Evaluation of the Efficacy of Additional Measures Introduced
for the Protection of Healthcare Personnel Handling
Antineoplastic Drugs

J 2013

Evaluation of the Efficacy of Additional Measures Introduced for the Protection of Healthcare Personnel Handling Antineoplastic Drugs

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER et. al.

Základní údaje

Originální název

Evaluation of the Efficacy of Additional Measures Introduced for the Protection of Healthcare Personnel Handling Antineoplastic Drugs

Autoři

ODRÁŠKA, Pavel (203 Česká republika, garant), Lenka DOLEZALOVA (203 Česká republika), Jan KUTA (203 Česká republika, domácí), Michal ORAVEC (203 Česká republika, domácí), Pavel PILER (203 Česká republika, domácí) a Luděk BLÁHA (203 Česká republika, domácí)

Vydání

ANNALS OF OCCUPATIONAL HYGIENE, OXFORD, OXFORD UNIV PRESS, 2013, 0003-4878

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.068

Kód RIV

RIV/00216224:14310/13:00067961

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1093/annhyg/mes057

UT WoS

000315158600008

Klíčová slova anglicky

chemical analysis; cytotoxic drugs; hazardous pharmaceuticals; occupational exposure; safety engineering

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 4. 2014 20:35, prof. RNDr. Luděk Bláha, Ph.D.

Anotace

V originále

Antineoplastic drugs are considered as a potential health risk to healthcare personnel, due to their adverse effects. The objective of the study was to compare the surface contamination level of the conventional preparation room and outpatient clinic before and after the implementation of a set of additional protective measures. To determine the surface contamination level with antineoplastic drugs, cyclophosphamide and platinum were determined in wipe samples with high performance liquid chromatography with tandem mass spectrometry and inductively coupled plasma mass spectrometry.In the preparation room, depending on the sampling spot and analyte, median concentrations ranged from 5 to 267 pg cm(2) and from 2 to 368 pg cm(2) before and after implementation of the measures, respectively. In the outpatient clinic, median concentrations ranged from 5 to 5310 pg cm(2) and from < 0.2 to 574 pg cm(2) before and after implementation of the measures, respectively. Depending on the sampling spot, median contamination of the outpatient clinic with cyclophosphamide and platinum was reduced by 5799% and 6198%, respectively.The measures implemented in the outpatient clinic were shown to reduce workplace contamination effectively. Therefore, they can be recommended also for other workplaces where antineoplastic drugs are administered. In contrast, measures implemented in the preparation room, where relatively strict regulations had already been adopted before the study, were less effective. To decrease the actual contamination of the preparation room, other protective measures (e.g. closed-system transfer devices) should be considered.

Návaznosti

ED0001/01/01, projekt VaV

Název: CETOCOEN

EE2.3.20.0053, projekt VaV

Název: Podpora odborníků a mezinárodního networkingu v oblastech environmentálního výzkumu v ČR

LM2011028, projekt VaV

Název: RECETOX ? Národní infrastruktura pro výzkum toxických látek v prostředí

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX Národní infrastruktura pro výzkum toxických látek v prostředí

Citovat

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER a Luděk BLÁHA. Evaluation of the Efficacy of Additional Measures Introduced for the Protection of Healthcare Personnel Handling Antineoplastic Drugs. ANNALS OF OCCUPATIONAL HYGIENE. OXFORD: OXFORD UNIV PRESS, 2013, roč. 57, č. 2, s. 240-250. ISSN 0003-4878. Dostupné z: https://dx.doi.org/10.1093/annhyg/mes057.

@article{1093228,
   author = {Odráška, Pavel and Dolezalova, Lenka and Kuta, Jan and Oravec, Michal and Piler, Pavel and Bláha, Luděk},
   article_location = {OXFORD},
   article_number = {2},
   doi = {http://dx.doi.org/10.1093/annhyg/mes057},
   keywords = {chemical analysis; cytotoxic drugs; hazardous pharmaceuticals; occupational exposure; safety engineering},
   language = {eng},
   issn = {0003-4878},
   journal = {ANNALS OF OCCUPATIONAL HYGIENE},
   title = {Evaluation of the Efficacy of Additional Measures Introduced for the Protection of Healthcare Personnel Handling Antineoplastic Drugs},
   volume = {57},
   year = {2013}
}

TY  - JOUR
ID  - 1093228
AU  - Odráška, Pavel - Dolezalova, Lenka - Kuta, Jan - Oravec, Michal - Piler, Pavel - Bláha, Luděk
PY  - 2013
TI  - Evaluation of the Efficacy of Additional Measures Introduced for the Protection of Healthcare Personnel Handling Antineoplastic Drugs
JF  - ANNALS OF OCCUPATIONAL HYGIENE
VL  - 57
IS  - 2
SP  - 240-250
EP  - 240-250
PB  - OXFORD UNIV PRESS
SN  - 00034878
KW  - chemical analysis
KW  - cytotoxic drugs
KW  - hazardous pharmaceuticals
KW  - occupational exposure
KW  - safety engineering
N2  - Antineoplastic drugs are considered as a potential health risk to healthcare personnel, due to their adverse effects. The objective of the study was to compare the surface contamination level of the conventional preparation room and outpatient clinic before and after the implementation of a set of additional protective measures. To determine the surface contamination level with antineoplastic drugs, cyclophosphamide and platinum were determined in wipe samples with high performance liquid chromatography with tandem mass spectrometry and inductively coupled plasma mass spectrometry.In the preparation room, depending on the sampling spot and analyte, median concentrations ranged from 5 to 267 pg cm(2) and from 2 to 368 pg cm(2) before and after implementation of the measures, respectively. In the outpatient clinic, median concentrations ranged from 5 to 5310 pg cm(2) and from < 0.2 to 574 pg cm(2) before and after implementation of the measures, respectively. Depending on the sampling spot, median contamination of the outpatient clinic with cyclophosphamide and platinum was reduced by 5799% and 6198%, respectively.The measures implemented in the outpatient clinic were shown to reduce workplace contamination effectively. Therefore, they can be recommended also for other workplaces where antineoplastic drugs are administered. In contrast, measures implemented in the preparation room, where relatively strict regulations had already been adopted before the study, were less effective. To decrease the actual contamination of the preparation room, other protective measures (e.g. closed-system transfer devices) should be considered.
ER  -

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER a Luděk BLÁHA. Evaluation of the Efficacy of Additional Measures Introduced for the Protection of Healthcare Personnel Handling Antineoplastic Drugs. \textit{ANNALS OF OCCUPATIONAL HYGIENE}. OXFORD: OXFORD UNIV PRESS, 2013, roč.~57, č.~2, s.~240-250. ISSN~0003-4878. Dostupné z: https://dx.doi.org/10.1093/annhyg/mes057.

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