PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin
lymphoma: results from the InterLymph consortium

J 2012

PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

NIETERS, Alexandra; Lucia CONDE; Susan L SLAGER; Angela BROOKS-WILSON; Lindsay MORTON et al.

Základní údaje

Originální název

PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Autoři

NIETERS, Alexandra; Lucia CONDE; Susan L SLAGER; Angela BROOKS-WILSON; Lindsay MORTON; Danica R. SKIBOLA; Anne J. NOVAK; Jacques RIBY; Stephen M. ANSELL; Eran HALPERIN; Tait D. SHANAFELT; Luz AGANA; Alice H. WANG; Anneclaire J. DE ROOS; Richard K. SEVERSON; Wendy COZEN; John SPINELLI; Katja BUTTERBACH; Nikolaus BECKER; Silvia DE SANJOSE; Yolanda BENAVENTE; Pierluigi COCCO; Anthony STAINES; Marc MAYNADIE; Lenka FORETOVÁ; Paolo BOFFETTA; Paul BRENNAN; Qing LAN; Yawei ZHANG; Tongzhang ZHENG; Mark PURDUE; Bruce ARMSTRONG; Anne KRICKER; Claire M. VAJDIC; Andrew GRULICH; Martyn T. SMITH; Paige M. BRACCI; Stephen J. CHANOCK; Patricia HARTGE; James R. CERHAN; Sophia S. WANG; Nathaniel ROTHMAN a Christine F. SKIBOLA

Vydání

Blood, Washington DC, USA, American Society of Hematology, 2012, 0006-4971

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 9.060

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1182/blood-2012-05-427989

UT WoS

000313113300029

Klíčová slova anglicky

GENOME-WIDE ASSOCIATION; RHEUMATOID-ARTHRITIS; FOLLICULAR LYMPHOMA; GERMLINE VARIATION; SUSCEPTIBILITY; TNF; POLYMORPHISMS; NEOPLASMS; APOPTOSIS; LEUKEMIA

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2014 14:18, Soňa Böhmová

Anotace

V originále

Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11 gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, P random = 2.21 x 10(-11)), with similar risk estimates for common B-cell subtypes. PRRC2A rs3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, P random = 1.07 x 10(-9)) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes. (Blood. 2012; 120(23):4645-4648)

Citovat

@article{1089626,
   author = {Nieters, Alexandra and Conde, Lucia and Slager, Susan L and BrooksandWilson, Angela and Morton, Lindsay and Skibola, Danica R. and Novak, Anne J. and Riby, Jacques and Ansell, Stephen M. and Halperin, Eran and Shanafelt, Tait D. and Agana, Luz and Wang, Alice H. and De Roos, Anneclaire J. and Severson, Richard K. and Cozen, Wendy and Spinelli, John and Butterbach, Katja and Becker, Nikolaus and de Sanjose, Silvia and Benavente, Yolanda and Cocco, Pierluigi and Staines, Anthony and Maynadie, Marc and Foretová, Lenka and Boffetta, Paolo and Brennan, Paul and Lan, Qing and Zhang, Yawei and Zheng, Tongzhang and Purdue, Mark and Armstrong, Bruce and Kricker, Anne and Vajdic, Claire M. and Grulich, Andrew and Smith, Martyn T. and Bracci, Paige M. and Chanock, Stephen J. and Hartge, Patricia and Cerhan, James R. and Wang, Sophia S. and Rothman, Nathaniel and Skibola, Christine F.},
   article_location = {Washington DC, USA},
   article_number = {23},
   doi = {https://doi.org/10.1182/blood-2012-05-427989},
   keywords = {GENOME-WIDE ASSOCIATION; RHEUMATOID-ARTHRITIS; FOLLICULAR LYMPHOMA; GERMLINE VARIATION; SUSCEPTIBILITY; TNF; POLYMORPHISMS; NEOPLASMS; APOPTOSIS; LEUKEMIA},
   language = {eng},
   issn = {0006-4971},
   journal = {Blood},
   title = {PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium},
   volume = {120},
   year = {2012}
}

TY  - JOUR
ID  - 1089626
AU  - Nieters, Alexandra - Conde, Lucia - Slager, Susan L - Brooks-Wilson, Angela - Morton, Lindsay - Skibola, Danica R. - Novak, Anne J. - Riby, Jacques - Ansell, Stephen M. - Halperin, Eran - Shanafelt, Tait D. - Agana, Luz - Wang, Alice H. - De Roos, Anneclaire J. - Severson, Richard K. - Cozen, Wendy - Spinelli, John - Butterbach, Katja - Becker, Nikolaus - de Sanjose, Silvia - Benavente, Yolanda - Cocco, Pierluigi - Staines, Anthony - Maynadie, Marc - Foretová, Lenka - Boffetta, Paolo - Brennan, Paul - Lan, Qing - Zhang, Yawei - Zheng, Tongzhang - Purdue, Mark - Armstrong, Bruce - Kricker, Anne - Vajdic, Claire M. - Grulich, Andrew - Smith, Martyn T. - Bracci, Paige M. - Chanock, Stephen J. - Hartge, Patricia - Cerhan, James R. - Wang, Sophia S. - Rothman, Nathaniel - Skibola, Christine F.
PY  - 2012
TI  - PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium
JF  - Blood
VL  - 120
IS  - 23
SP  - 4645-4648
EP  - 4645-4648
PB  - American Society of Hematology
SN  - 00064971
KW  - GENOME-WIDE ASSOCIATION
KW  - RHEUMATOID-ARTHRITIS
KW  - FOLLICULAR LYMPHOMA
KW  - GERMLINE VARIATION
KW  - SUSCEPTIBILITY
KW  - TNF
KW  - POLYMORPHISMS
KW  - NEOPLASMS
KW  - APOPTOSIS
KW  - LEUKEMIA
N2  - Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11 gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, P random = 2.21 x 10(-11)), with similar risk estimates for common B-cell subtypes. PRRC2A rs3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, P random = 1.07 x 10(-9)) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes. (Blood. 2012; 120(23):4645-4648)
ER  -

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