Preliminary evidence for association between schizophrenia and
polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and
SNAP-25 Genes

J 2013

Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes

LOCHMAN, Jan; Vladimir J BALCAR; Frantisek STASTNY a Omar ŠERÝ

Základní údaje

Originální název

Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes

Autoři

LOCHMAN, Jan; Vladimir J BALCAR; Frantisek STASTNY a Omar ŠERÝ

Vydání

Psychiatry Research, Elsevier Ireland, 2013, 0165-1781

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.682

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/13:00066087

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1016/j.psychres.2012.08.003

UT WoS

000315252500002

Klíčová slova anglicky

Schizophrenia; Adrenergic receptor; Dopamine receptor; Association

Štítky

AKR, rivok

Změněno: 8. 4. 2014 21:23, Ing. Andrea Mikešková

Anotace

V originále

The results of linkage and candidate gene association studies have led to a range of hypotheses about the pathogenesis of schizophrenia. We limited our study to polymorphisms in candidate genes involved in dopaminergic and noradrenergic systems, and in the 25 KDa synaptosomal-associated protein (SNAP-25) gene that is related to neurotransmitter exocytosis. Eight single nucleotide polymorphisms (SNPs) in regulating or coding regions of genes for the alpha-2A adrenergic receptor (ADRA2A), dopamine receptors D1 and D3 (DRD1 and DRD3), dopamine beta-hydroxylase (DBH) and SNAP-25 were genotyped in male patients with schizophrenia (n=192) and in healthy controls (n=213). These polymorphisms were previously associated with schizophrenia. The allelic association between schizophrenia and ADRA2A rs1800544 polymorphism, SNAP-25 rs1503112 polymorphism, and DRD3 rs6280 polymorphism was found in our study. However, only obseivations for rs1503112 survived correction for multiple testing. Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152). Our results are in agreement with the previously proposed role of DNA polymorphisms involved in dopaminergic, noradrenergic and synaptic functions in the pathogenesis of schizophrenia. Further relevant studies including larger sample size and more markers are needed to confirm our results. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Návaznosti

GP309/09/P361, projekt VaV

Název: Vztah interakce polymorfismů kandidátních genů k patogenezi schizofrenie

Investor: Grantová agentura ČR, Vztah interakce polymorfismů kandidátních genů k patogenezi schizofrenie

Citovat

LOCHMAN, Jan; Vladimir J BALCAR; Frantisek STASTNY a Omar ŠERÝ. Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes. Psychiatry Research. Elsevier Ireland, 2013, roč. 205, 1-2, s. 7-12. ISSN 0165-1781. Dostupné z: https://doi.org/10.1016/j.psychres.2012.08.003.

@article{1095375,
   author = {Lochman, Jan and Balcar, Vladimir J and Stastny, Frantisek and Šerý, Omar},
   article_number = {1-2},
   doi = {https://doi.org/10.1016/j.psychres.2012.08.003},
   keywords = {Schizophrenia; Adrenergic receptor; Dopamine receptor; Association},
   language = {eng},
   issn = {0165-1781},
   journal = {Psychiatry Research},
   title = {Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes},
   url = {http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=X1iieNO2dc74bDkDd56&page=1&doc=4},
   volume = {205},
   year = {2013}
}

TY  - JOUR
ID  - 1095375
AU  - Lochman, Jan - Balcar, Vladimir J - Stastny, Frantisek - Šerý, Omar
PY  - 2013
TI  - Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes
JF  - Psychiatry Research
VL  - 205
IS  - 1-2
SP  - 7-12
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PB  - Elsevier Ireland
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KW  - Schizophrenia
KW  - Adrenergic receptor
KW  - Dopamine receptor
KW  - Association
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N2  - The results of linkage and candidate gene association studies have led to a range of hypotheses about the pathogenesis of schizophrenia. We limited our study to polymorphisms in candidate genes involved in dopaminergic and noradrenergic systems, and in the 25 KDa synaptosomal-associated protein (SNAP-25) gene that is related to neurotransmitter exocytosis. Eight single nucleotide polymorphisms (SNPs) in regulating or coding regions of genes for the alpha-2A adrenergic receptor (ADRA2A), dopamine receptors D1 and D3 (DRD1 and DRD3), dopamine beta-hydroxylase (DBH) and SNAP-25 were genotyped in male patients with schizophrenia (n=192) and in healthy controls (n=213). These polymorphisms were previously associated with schizophrenia. The allelic association between schizophrenia and ADRA2A rs1800544 polymorphism, SNAP-25 rs1503112 polymorphism, and DRD3 rs6280 polymorphism was found in our study. However, only obseivations for rs1503112 survived correction for multiple testing. Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152). Our results are in agreement with the previously proposed role of DNA polymorphisms involved in dopaminergic, noradrenergic and synaptic functions in the pathogenesis of schizophrenia. Further relevant studies including larger sample size and more markers are needed to confirm our results. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
ER  -

LOCHMAN, Jan; Vladimir J BALCAR; Frantisek STASTNY a Omar ŠERÝ. Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes. \textit{Psychiatry Research}. Elsevier Ireland, 2013, roč.~205, 1-2, s.~7-12. ISSN~0165-1781. Dostupné z: https://doi.org/10.1016/j.psychres.2012.08.003.

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