoma, non-Hodgkin lymphoma (NHL) and specific lymphoma entities. For 1,518 cases and 1,496 controls with sufficient amount of serum or plasma, we tested HBs-antigen, anti-HBc and anti-HBs to distinguish between current or past infection and immunity by vaccination. Statistical analysis was carried out with unconditional logistic regression. Results We found a positive association of a past HBV infection with multiple myeloma (MM, OR = 1.97, 95 % CL = 1.16-3.37). Non-significant associations were found between past HBV infection and B-cell chronic lymphocytic leukaemia (B-CLL, OR = 1.33, 95 % CL = 0.82-2.16) and T-cell NHL (OR = 1.59, 95 % CL = 0.65-3.90), as well as between current HBV infection and NHL (OR = 1.49, 95 % CL = 0.65-3.41), B-NHL (OR = 1.58, 95 % CL = 0.69-3.64) and diffuse large B-cell lymphoma (DLBCL, OR = 1.50, 95 % CL = 0.47-4.82). Subjects having self-reported HBV infection were serological positive in 75 % of cases and 80 % of controls. For vaccination, the corresponding figures were 49 and 54 %, respectively. Conclusion The present results support previous reports of an association between a history of HBV infection with an elevated lymphoma risk and add multiple myeloma to the list of potentially virus-associated lymphoma entities.

Citovat

BECKER, Nikolaus; Paul SCHNITZLER; Paolo BOFFETTA; Paul BRENNAN; Lenka FORETOVÁ; Marc MAYNADIE; Alexandra NIETERS; Anthony STAINES; Yolanda BENAVENTE; Pierluigi COCCO a Silvia DE SANJOSE. Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph. Journal of cancer research and clinical oncology. Germany: Springer-Verlag, 2012, roč. 138, č. 12, s. 1993-2001. ISSN 0171-5216. Dostupné z: https://doi.org/10.1007/s00432-012-1279-y.

@article{1089112,
   author = {Becker, Nikolaus and Schnitzler, Paul and Boffetta, Paolo and Brennan, Paul and Foretová, Lenka and Maynadie, Marc and Nieters, Alexandra and Staines, Anthony and Benavente, Yolanda and Cocco, Pierluigi and de Sanjose, Silvia},
   article_location = {Germany},
   article_number = {12},
   doi = {https://doi.org/10.1007/s00432-012-1279-y},
   keywords = {Chronic lymphocytic leukaemia; Diffuse large B-cell lymphoma; Follicular lymphoma; Multiple myeloma; NHL; B-NHL; T-cell lymphoma},
   language = {eng},
   issn = {0171-5216},
   journal = {Journal of cancer research and clinical oncology},
   title = {Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph},
   volume = {138},
   year = {2012}
}

TY  - JOUR
ID  - 1089112
AU  - Becker, Nikolaus - Schnitzler, Paul - Boffetta, Paolo - Brennan, Paul - Foretová, Lenka - Maynadie, Marc - Nieters, Alexandra - Staines, Anthony - Benavente, Yolanda - Cocco, Pierluigi - de Sanjose, Silvia
PY  - 2012
TI  - Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph
JF  - Journal of cancer research and clinical oncology
VL  - 138
IS  - 12
SP  - 1993-2001
EP  - 1993-2001
PB  - Springer-Verlag
SN  - 01715216
KW  - Chronic lymphocytic leukaemia
KW  - Diffuse large B-cell lymphoma
KW  - Follicular lymphoma
KW  - Multiple myeloma
KW  - NHL
KW  - B-NHL
KW  - T-cell lymphoma
N2  - Background We have recently reported from Epilymph, a multicentre case-control study of lymphoma conducted in six European countries, a significant association between NHL and self-reported history of past or present HBV infection based on questionnaire data from face-to-face interviews. Methods To corroborate this observation, we used the data and blood specimen from Epilymph to investigate the associations between serological indicators of HBV infection with risk of Hodgkin lymphoma, non-Hodgkin lymphoma (NHL) and specific lymphoma entities. For 1,518 cases and 1,496 controls with sufficient amount of serum or plasma, we tested HBs-antigen, anti-HBc and anti-HBs to distinguish between current or past infection and immunity by vaccination. Statistical analysis was carried out with unconditional logistic regression. Results We found a positive association of a past HBV infection with multiple myeloma (MM, OR = 1.97, 95 % CL = 1.16-3.37). Non-significant associations were found between past HBV infection and B-cell chronic lymphocytic leukaemia (B-CLL, OR = 1.33, 95 % CL = 0.82-2.16) and T-cell NHL (OR = 1.59, 95 % CL = 0.65-3.90), as well as between current HBV infection and NHL (OR = 1.49, 95 % CL = 0.65-3.41), B-NHL (OR = 1.58, 95 % CL = 0.69-3.64) and diffuse large B-cell lymphoma (DLBCL, OR = 1.50, 95 % CL = 0.47-4.82). Subjects having self-reported HBV infection were serological positive in 75 % of cases and 80 % of controls. For vaccination, the corresponding figures were 49 and 54 %, respectively. Conclusion The present results support previous reports of an association between a history of HBV infection with an elevated lymphoma risk and add multiple myeloma to the list of potentially virus-associated lymphoma entities.
ER  -

BECKER, Nikolaus; Paul SCHNITZLER; Paolo BOFFETTA; Paul BRENNAN; Lenka FORETOVÁ; Marc MAYNADIE; Alexandra NIETERS; Anthony STAINES; Yolanda BENAVENTE; Pierluigi COCCO a Silvia DE SANJOSE. Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph. \textit{Journal of cancer research and clinical oncology}. Germany: Springer-Verlag, 2012, roč.~138, č.~12, s.~1993-2001. ISSN~0171-5216. Dostupné z: https://doi.org/10.1007/s00432-012-1279-y.

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