| SROVNALOVÁ, Hana, Radek MAREČEK, Radka KUBÍKOVÁ a Irena REKTOROVÁ. The role of the right dorsolateral prefrontal cortex in the Tower of London task performance: repetitive transcranial magnetic stimulation study in patients with Parkinson's disease. Experimental Brain Research. NEW YORK: Springer Verlag, 2012, roč. 223, č. 2, s. 251-257. ISSN 0014-4819. Dostupné z: https://dx.doi.org/10.1007/s00221-012-3255-9. |
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@article{1094318,
author = {Srovnalová, Hana and Mareček, Radek and Kubíková, Radka and Rektorová, Irena},
article_location = {NEW YORK},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s00221-012-3255-9},
keywords = {Parkinson's disease; Repetitive transcranial magnetic stimulation; Tower of London task; Executive function; Dorsolateral prefrontal cortex},
language = {eng},
issn = {0014-4819},
journal = {Experimental Brain Research},
title = {The role of the right dorsolateral prefrontal cortex in the Tower of London task performance: repetitive transcranial magnetic stimulation study in patients with Parkinson's disease},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22975864},
volume = {223},
year = {2012}
}
TY - JOUR
ID - 1094318
AU - Srovnalová, Hana - Mareček, Radek - Kubíková, Radka - Rektorová, Irena
PY - 2012
TI - The role of the right dorsolateral prefrontal cortex in the Tower of London task performance: repetitive transcranial magnetic stimulation study in patients with Parkinson's disease
JF - Experimental Brain Research
VL - 223
IS - 2
SP - 251-257
EP - 251-257
PB - Springer Verlag
SN - 00144819
KW - Parkinson's disease
KW - Repetitive transcranial magnetic stimulation
KW - Tower of London task
KW - Executive function
KW - Dorsolateral prefrontal cortex
UR - http://www.ncbi.nlm.nih.gov/pubmed/22975864
L2 - http://www.ncbi.nlm.nih.gov/pubmed/22975864
N2 - We studied whether one session of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over either the right or left dorsolateral prefrontal cortex would induce any measurable changes in the Tower of London spatial planning task performance in patients with Parkinson's disease (PD). Ten patients with PD (with no dementia and/or depression) entered the randomized, sham-stimulation-controlled study with a crossover design. Active and placebo rTMS were applied over either the left or the right dorsolateral prefrontal cortex (in four separate sessions) in each patient. The order of sessions was randomized. The Tower of London task was performed prior to and immediately after each appropriate session. The "total problem-solving time" was our outcome measure. Only active rTMS of the right dorsolateral prefrontal cortex induced significant enhancement of the total problem-solving time, p = 0.038. Stimulation of the left prefrontal cortex or sham stimulations induced no significant effects. Only rTMS applied over the right dorsolateral prefrontal cortex induced positive changes in the spatial planning task performance in PD, which further supports the results of functional imaging studies indicating the causal engagement of the right-sided hemispheric structures in solving the task in this patient population.
ER -
SROVNALOVÁ, Hana, Radek MAREČEK, Radka KUBÍKOVÁ a Irena REKTOROVÁ. The role of the right dorsolateral prefrontal cortex in the Tower of London task performance: repetitive transcranial magnetic stimulation study in patients with Parkinson's disease. \textit{Experimental Brain Research}. NEW YORK: Springer Verlag, 2012, roč.~223, č.~2, s.~251-257. ISSN~0014-4819. Dostupné z: https://dx.doi.org/10.1007/s00221-012-3255-9.
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