Formation of Secretory Senescent Cells in Prostate Tumors: The
Role of Androgen Receptor Activity and Cell Cycle Regulation

C 2013

Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation

PERNICOVÁ, Zuzana; Petr VAŇHARA a Karel SOUČEK

Základní údaje

Originální název

Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation

Autoři

PERNICOVÁ, Zuzana; Petr VAŇHARA a Karel SOUČEK

Vydání

Dordrecht, Tumor Dormancy, Quiescence and Senescence, od s. 303-316, 14 s. Aging, Cancer, and Noncancer Pathologies, Vol. 1, 2013

Nakladatel

Springer Science+Business Media

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00068061

Organizační jednotka

Lékařská fakulta

ISBN

978-94-007-5957-2

DOI

https://doi.org/10.1007/978-94-007-5958-9_26

Klíčová slova anglicky

prostate cancer; senescence; neuroendocrine differentiation; senescence-associated secretory phenotype; androgen receptor; Skp2

Příznaky

Mezinárodní význam

Změněno: 28. 3. 2014 16:36, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

The induction of senescence in cancer cells is believed to be a potent mechanism of tumor suppression; however, senescent cells remain metabolically active and secrete a broad spectrum of factors, modulate the tissue microenvironment, and potentially promote tumorigenicity in neighboring malignant cells. Another important subpopulation of secretory cells modulating the prostate tissue microenvironment is represented by neuroendocrine cells. Interestingly, androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces both the emergence of neuroendocrine-like prostate cancer cells and the senescence-associated secretory phenotype in prostate cancer epithelial cells. The induction of the senescence-associated secretory phenotype by androgen depletion is tightly connected with the regulation of the cell cycle machinery through the downregulation of S-phase kinase-associated protein 2, whereas the emergence of neuroendocrine-like cancer cells (through the process of neuroendocrine differentiation) is under separate control. In this chapter, we summarize possible mechanisms and consequences of the formation of the aforementioned secretory phenotypes in prostate tumors and the role of the androgen receptor and cell cycle regulation in these processes.

Návaznosti

MSM0021622430, záměr

Název: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Citovat

PERNICOVÁ, Zuzana; Petr VAŇHARA a Karel SOUČEK. Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation. In Hayat, M.A. Tumor Dormancy, Quiescence and Senescence. Dordrecht: Springer Science+Business Media, 2013, s. 303-316. Aging, Cancer, and Noncancer Pathologies, Vol. 1. ISBN 978-94-007-5957-2. Dostupné z: https://doi.org/10.1007/978-94-007-5958-9_26.

@inbook{1095371,
   author = {Pernicová, Zuzana and Vaňhara, Petr and Souček, Karel},
   address = {Dordrecht},
   booktitle = {Tumor Dormancy, Quiescence and Senescence},
   doi = {https://doi.org/10.1007/978-94-007-5958-9_26},
   editor = {Hayat, M.A.},
   keywords = {prostate cancer; senescence; neuroendocrine differentiation; senescence-associated secretory phenotype; androgen receptor; Skp2},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Dordrecht},
   isbn = {978-94-007-5957-2},
   pages = {303-316},
   publisher = {Springer Science+Business Media},
   title = {Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation},
   url = {http://dx.doi.org/10.1007/978-94-007-5958-9_26},
   year = {2013}
}

TY  - CHAP
ID  - 1095371
AU  - Pernicová, Zuzana - Vaňhara, Petr - Souček, Karel
PY  - 2013
TI  - Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation
VL  - Aging, Cancer, and Noncancer Pathologies, Vol. 1
PB  - Springer Science+Business Media
CY  - Dordrecht
SN  - 9789400759572
KW  - prostate cancer
KW  - senescence
KW  - neuroendocrine differentiation
KW  - senescence-associated secretory phenotype
KW  - androgen receptor
KW  - Skp2
UR  - http://dx.doi.org/10.1007/978-94-007-5958-9_26
N2  - The induction of senescence in cancer cells is believed to be a potent mechanism of tumor suppression; however, senescent cells remain metabolically active and secrete a broad spectrum of factors, modulate the tissue microenvironment, and potentially promote tumorigenicity in neighboring malignant cells. Another important subpopulation of secretory cells modulating the prostate tissue microenvironment is represented by neuroendocrine cells. Interestingly, androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces both the emergence of neuroendocrine-like prostate cancer cells and the senescence-associated secretory phenotype in prostate cancer epithelial cells. The induction of the senescence-associated secretory phenotype by androgen depletion is tightly connected with the regulation of the cell cycle machinery through the downregulation of S-phase kinase-associated protein 2, whereas the emergence of neuroendocrine-like cancer cells (through the process of neuroendocrine differentiation) is under separate control. In this chapter, we summarize possible mechanisms and consequences of the formation of the aforementioned secretory phenotypes in prostate tumors and the role of the androgen receptor and cell cycle regulation in these processes.
ER  -

PERNICOVÁ, Zuzana; Petr VAŇHARA a Karel SOUČEK. Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation. In Hayat, M.A. \textit{Tumor Dormancy, Quiescence and Senescence}. Dordrecht: Springer Science+Business Media, 2013, s.~303-316. Aging, Cancer, and Noncancer Pathologies, Vol. 1. ISBN~978-94-007-5957-2. Dostupné z: https://doi.org/10.1007/978-94-007-5958-9\_{}26.

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