Impairment of Brain Vessels May Contribute to Mortality in
Patients With Parkinson's Disease

J 2012

Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease

REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ et. al.

Základní údaje

Originální název

Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease

Autoři

REKTOR, Ivan (203 Česká republika, garant, domácí), David GOLDEMUND (203 Česká republika, domácí), Petr BEDNAŘÍK (203 Česká republika, domácí), Kateřina SHEARDOVÁ (203 Česká republika, domácí), Zuzana MICHÁLKOVÁ (203 Česká republika, domácí), Sabina TELECKÁ (203 Česká republika, domácí), Michal DUFEK (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, domácí)

Vydání

Movement Disorders, Hoboken, USA, WILEY-BLACKWELL, 2012, 0885-3185

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.558

Kód RIV

RIV/00216224:14740/12:00064335

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/mds.25066

UT WoS

000307387400030

Klíčová slova anglicky

cerebrovascular disease; Parkinson's disease; MRI; ultrasound

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 3. 2013 07:43, Olga Křížová

Anotace

V originále

Background: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. Results: US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score). Conclusions: This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. (C) 2012 Movement Disorder Society

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ, Sabina TELECKÁ, Michal DUFEK a Irena REKTOROVÁ. Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. Movement Disorders. Hoboken, USA: WILEY-BLACKWELL, 2012, roč. 27, č. 9, s. 1168-1172. ISSN 0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.25066.

@article{1090829,
   author = {Rektor, Ivan and Goldemund, David and Bednařík, Petr and Sheardová, Kateřina and Michálková, Zuzana and Telecká, Sabina and Dufek, Michal and Rektorová, Irena},
   article_location = {Hoboken, USA},
   article_number = {9},
   doi = {http://dx.doi.org/10.1002/mds.25066},
   keywords = {cerebrovascular disease; Parkinson's disease; MRI; ultrasound},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22692677},
   volume = {27},
   year = {2012}
}

TY  - JOUR
ID  - 1090829
AU  - Rektor, Ivan - Goldemund, David - Bednařík, Petr - Sheardová, Kateřina - Michálková, Zuzana - Telecká, Sabina - Dufek, Michal - Rektorová, Irena
PY  - 2012
TI  - Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease
JF  - Movement Disorders
VL  - 27
IS  - 9
SP  - 1168-1172
EP  - 1168-1172
PB  - WILEY-BLACKWELL
SN  - 08853185
KW  - cerebrovascular disease
KW  - Parkinson's disease
KW  - MRI
KW  - ultrasound
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22692677
L2  - http://www.ncbi.nlm.nih.gov/pubmed/22692677
N2  - Background: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. Results: US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score). Conclusions: This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. (C) 2012 Movement Disorder Society
ER  -

REKTOR, Ivan, David GOLDEMUND, Petr BEDNAŘÍK, Kateřina SHEARDOVÁ, Zuzana MICHÁLKOVÁ, Sabina TELECKÁ, Michal DUFEK a Irena REKTOROVÁ. Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. \textit{Movement Disorders}. Hoboken, USA: WILEY-BLACKWELL, 2012, roč.~27, č.~9, s.~1168-1172. ISSN~0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.25066.

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