| TESAŘOVÁ, Lenka, Stanislav STEJSKAL a Irena KRONTORÁD KOUTNÁ. Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives. CURRENT PHARMACEUTICAL DESIGN. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2014, roč. 20, č. 11, s. 1674-1686. ISSN 1381-6128. Dostupné z: https://dx.doi.org/10.2174/13816128113199990524. |
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@article{1095798,
author = {Tesařová, Lenka and Stejskal, Stanislav and Krontorád Koutná, Irena},
article_location = {SHARJAH},
article_number = {11},
doi = {http://dx.doi.org/10.2174/13816128113199990524},
keywords = {epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development},
language = {eng},
issn = {1381-6128},
journal = {CURRENT PHARMACEUTICAL DESIGN},
title = {Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives},
volume = {20},
year = {2014}
}
TY - JOUR
ID - 1095798
AU - Tesařová, Lenka - Stejskal, Stanislav - Krontorád Koutná, Irena
PY - 2014
TI - Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives
JF - CURRENT PHARMACEUTICAL DESIGN
VL - 20
IS - 11
SP - 1674-1686
EP - 1674-1686
PB - BENTHAM SCIENCE PUBL LTD
SN - 13816128
KW - epigenetic
KW - stem cells
KW - pluripotency
KW - cell differentiation
KW - hematopoietic development
N2 - Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.
ER -
TESAŘOVÁ, Lenka, Stanislav STEJSKAL a Irena KRONTORÁD KOUTNÁ. Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives. \textit{CURRENT PHARMACEUTICAL DESIGN}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2014, roč.~20, č.~11, s.~1674-1686. ISSN~1381-6128. Dostupné z: https://dx.doi.org/10.2174/13816128113199990524.
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