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@article{1093472,
author = {Nekrasov, M and Amrichová, Jana and Parker, BJ and Soboleva, TA and Jack, C and Williams, R and Huttley, GA and Tremethick, DJ},
article_location = {United States},
doi = {http://dx.doi.org/10.1038/nsmb.2424},
keywords = {histone, H2A.Z, cell cycle, promoter organisation, nucleosomes},
issn = {1545-9985},
journal = {NATURE STRUCTURAL & MOLECULAR BIOLOGY},
title = {Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics},
year = {2012}
}
TY - JOUR
ID - 1093472
AU - Nekrasov, M - Amrichová, Jana - Parker, BJ - Soboleva, TA - Jack, C - Williams, R - Huttley, GA - Tremethick, DJ
PY - 2012
TI - Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics
JF - NATURE STRUCTURAL & MOLECULAR BIOLOGY
SP - 1076-1083
EP - 1076-1083
PB - Nature Pub. Group,
SN - 15459985
KW - histone, H2A.Z, cell cycle, promoter organisation, nucleosomes
N2 - Although it has been clearly established that well-positioned histone H2A.Z-containing nucleosomes flank the nucleosome-depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here that in mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS becoming heterotypic (H2A.Z-H2A). To our surprise these nucleosomes remained heterotypic at M phase. At the TSS, we identified an unstable heterotypic histone H2A.Z-containing nucleosome in G1 phase that was lost after DNA replication. These dynamic changes at the TSS mirror a global expansion of the NDR at S and M phases, which, unexpectedly, is unrelated to transcriptional activity. Coincident with the loss of histone H2A.Z at promoters, histone H2A.Z is targeted to the centromere when mitosis begins.
ER -
NEKRASOV, M, Jana AMRICHOVÁ, BJ PARKER, TA SOBOLEVA, C JACK, R WILLIAMS, GA HUTTLEY and DJ TREMETHICK. Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics. \textit{NATURE STRUCTURAL \&{} MOLECULAR BIOLOGY}. United States: Nature Pub. Group,, 2012, p.~1076-1083. ISSN~1545-9985. Available from: https://dx.doi.org/10.1038/nsmb.2424.
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