Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
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TIMOFEEVA, Maria N.; Rayjean J. HUNG; Thorunn RAFNAR; David C. CHRISTIANI; John K. FIELD; Heike BICKEBOELLER; Angela RISCH; James D. MCKAY; Yufei WANG; Juncheng DAI; Valerie GABORIEAU; John MCLAUGHLIN; Darren BRENNER; Steven A. NAROD; Neil E. CAPORASO; Demetrius ALBANES; Michael THUN; Timothy EISEN; H. Erich WICHMANN; Albert ROSENBERGER; Younghun HAN; Wei CHEN; Dakai ZHU; Margaret SPITZ; Xifeng WU; Mala PANDE; Yang ZHAO; David ZARIDZE; Neonilia SZESZENIA-DABROWSKA; Jolanta LISSOWSKA; Peter RUDNAI; Eleonora FABIANOVÁ; Dana MATES; Vladimir BENCKO; Lenka FORETOVÁ; Vladimir JANOUT; Hans E. KROKAN; Maiken Elvestad GABRIELSEN; Frank SKORPEN; Lars VATTEN; Inger NJOLSTAD; Chu CHEN; Gary GOODMAN; Mark LATHROP; Simone BENHAMOU; Tonu VOODER; Kristjan VAELK; Mari NELIS; Andres METSPALU; Olaide RAJI; Ying CHEN; John GOSNEY; Triantafillos LILOGLOU; Thomas MULEY; Hendrik DIENEMANN; Gudmar THORLEIFSSON; Hongbing SHEN; Kari STEFANSSON; Paul BRENNAN; Christopher I. AMOS; Richard HOULSTON a Maria Teresa LANDI
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Human molecular genetics, OXFORD, OXFORD UNIV PRESS, 2012, 0964-6906
Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p216p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)) which was replicated in a series of 5415 Han Chinese (P 0.03; combined analysis, P 2.3 10(8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer.
TIMOFEEVA, Maria N.; Rayjean J. HUNG; Thorunn RAFNAR; David C. CHRISTIANI; John K. FIELD; Heike BICKEBOELLER; Angela RISCH; James D. MCKAY; Yufei WANG; Juncheng DAI; Valerie GABORIEAU; John MCLAUGHLIN; Darren BRENNER; Steven A. NAROD; Neil E. CAPORASO; Demetrius ALBANES; Michael THUN; Timothy EISEN; H. Erich WICHMANN; Albert ROSENBERGER; Younghun HAN; Wei CHEN; Dakai ZHU; Margaret SPITZ; Xifeng WU; Mala PANDE; Yang ZHAO; David ZARIDZE; Neonilia SZESZENIA-DABROWSKA; Jolanta LISSOWSKA; Peter RUDNAI; Eleonora FABIANOVÁ; Dana MATES; Vladimir BENCKO; Lenka FORETOVÁ; Vladimir JANOUT; Hans E. KROKAN; Maiken Elvestad GABRIELSEN; Frank SKORPEN; Lars VATTEN; Inger NJOLSTAD; Chu CHEN; Gary GOODMAN; Mark LATHROP; Simone BENHAMOU; Tonu VOODER; Kristjan VAELK; Mari NELIS; Andres METSPALU; Olaide RAJI; Ying CHEN; John GOSNEY; Triantafillos LILOGLOU; Thomas MULEY; Hendrik DIENEMANN; Gudmar THORLEIFSSON; Hongbing SHEN; Kari STEFANSSON; Paul BRENNAN; Christopher I. AMOS; Richard HOULSTON a Maria Teresa LANDI. Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Human molecular genetics. OXFORD: OXFORD UNIV PRESS, 2012, roč. 21, č. 22, s. 4980-4995. ISSN 0964-6906. Dostupné z: https://doi.org/10.1093/hmg/dds334.
