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@article{1089116,
author = {Costas, Laura and Casabonne, Delphine and Benavente, Yolanda and Becker, Nikolaus and Boffetta, Paolo and Brennan, Paul and Cocco, Pierluigi and Foretová, Lenka and Maynadie, Marc and Staines, Anthony and Kane, Eleanor and Nieters, Alexandra and de Sanjose, Silvia},
article_location = {DORDRECHT},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s10552-011-9869-6},
keywords = {Lymphoma; Non-Hodgkin; Hodgkin; Reproductive factors; Hormonal Factors; Pregnancy; Parity; Contraception},
language = {eng},
issn = {0957-5243},
journal = {CANCER CAUSES & CONTROL},
title = {Reproductive factors and lymphoid neoplasms in Europe: findings from the EpiLymph case-control study},
volume = {23},
year = {2012}
}
TY - JOUR
ID - 1089116
AU - Costas, Laura - Casabonne, Delphine - Benavente, Yolanda - Becker, Nikolaus - Boffetta, Paolo - Brennan, Paul - Cocco, Pierluigi - Foretová, Lenka - Maynadie, Marc - Staines, Anthony - Kane, Eleanor - Nieters, Alexandra - de Sanjose, Silvia
PY - 2012
TI - Reproductive factors and lymphoid neoplasms in Europe: findings from the EpiLymph case-control study
JF - CANCER CAUSES & CONTROL
VL - 23
IS - 1
SP - 195-206
EP - 195-206
PB - SPRINGER
SN - 09575243
KW - Lymphoma
KW - Non-Hodgkin
KW - Hodgkin
KW - Reproductive factors
KW - Hormonal Factors
KW - Pregnancy
KW - Parity
KW - Contraception
N2 - The study of lymphomagenesis has rarely focused on hormonal factors. Higher incidence rates are observed for many lymphoma subtypes in men compared with women suggesting an underlying association. Our goal was to investigate the association between reproductive factors and lymphomas. The Epilymph study is a multicenter case-control study carried out in six European countries from 1998 to 2004. Female cases of mature T-cell neoplasms (n = 52), Hodgkin lymphoma (n = 147), and mature B-cell neoplasms (n = 795), including its common subtypes, and their respective controls (n = 1,141) frequency matched by age, gender, and center were considered. An odds reduction of 29% (95% CI -46 to -6%) was observed for mature T-cell neoplasms for each child increase among parous women and of 13% (95% CI -19 to -7%) for mature B-cell neoplasms; while no association was observed for Hodgkin lymphoma. By B-cell neoplasm subtypes, these associations were found for chronic lymphocytic leukemia/small lymphocytic lymphoma (-21%, 95% CI -31 to -9%) and diffuse large B-cell lymphoma (DLBCL; -14%; 95% CI -23 to -3%). Overall, no associations were observed with age at first and last pregnancy, and ever use of hormonal contraceptives and lymphoma. Higher odds ratios for a short-term use of hormonal contraceptives (< 5 years), but not for a long-term use, were observed for mature B-cell neoplasms, DLBCL, and follicular lymphoma compared with never use. These data support the hypothesis that increased parity confers a protective effect against lymphoma. Less clearly, our results also indicate that hormonal contraceptives could play a role.
ER -
COSTAS, Laura, Delphine CASABONNE, Yolanda BENAVENTE, Nikolaus BECKER, Paolo BOFFETTA, Paul BRENNAN, Pierluigi COCCO, Lenka FORETOVÁ, Marc MAYNADIE, Anthony STAINES, Eleanor KANE, Alexandra NIETERS a Silvia DE SANJOSE. Reproductive factors and lymphoid neoplasms in Europe: findings from the EpiLymph case-control study. \textit{CANCER CAUSES \&{}amp; CONTROL}. DORDRECHT: SPRINGER, 2012, roč.~23, č.~1, s.~195-206. ISSN~0957-5243. Dostupné z: https://dx.doi.org/10.1007/s10552-011-9869-6.
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