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@article{1089632,
author = {´t Mannetje, Andrea and Brennan, Paul and Zaridze, David and SzeszeniaandDabrowska, Neonila and Rudnai, Peter and Lissowska, Jolanta and Fabianova, Eleonora and Cassidy, Adrian and Mates, Dana and Bencko, Vladimir and Foretová, Lenka and Janout, Vladimir and Fevotte, Joelle and Fletcher, Tony and Boffetta, Paolo},
article_location = {USA},
article_number = {7},
doi = {http://dx.doi.org/10.1093/aje/kwr358},
keywords = {case-control studies; confounding factors (epidemiology); lung neoplasms; metals; welding},
language = {eng},
issn = {0002-9262},
journal = {American journal of epidemiology},
title = {Welding and Lung Cancer in Central and Eastern Europe and the United Kingdom},
volume = {175},
year = {2012}
}
TY - JOUR
ID - 1089632
AU - ´t Mannetje, Andrea - Brennan, Paul - Zaridze, David - Szeszenia-Dabrowska, Neonila - Rudnai, Peter - Lissowska, Jolanta - Fabianova, Eleonora - Cassidy, Adrian - Mates, Dana - Bencko, Vladimir - Foretová, Lenka - Janout, Vladimir - Fevotte, Joelle - Fletcher, Tony - Boffetta, Paolo
PY - 2012
TI - Welding and Lung Cancer in Central and Eastern Europe and the United Kingdom
JF - American journal of epidemiology
VL - 175
IS - 7
SP - 706-714
EP - 706-714
PB - Oxford Univerity Press
SN - 00029262
KW - case-control studies
KW - confounding factors (epidemiology)
KW - lung neoplasms
KW - metals
KW - welding
N2 - Occupation as a welder has been associated with a 25%-40% increase in lung cancer risk. This study aims to elucidate to what extent confounding by smoking and asbestos drives this association and to evaluate the role of welding-related exposures such as chromium. The study included 2,197 male incident lung cancer cases and 2,295 controls from Romania, Hungary, Poland, Russia, Slovakia, the Czech Republic, and the United Kingdom from 1998 to 2001. Information on risk factors was collected through face-to-face interviews. Experts assessed exposure to 70 agents, and risk estimates were adjusted for smoking and occupational exposures. Occupation as a welder/flame cutter (prevalence controls: 3.7%) was associated with an odds ratio of 1.36 (95% confidence interval (CI): 1.00, 1.86) after adjustment for smoking and occupational exposures including asbestos. An odds ratio of 1.18 (95% CI: 1.01, 1.38) was found for welding fumes (prevalence controls: 22.8%), increasing to 1.38 for more than 25 exposure years (95% CI: 1.09, 1.75). A duration-response association was also observed for mild steel welding without chromium exposure. In this population, occupational exposure to welding fumes accounted for approximately 4% of lung cancer cases, to which both stainless and mild steel welding contributed equally. Given that welding remains a common task for many workers, exposure to welding fumes represents an important risk factor for lung cancer.
ER -
´T MANNETJE, Andrea, Paul BRENNAN, David ZARIDZE, Neonila SZESZENIA-DABROWSKA, Peter RUDNAI, Jolanta LISSOWSKA, Eleonora FABIANOVA, Adrian CASSIDY, Dana MATES, Vladimir BENCKO, Lenka FORETOVÁ, Vladimir JANOUT, Joelle FEVOTTE, Tony FLETCHER a Paolo BOFFETTA. Welding and Lung Cancer in Central and Eastern Europe and the United Kingdom. \textit{American journal of epidemiology}. USA: Oxford Univerity Press, 2012, roč.~175, č.~7, s.~706-714. ISSN~0002-9262. Dostupné z: https://dx.doi.org/10.1093/aje/kwr358.
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