@article{1089648, author = {Timofeeva, Maria N. and Hung, Rayjean J. and Rafnar, Thorunn and Christiani, David C. and Field, John K. and Bickeboeller, Heike and Risch, Angela and McKay, James D. and Wang, Yufei and Dai, Juncheng and Gaborieau, Valerie and McLaughlin, John and Brenner, Darren and Narod, Steven A. and Caporaso, Neil E. and Albanes, Demetrius and Thun, Michael and Eisen, Timothy and Wichmann, H. Erich and Rosenberger, Albert and Han, Younghun and Chen, Wei and Zhu, Dakai and Spitz, Margaret and Wu, Xifeng and Pande, Mala and Zhao, Yang and Zaridze, David and SzeszeniaandDabrowska, Neonilia and Lissowska, Jolanta and Rudnai, Peter and Fabianová, Eleonora and Mates, Dana and Bencko, Vladimir and Foretová, Lenka and Janout, Vladimir and Krokan, Hans E. and Gabrielsen, Maiken Elvestad and Skorpen, Frank and Vatten, Lars and Njolstad, Inger and Chen, Chu and Goodman, Gary and Lathrop, Mark and Benhamou, Simone and Vooder, Tonu and Vaelk, Kristjan and Nelis, Mari and Metspalu, Andres and Raji, Olaide and Chen, Ying and Gosney, John and Liloglou, Triantafillos and Muley, Thomas and Dienemann, Hendrik and Thorleifsson, Gudmar and Shen, Hongbing and Stefansson, Kari and Brennan, Paul and Amos, Christopher I. and Houlston, Richard and Landi, Maria Teresa}, article_location = {OXFORD}, article_number = {22}, doi = {https://doi.org/10.1093/hmg/dds334}, keywords = {GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; DNA DOUBLE-STRAND; SUSCEPTIBILITY LOCI; LARGE-SCALE; JAPANESE POPULATION; GENOTYPE IMPUTATION; NICOTINE DEPENDENCE; IN-VIVO; VARIANTS}, language = {eng}, issn = {0964-6906}, journal = {Human molecular genetics}, title = {Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls}, volume = {21}, year = {2012} }
TY - JOUR ID - 1089648 AU - Timofeeva, Maria N. - Hung, Rayjean J. - Rafnar, Thorunn - Christiani, David C. - Field, John K. - Bickeboeller, Heike - Risch, Angela - McKay, James D. - Wang, Yufei - Dai, Juncheng - Gaborieau, Valerie - McLaughlin, John - Brenner, Darren - Narod, Steven A. - Caporaso, Neil E. - Albanes, Demetrius - Thun, Michael - Eisen, Timothy - Wichmann, H. Erich - Rosenberger, Albert - Han, Younghun - Chen, Wei - Zhu, Dakai - Spitz, Margaret - Wu, Xifeng - Pande, Mala - Zhao, Yang - Zaridze, David - Szeszenia-Dabrowska, Neonilia - Lissowska, Jolanta - Rudnai, Peter - Fabianová, Eleonora - Mates, Dana - Bencko, Vladimir - Foretová, Lenka - Janout, Vladimir - Krokan, Hans E. - Gabrielsen, Maiken Elvestad - Skorpen, Frank - Vatten, Lars - Njolstad, Inger - Chen, Chu - Goodman, Gary - Lathrop, Mark - Benhamou, Simone - Vooder, Tonu - Vaelk, Kristjan - Nelis, Mari - Metspalu, Andres - Raji, Olaide - Chen, Ying - Gosney, John - Liloglou, Triantafillos - Muley, Thomas - Dienemann, Hendrik - Thorleifsson, Gudmar - Shen, Hongbing - Stefansson, Kari - Brennan, Paul - Amos, Christopher I. - Houlston, Richard - Landi, Maria Teresa PY - 2012 TI - Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls JF - Human molecular genetics VL - 21 IS - 22 SP - 4980-4995 EP - 4980-4995 PB - OXFORD UNIV PRESS SN - 09646906 KW - GENOME-WIDE ASSOCIATION KW - CORONARY-ARTERY-DISEASE KW - DNA DOUBLE-STRAND KW - SUSCEPTIBILITY LOCI KW - LARGE-SCALE KW - JAPANESE POPULATION KW - GENOTYPE IMPUTATION KW - NICOTINE DEPENDENCE KW - IN-VIVO KW - VARIANTS N2 - Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p216p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)) which was replicated in a series of 5415 Han Chinese (P 0.03; combined analysis, P 2.3 10(8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer. ER -
TIMOFEEVA, Maria N.; Rayjean J. HUNG; Thorunn RAFNAR; David C. CHRISTIANI; John K. FIELD; Heike BICKEBOELLER; Angela RISCH; James D. MCKAY; Yufei WANG; Juncheng DAI; Valerie GABORIEAU; John MCLAUGHLIN; Darren BRENNER; Steven A. NAROD; Neil E. CAPORASO; Demetrius ALBANES; Michael THUN; Timothy EISEN; H. Erich WICHMANN; Albert ROSENBERGER; Younghun HAN; Wei CHEN; Dakai ZHU; Margaret SPITZ; Xifeng WU; Mala PANDE; Yang ZHAO; David ZARIDZE; Neonilia SZESZENIA-DABROWSKA; Jolanta LISSOWSKA; Peter RUDNAI; Eleonora FABIANOVÁ; Dana MATES; Vladimir BENCKO; Lenka FORETOVÁ; Vladimir JANOUT; Hans E. KROKAN; Maiken Elvestad GABRIELSEN; Frank SKORPEN; Lars VATTEN; Inger NJOLSTAD; Chu CHEN; Gary GOODMAN; Mark LATHROP; Simone BENHAMOU; Tonu VOODER; Kristjan VAELK; Mari NELIS; Andres METSPALU; Olaide RAJI; Ying CHEN; John GOSNEY; Triantafillos LILOGLOU; Thomas MULEY; Hendrik DIENEMANN; Gudmar THORLEIFSSON; Hongbing SHEN; Kari STEFANSSON; Paul BRENNAN; Christopher I. AMOS; Richard HOULSTON a Maria Teresa LANDI. Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. \textit{Human molecular genetics}. OXFORD: OXFORD UNIV PRESS, 2012, roč.~21, č.~22, s.~4980-4995. ISSN~0964-6906. Dostupné z: https://doi.org/10.1093/hmg/dds334.